Search results for " Senso"

showing 10 items of 1766 documents

Assessing audiological, pathophysiological and psychological variables in tinnitus patients with or without hearing loss

2010

The aim of this work is to study the characteristics of tinnitus both in normal hearing subjects and in patients with hearing loss. The study considered tinnitus sufferers, ranging from 21 to 83 years of age, who were referred to the Audiology Section of Palermo University in the years 2006–2008. The following parameters were considered: age, sex, hearing threshold, tinnitus laterality, tinnitus duration, tinnitus measurements and subjective disturbance caused by tinnitus. The sample was divided into Group1 (G1), 115 subjects with normal hearing, and Group2 (G2), 197 subjects with hearing loss. Especially for G2, there was a predominance of males compared to females (P = 0.011); the highest…

AdultMalemedicine.medical_specialtyHearing lossHearing Loss SensorineuralAudiologyIrritabilityTinnitus Normal hearing Hearing lossTinnitusAudiometryotorhinolaryngologic diseasesmedicineHumansDepression (differential diagnoses)AgedAged 80 and overAbsolute threshold of hearingmedicine.diagnostic_testbusiness.industryGeneral MedicineMiddle Agedmedicine.diseaseVestibular Evoked Myogenic PotentialsSettore MED/32 - AudiologiaSettore MED/31 - OtorinolaringoiatriaOtorhinolaryngologyAcoustic Impedance TestsItalyEvoked Potentials AuditoryAnxietySensorineural hearing lossFemalemedicine.symptomAudiometrybusinessTinnitus
researchProduct

Motor learning without doing: trial-by-trial improvement in motor performance during mental training.

2010

Although there is converging experimental and clinical evidences suggesting that mental training with motor imagery can improve motor performance, it is unclear how humans can learn movements through mental training despite the lack of sensory feedback from the body and the environment. In a first experiment, we measured the trial-by-trial decrease in durations of executed movements (physical training group) and mentally simulated movements (motor-imagery training group), by means of training on a multiple-target arm-pointing task requiring high accuracy and speed. Movement durations were significantly lower in posttest compared with pretest after both physical and motor-imagery training. …

AdultMalemedicine.medical_specialtyPhysiologyeducationSensory systemDevelopmental psychologyTask (project management)Young AdultPhysical medicine and rehabilitationMotor imageryMental practiceFeedback SensorymedicineHumansLearningMovement (music)General NeuroscienceTraining (meteorology)Biomechanical PhenomenaDuration (music)Practice PsychologicalImaginationFemalePsychologyMotor learningPsychomotor PerformanceJournal of neurophysiology
researchProduct

Analysis of thiamine transporter genes in sporadic beriberi

2014

Abstract Objective Thiamine or vitamin B 1 deficiency diminishes thiamine-dependent enzymatic activity, alters mitochondrial function, impairs oxidative metabolism, and causes selective neuronal death. We analyzed for the first time, the role of all known mutations within three specific thiamine carrier genes, SLC19 A2, SLC19 A3 , and SLC25 A19 , in a patient with atrophic beriberi, a multiorgan nutritional disease caused by thiamine deficiency. Methods A 44-year-old male alcoholic patient from Morocco developed massive bilateral leg edema, a subacute sensorimotor neuropathy, and incontinence. Despite normal vitamin B 1 serum levels, his clinical picture was rapidly reverted by high-dose in…

AdultMalemedicine.medical_specialtySLC19 A- SLC25 A19SLC19 AEndocrinology Diabetes and MetabolismGene mutationBeriberimedicine.disease_causeMitochondrial Membrane Transport Proteinslaw.inventionBeriberilawInternal medicineGenotypemedicineThiamine transporterObjective: Thiamine or vitamin B1 deficiency diminishes thiamine-dependent enzymatic activity alters mitochondrial function impairs oxidative metabolism and causes selective neuronal death. We analyzed for the first time the role of all known mutations within three specific thiamine carrier genes SLC19 A2 SLC19 A3 and SLC25 A19 in a patient with atrophic beriberi a multiorgan nutritional disease caused by thiamine deficiency. Methods: A 44-year-old male alcoholic patient from Morocco developed massive bilateral leg edema a subacute sensorimotor neuropathy and incontinence. Despite normal vitamin B1 serum levels his clinical picture was rapidly reverted by high-dose intramuscular thiamine treatment suggesting a possible genetic resistance. We used polymerase chain reaction followed by amplicon sequencing to study all the known thiamine-related gene mutations identified within the Human Gene Mutation Database. Results: Thirty-seven mutations were tested: 29 in SLC19 A2 6 in SLC19 A3 and 2 in SLC25 A19. Mutational analyses showed a wild-type genotype for all sequences investigated. Conclusion: This is the first genetic study in beriberi disease. We did not detect any known mutation in any of the three genes in a sporadic dry beriberi patient. We cannot exclude a role for other known or unknown mutations in the same genes or in other thiamine-associated genes in the occurrence of this nutritional neuropathy.HumansThiamineGenePolymerase chain reactionGeneticsMutationNutrition and DieteticsbiologyMembrane Transport ProteinsThiamine Deficiencymedicine.diseaseAlcoholismEndocrinologyMutationbiology.proteinThiamineMutations
researchProduct

First experiences with a high-resolution ultrasonic scanner in the diagnosis of malignant melanomas

1983

The use of high-resolution ultrasonic instruments with transducer frequencies above 8 MHz makes it possible to visualize malignant melanomas of a thickness of more than 0.7 mm. While the sonolucent structure has not permitted the dignity of a lesion to be judged to date, it is easy to determine the maximal tumor thickness as well as infiltration of the subcutis. Thus "low-risk" and "high-risk" melanomas may be differentiated preoperatively according to these parameters. The results are of great use for the operator to plan the extent of his intervention, as well as to select patients for prophylactic regional lymphonodectomy.

AdultMalemedicine.medical_specialtyScannerSkin Neoplasmsbusiness.industryUltrasoundDermatologyGeneral MedicineMiddle AgedSurgerymedicineHumansFemaleUltrasonicsUltrasonic sensorRadiologybusinessMelanomaAgedUltrasonographyArchives of Dermatological Research
researchProduct

DPOAE‐Grams in Patients with Acute Tonal Tinnitus

2005

To investigate cochlear outer hair cell function in patients with acute tonal tinnitus and normal or near-normal hearing threshold.Prospective controlled study in an academic tertiary health center. Distortion products of otoacoustic emissions (DPOAE)-grams of 32 ears with acute tonal tinnitus and normal hearing or minimal hearing loss were compared with those of 17 healthy nontinnitus ears.Tinnitus ears exhibited relatively increased amplitudes of DPOAE at high frequencies (4-6.3 kHz) when compared with the group of healthy ears and relatively decreased DPOAE amplitudes at middle frequencies (1650-2400 Hz). Statistically significant ( P0.01) increased mean values of DPOAE amplitudes were o…

AdultMalemedicine.medical_specialtySound SpectrographyAdolescentHearing lossHearing Loss SensorineuralLoudness PerceptionOtoacoustic Emissions SpontaneousAudiologyFunctional LateralityTinnitus03 medical and health sciences0302 clinical medicineReference Valuesotorhinolaryngologic diseasesmedicineHumansIn patientProspective StudiesPitch Perception030223 otorhinolaryngologyOuter hair cellsCochleaAgedAbsolute threshold of hearingbusiness.industryAuditory ThresholdMiddle AgedHair Cells Auditory Outermedicine.anatomical_structureAcoustic StimulationOtorhinolaryngology030220 oncology & carcinogenesisReference valuesAcute DiseaseFemaleSurgerysense organsHair cellmedicine.symptombusinessTinnitusOtolaryngology–Head and Neck Surgery
researchProduct

Single-Sided Deafness: Impact of Cochlear Implantation on Speech Perception in Complex Noise and on Auditory Localization Accuracy.

2017

Objective To assess auditory localization accuracy and speech reception threshold (SRT) in complex noise conditions in adult patients with acquired single-sided deafness, after intervention with a cochlear implant (CI) in the deaf ear. Study design Nonrandomized, open, prospective patient series. Setting Tertiary referral university hospital. Patients Eleven patients with late-onset single-sided deafness (SSD) and normal hearing in the unaffected ear, who received a CI. All patients were experienced CI users. Intervention Unilateral cochlear implantation. Main outcome measures Speech perception was tested in a complex multitalker equivalent noise field consisting of multiple sound sources. …

AdultMalemedicine.medical_specialtySpeech perceptionNon-Randomized Controlled Trials as TopicHearing lossmedicine.medical_treatmentHearing Loss SensorineuralAudiologyHearing Loss Unilateral03 medical and health sciences0302 clinical medicineCochlear implantotorhinolaryngologic diseasesMedicineHumansProspective StudiesSound Localization030223 otorhinolaryngologybusiness.industryHearing TestsMiddle AgedSpeech processingCochlear ImplantationSensory SystemsNoiseCochlear ImplantsTreatment OutcomeOtorhinolaryngologySquelchSpeech PerceptionFemaleNeurology (clinical)Loudspeakermedicine.symptombusinessNoiseBinaural recording030217 neurology & neurosurgeryOtologyneurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
researchProduct

CT-guided stereotactic biopsy aided by Doppler ultrasonic vascular monitoring

1992

The use of a 20 MHz pulsed Doppler technique during stereotactic brain tumour biopsies is described. By means of a miniaturized ultrasonic probe the tissue planned for biopsy was investigated for vessel signals. Out of 41 patients, with this technique a flow-pulse curve in front of the biopsy cannula was registered in 14 cases. In 9 cases one pulse curve was determined and in 5 cases two or more flow curves were found, indicating the presence of arterial vessels. The depth of the vessels signal could be localized and this area avoided for biopsy sampling. In a series of 41 stereotactic biopsies carried out in this way there was no intra-operative haemorrhage or postoperative haematoma.

AdultMalemedicine.medical_specialtyStereotactic biopsyAdolescentStereotaxic Techniquessymbols.namesakeBiopsymedicineHumansSampling (medicine)ChildAgedNeuroradiologymedicine.diagnostic_testBrain Neoplasmsbusiness.industryBiopsy NeedleInterventional radiologyCerebral ArteriesMiddle AgedEchoencephalographyCannulaChild PreschoolsymbolsFemaleSurgeryUltrasonic sensorNeurology (clinical)RadiologyTomography X-Ray ComputedbusinessDoppler effectBlood Flow VelocityActa Neurochirurgica
researchProduct

Sudden Sensorineural Hearing Loss: Results of intratympanic steroids as salvage treatment

2012

Objective: The aim of the present study was to verify the efficacy and the safety of intratympanic dexamethasone to treat sudden sensorineural hearing loss as salvage therapy. Materials and methods: A prospective study was conducted on patients affected by idiopathic sudden hearing loss who were treated before with some systemic therapy, but without recovery of the hearing The patients able to undergo the study, but who refused salvage treatment were considered as control group. A solution of Dexamethasone 4 mg/ml was then injected through the posterior–inferior quadrant filling completely the middle ear. The follow-up in the following 6 months included an audiogram every month. Results: Th…

AdultMalemedicine.medical_specialtyTympanic MembraneAdolescentNeurosensorial Hearing Loss Steroids treatmentHearing lossHearing Loss SensorineuralSalvage therapyInjections IntralesionalAudiologyRisk AssessmentSystemic therapyDexamethasoneYoung AdultConfidence IntervalsOdds Ratiootorhinolaryngologic diseasesmedicineHumansProspective StudiesProspective cohort studyDexamethasoneAgedSalvage TherapyAnalysis of VarianceAbsolute threshold of hearingmedicine.diagnostic_testbusiness.industryAudiogramHearing Loss SuddenMiddle AgedTreatment OutcomeSettore MED/31 - OtorinolaringoiatriaOtorhinolaryngologyCase-Control StudiesAnesthesiaAudiometry Pure-ToneFemaleAudiometrymedicine.symptombusinessFollow-Up Studiesmedicine.drugAmerican Journal of Otolaryngology
researchProduct

Treatment of sudden sensorineural hearing loss with transtympanic injection of steroids as single therapy: a randomized clinical study.

2011

The aim of this study was to verify the efficacy and the safety of transtympanic dexamethasone to treat sudden sensorineural hearing loss as first and single drug method. Considering ethical implication of performing a mininvasive procedure on middle ear, we matched such proposed treatment with systemic prednisone administration that represents the widest adopted protocol. Randomized prospective study was conducted. The inclusion criterion was a sudden sensorineural hearing loss of at least 30 dB across three contiguous frequencies over a period of 24 h. Group A received transtympanic steroid injections; Group B received oral administration of steroids. 25 patients were treated with transty…

AdultMalemedicine.medical_specialtyTympanic MembraneHearing Loss SensorineuralAdministration OralInjections IntralesionalRisk AssessmentSeverity of Illness IndexDexamethasoneDrug Administration ScheduleAudiometryOral administrationPrednisoneSeverity of illnessmedicineHumansProspective StudiesProspective cohort studyDexamethasoneAgedAnalysis of Variancemedicine.diagnostic_testDose-Response Relationship Drugbusiness.industryGeneral MedicineHearing Loss SuddenMiddle AgedSurgeryCochlea Deafness Round window Sudden sensorineural hearing loss Steroid TranstympanicTreatment OutcomeOtorhinolaryngologyOtorhinolaryngologyFemaleNeurosurgeryAudiometrybusinessmedicine.drugFollow-Up Studies
researchProduct

Intratympanic Dexamethasone/Hyaluronic Acid Mix as an Adjunct to Intravenous Steroid and Vasoactive Treatment in Patients With Severe Idiopathic Sudd…

2011

To evaluate differences in effectiveness (hearing recovery rates) between idiopathic sudden sensorineural hearing loss (ISSNHL) patients treated with intravenous therapy alone and patients treated with a combination of intravenous and intratympanic therapy.Retrospective case review.Tertiary referral hospital center.Ninety-four patients with moderate ISSNHL treated with an intravenous steroid and vasoactive regimen (duration of therapy, 9 ± 2.76 d) and 76 patients with severe ISSNHL treated with a combination regimen of intravenous and intratympanic therapy (duration of therapy, 10 ± 2.71 d) were reviewed. In the latter patients' group, a series of 3 intratympanic injections of a dexamethaso…

AdultMalemedicine.medical_specialtyTympanic MembraneHearing Loss Sensorineuralmedicine.medical_treatmentIntratympanic dexamethasoneDexamethasoneInjectionsSteroidchemistry.chemical_compoundVasoactiveInternal medicineHyaluronic acidotorhinolaryngologic diseasesmedicineHumansIn patientHyaluronic AcidGlucocorticoidsRetrospective Studiesbusiness.industryHearing Loss SuddenSensory SystemsHearing recoveryTreatment OutcomeEndocrinologyOtorhinolaryngologychemistryIntravenous therapyAnesthesiaSudden sensorineural hearing lossInjections IntravenousAudiometry Pure-ToneFemaleSteroidsNeurology (clinical)businessOtology & Neurotology
researchProduct