Search results for " Seconda"
showing 10 items of 975 documents
Ionic self-complementarity induces amyloid-like fibril formation in an isolated domain of a plant copper metallochaperone protein
2004
This article is available from: http://www.biomedcentral.com/1472-6807/4/7
Management of secondary hyperparathyroidism in uremic patients : the role of the new vitamin D analogs
2007
Secondary hyperparathyroidism - a common comorbid condition in patients with chronic renal insufficiency - is considered a consequence of critical determinants such as hypocalcemia, phosphate retention and reduced levels of calcitriol production. In this complex mechanism, the skeletal apparatus and the nonskeletal targets such as vascular and heart valves are often involved, thus explaining the increased risk of cardiovascular morbidity and mortality of uremic patients. In this review we will focus on the major role played by Calcitriol deficiency as a trigger of secondary hyperparathyroidism and the crucial need for obiquitous vitamin D receptor activation in order to have an optimal PTH …
Seasonal variation in total phenolic content of Dictyopteris polypodioides (Dictyotaceae) and Cystoseira amentacea (Sargassaceae) from the Sicilian c…
2014
This study focuses on the differences in total phenolic content and its seasonal variations in two temperate brown algae, Cystoseira amentacea (C. Agardh) Bory and Dictyopteris polypodioides (A.P. De Candolle) J.V. Lamouroux, inhabiting respectively the infralittoral fringe and the upper infralittoral zone. Phenolic compounds are secondary metabolites, found in almost all brown algal orders, that function as defense against grazers, epiphytes and UV radiation. Total phenolic content was determined colorimetrically with the Folin-Ciocalteu reagent. Results showed significant differences in total phenol content between D. polypodioides and C. amentacea with higher values observed in the first…
Bone marrow biopsy findings in brucellosis patients with hematologic abnormalities: useful remarks.
2013
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Protein-prime/modified vaccinia virus Ankara vector-boost vaccination overcomes tolerance in high-antigenemic HBV-transgenic mice
2015
Abstract Background Therapeutic vaccination is a novel treatment approach for chronic hepatitis B, but only had limited success so far. We hypothesized that optimized vaccination schemes have increased immunogenicity, and aimed at increasing therapeutic hepatitis B vaccine efficacy. Methods Modified Vaccinia virus Ankara (MVA) expressing hepatitis B virus (HBV) antigens was used to boost protein-prime vaccinations in wildtype and HBV-transgenic (HBVtg) mice. Results Protein-prime/MVA-boost vaccination was able to overcome HBV-specific tolerance in HBVtg mice with low and medium but not with high antigenemia. HBV-specific antibody titers, CD8+ T-cell frequencies and polyfunctionality inverse…
Comparative analysis of variation and selection in the HCV genome
2016
AbstractGenotype 1 of the hepatitis C virus (HCV) is the most prevalent of the variants of this virus. Its two main subtypes, HCV-1a and HCV-1b, are associated to differences in epidemic features and risk groups, despite sharing similar features in most biological properties. We have analyzed the impact of positive selection on the evolution of these variants using complete genome coding regions, and compared the levels of genetic variability and the distribution of positively selected sites. We have also compared the distributions of positively selected and conserved sites considering different factors such as RNA secondary structure, the presence of different epitopes (antibody, CD4 and C…
Mage-3 and influenza-matrix peptide-specific cytotoxic T cells are inducible in terminal stage HLA-A2.1+ melanoma patients by mature monocyte-derived…
2000
Abstract Dendritic cell (DC) vaccination, albeit still in an early stage, is a promising strategy to induce immunity to cancer. We explored whether DC can expand Ag-specific CD8+ T cells even in far-advanced stage IV melanoma patients. We found that three to five biweekly vaccinations of mature, monocyte-derived DC (three vaccinations of 6 × 106 s.c. followed by two i.v. ones of 6 and 12 × 106, respectively) pulsed with Mage-3A2.1 tumor and influenza matrix A2.1-positive control peptides as well as the recall Ag tetanus toxoid (in three of eight patients) generated in all eight patients Ag-specific effector CD8+ T cells that were detectable in blood directly ex vivo. This is the first time …
Stronger proprioceptive BOLD-responses in the somatosensory cortices reflect worse sensorimotor function in adolescents with and without cerebral pal…
2020
Graphical abstract
Educare alla sostenibilità. Percezioni e rappresentazioni del cambiamento climatico nella scuola secondaria di II grado: i casi di Palermo e Catanzar…
2021
Questo contributo propone uno studio sulle modalità di percezione del cambiamento climatico da parte dei giovani di età compresa tra i 16 e i 20 anni che vivono nei capoluoghi di due città del Sud Italia, Palermo, capoluogo della Sicilia e Catanzaro, capoluogo della Calabria. Attraverso interviste etnografiche, basate sull’utilizzo di un questionario aperto e sull’osservazione partecipante condotta in due scuole secondarie di secondo grado (una per ogni regione succitata), si è cercato di ricostruire il grado di consapevolezza degli studenti intervistati rispetto al cambiamento climatico in atto, chiedendo loro di indicare quali siano le forme di conoscenza implicate, le possibili cause del…