Search results for " Severi"

showing 10 items of 289 documents

Differential Effects of Biologics on Psoriasis-Related Vascular Inflammation and Risk of Thrombosis

2020

Programa Estatal de I+D+i Orientada a los Retos de la Sociedad from Ministerio de Ciencia, Innovación y Universidades and European Regional Development Fund (Spain) [RTI2018-094436-B-I00]; Ministerio de Sanidad y Consumo CIBERehd (Spain) [CB06/04/0071]; Generalitat Valenciana (Spain) [PROMETEO/2018/141]; Proyectos Grupos Emergentes [GV/2019/043]; and Universidad Europea (Spain) (2018/UEM32 and 2019/UEM29]. 8.551 JCR (2020) Q1, 4/69 Dermatology 1.951 SJR (2020) Q1, 54/438 Biochemistry No data IDR 2020 UEV

Vasculitis0301 basic medicinemedicine.medical_specialtyEnfermedad cardiovascularImiquimodCell CommunicationDermatologyBiochemistryMiceTrombosis03 medical and health sciences0302 clinical medicinePsoriasis Area and Severity IndexPsoriasisProductos biológicosLeukocytesmedicineAnimalsHumansPsoriasisMolecular BiologyBody surface areaBiological ProductsImiquimodTumor Necrosis Factor-alphabusiness.industryEndothelial CellsThrombosisCell BiologyDermatology Life Quality Indexmedicine.diseaseDermatologyThrombosis030104 developmental biology030220 oncology & carcinogenesisMethotrexatebusinessEnfermedad de la pielMacemedicine.drugJournal of Investigative Dermatology
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Kawasaki disease in Sicily: clinical description and markers of disease severity

2016

Background: Kawasaki disease (KD) is an acute systemic vasculitis of small and middle size arteries; 15-25 % of untreated patients and 5 % of patients treated with intravenous immunoglobulin (IVIG) develop coronary artery lesions (CAL). Many studies tried to find the most effective treatment in the management of resistant KD and to select the risk factors for CAL. Our data are assessed on children from west Sicily, characterized by a genetic heterogeneity. Methods: We studied the clinical data of 70 KD Sicilian children (36 males: 51 %; 34 females: 49 %), analysed retrospectively, including: demographic and laboratory parameters; echocardiographic findings at diagnosis, at 2, 6 and 8 weeks,…

VasculitisMaleVasculitimedicine.medical_specialtyCardiovascular Disease; Kawasaki Disease; Small Vessel Vasculitis; Vasculitis030204 cardiovascular system & hematologyMucocutaneous Lymph Node SyndromeSeverity of Illness IndexSmall Vessel Vasculitis03 medical and health sciencesSettore MED/38 - Pediatria Generale E Specialistica0302 clinical medicineDisease severity030225 pediatricshemic and lymphatic diseasesCardiovascular DiseaseMedicineEffective treatmentHumansKawasaki DiseaseSicilyCardiovascular Disease; Kawasaki Disease; Small Vessel Vasculitis; Vasculitis; Pediatrics Perinatology and Child HealthRetrospective Studiesbiologybusiness.industryGenetic heterogeneityResearchmedicine.diseaseDermatologySmall Vessel Vasculitimedicine.anatomical_structureEchocardiographyChild PreschoolPediatrics Perinatology and Child HealthImmunologybiology.proteinKawasaki diseaseFemaleAntibodybusinessVasculitisBiomarkersSystemic vasculitisArteryItalian Journal of Pediatrics
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Vitamin A deficiency is associated with disease severity in patients with liver cirrhosis

2020

Vitamin A deficiencymedicine.medical_specialtyCirrhosisDisease severitybusiness.industryInternal medicinemedicineIn patientmedicine.diseasebusinessGastroenterologyZeitschrift für Gastroenterologie
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Evaluation of effect of a vitamin-based barrier cream on the clinical severity of actinic cheilitis : a preliminary study

2020

Background Actinic Cheilitis (AC) is a pathological condition of the labial mucosa considered potentially malignant. The aim of this study was to investigate the effect of treatment of AC with daily use of a vitamin-based barrier cream. Material and methods For this clinical study, 36 participants with lower-lip AC were recruited from three oral medicine services. At baseline, participants were evaluated by clinical examination and clinical severity of AC was classified as grade I to IV. All participants were dispensed a tube of a barrier cream containing vitamins A, D, E and ZnO to apply once nightly for 90 consecutive days. Monthly follow-up was performed to reclassify AC clinial severity…

Vitaminmedicine.medical_specialtymedicine.medical_treatmentBarrier creamPhysical examination030207 dermatology & venereal diseases03 medical and health scienceschemistry.chemical_compound0302 clinical medicinemedicineVitamin D and neurologyClinical severityGeneral DentistryPathologicalOral Medicine and Pathologymedicine.diagnostic_testbusiness.industryActinic cheilitisResearch030206 dentistrymedicine.disease:CIENCIAS MÉDICAS [UNESCO]DermatologychemistryUNESCO::CIENCIAS MÉDICASbusinessOral medicine
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Anti-inflammatory Function of High-Density Lipoproteins via Autophagy of IκB Kinase

2015

Background & Aims: Plasma levels of high-density lipoprotein (HDL) cholesterol are frequently found decreased in patients with inflammatory bowel disease (IBD). Therefore, and because HDL exerts anti-inflammatory activities, we investigated whether HDL and its major protein component apolipoprotein A-I (apoA-I) modulate mucosal inflammatory responses in vitro and in vivo. Methods: The human intestinal epithelial cell line T84 was used as the in vitro model for measuring the effects of HDL on the expression and secretion of tumor necrosis factor (TNF), interleukin-8 (IL-8), and intracellular adhesion molecule (ICAM). Nuclear factor-κB (NF-κB)-responsive promoter activity was studied by …

WT wild typeApolipoprotein BEMSA electrophoretic mobility shift assayMPO myeloperoxidaseIκB kinaseDSS dextran sodium sulphatemTOR the mammalian target of rapamycinRT-PCR real-time polymerase chain reactionNF-κBchemistry.chemical_compound540 ChemistryApoA-I apolipoprotein A-I10038 Institute of Clinical ChemistryOriginal ResearchTNF tumor necrosis factorbiologyIBD inflammatory bowel diseaseChemistryGastroenterologyMyeloperoxidase10076 Center for Integrative Human PhysiologyMEICS murine endoscopic index of colitis severityTumor necrosis factor alphalipids (amino acids peptides and proteins)3-MA 3-methyl adenineNF-κB nuclear factor κBHDL high-density lipoproteinLC3II light chain 3 IIPBS phosphate-buffered salinep-IKK phosphorylated IκB kinase610 Medicine & healthICAM intracellular adhesion molecule246-Trinitrobenzenesulfonic acidTg transgenicmedicineAutophagyCD Crohn’s disease2715 GastroenterologyColitislcsh:RC799-869KO knockoutHepatologyApolipoprotein A-IAutophagyInflammatory Bowel DiseaseTNBS 246-trinitrobenzenesulfonic acidmedicine.diseaseMolecular biologyIL interleukinsiRNA small interfering RNAPI-3 phosphatidylinositol-3Immunologybiology.protein2721 Hepatologylcsh:Diseases of the digestive system. GastroenterologyPFA paraformaldehydeLipoproteinDAPI 4′6-diamidino-2-phenylindoleCMGH Cellular and Molecular Gastroenterology and Hepatology
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Recommendations for uniform reporting of data following major trauma — the Utstein style

1999

Members: W.F. Dick (Co-Chairman) (Germany); P.J.F. Baskett (Co-Chairman) (UK); C.M. Grande (USA); H. Delooz (Belgium); W. Kloeck (South Africa); C. Lackner (Austria); M. Lipp (Germany); W. Mauritz (Austria); M. Nerlich (Germany); J. Nicholl (UK); J.P. Nolan (UK); P. Oakley (UK); M.J.A. Parr (UK), A. Seekamp (Belgium); E. Soreide (Norway); P.A. Steen (Norway); Luc van Camp (Belgium); B. Wolcke (Germany); D. Yates (UK).

Waiting timeUtstein Stylemedicine.medical_specialtyPediatricsbusiness.industryMajor traumaTrauma Severity IndexesMEDLINEGuidelineEmergency NursingCritical Care and Intensive Care Medicinemedicine.diseaseFamily medicineEmergency MedicinemedicineSurgeryCardiology and Cardiovascular MedicinebusinessResuscitation
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Bone marrow-derived progenitors are greatly reduced in patients with severe COPD and low-BMI.

2009

Chronic obstructive pulmonary disease (COPD) patients have reduced circulating hemopoietic progenitors. We hypothesized that severity of COPD parallels the decrease in progenitors and that the reduction in body mass index (BMI) could be associated with more severe bone marrow dysfunction. We studied 39 patients with moderate to very severe COPD (18 with low-BMI and 21 with normal-BMI) and 12 controls. Disease severity was associated to a greater reduction in circulating progenitors. Proangiogenetic and inflammatory markers correlated with disease severity parameters. Compared to normal-BMI patients, low-BMI patients showed: greater reduction in circulating progenitors; higher VEGF-A, VEGF-C…

aged; analysis of variance; antigens; blood; blood cell count; body mass index; bone marrow transplantation; case-control studies; cd; chronic obstructive; chronic obstructive pulmonary disease; colony-forming units assay; creatine kinase; cytokines; endothelial cells; enzyme-linked immunosorbent assay; fat-free mass; female; humans; intercellular signaling peptides and proteins; lactate dehydrogenases; low-bmi copd; male; metabolism; methods; middle aged; normal-bmi copd; physiology; physiopathology/surgery; pulmonary disease; severity of illness index; statistics as topicMalePathologyPhysiologyStatistics as TopicCD34GastroenterologySeverity of Illness IndexBody Mass IndexPulmonary Disease Chronic Obstructiveantigenslow-bmi copdnormal-bmi copdCreatine Kinasepulmonary diseaseBone Marrow TransplantationCOPDchronic obstructiveGeneral NeuroscienceRespiratory diseaseMiddle Agedcdfat-free massHaematopoiesismedicine.anatomical_structurephysiopathology/surgeryCytokinesIntercellular Signaling Peptides and ProteinsFemalePulmonary and Respiratory Medicinemedicine.medical_specialtyEnzyme-Linked Immunosorbent Assaymacromolecular substancesSettore MED/10 - Malattie Dell'Apparato Respiratoriochronic obstructive pulmonary diseasemethodsColony-Forming Units AssayChronic obstructive pulmonary disease low-BMI COPD normal-BMI COPD fat-free massbloodAntigens CDInternal medicineSeverity of illnessmedicineHumansProgenitor cellLactate DehydrogenasesAgedAnalysis of Variancebusiness.industryCase-control studyEndothelial Cellsmedicine.diseaseBlood Cell CountCase-Control StudiesBone marrowbusinessmetabolismRespiratory physiologyneurobiology
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Caries Severity, Decayed First Permanent Molars and Associated Factors in 6-7 Years Old Schoolchildren Living in Palermo (Southern Italy).

2023

To date, there are very few epidemiologic studies on caries disease in 6–7 year old children living in Sicily (Southern Italy). The first permanent molar (FPM) is the most commonly affected tooth in this target population, and a one-unit increase in the number of decayed FPMs is predictive of caries in other teeth and in adulthood. The primary aim of this research is to estimate the prevalence of caries in 6–7 year old schoolchildren living in Palermo and, as a secondary aim, to estimate the prevalence of affected FPMs. It was designed as a cluster cross-sectional survey on 995 children from 16 schools, selected based on their geographical location, in one of the eight city districts. Carie…

caries prevalencesocio-economic conditionchildrenItalySettore MED/28 - Malattie Odontostomatologiche610 Medicine & healthdental cariesocio-economic disparities in healthsocio-economic determinant610 Medicine & healthcaries severitySettore MED/01 - Statistica Medica
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Thyroid Stimulating Hormone Receptor Antibodies in Thyroid Eye Disease-Methodology and Clinical Applications.

2018

Background Thyroid stimulating hormone receptor antibodies (TSHR-Ab) cause autoimmune hyperthyroidism and are prevalent in patients with related thyroid eye disease (TED). Purpose To provide a historical perspective on TSHR-Ab and to present evidence-based recommendations for clinical contemporary use. Methods The authors review the recent literature pertaining to TSHR-Ab in patients with TED and describe the various immunoassays currently used for detecting TSHR-Ab and their clinical applications. Results We provide a historical summary and description of the various methods used to detect TSHR-Ab, foremost, the functional TSHR-Ab. Increasing experimental and clinical data demonstrate the …

endocrine systemendocrine system diseasesEye disease030209 endocrinology & metabolismAutoimmunitymedicine.disease_causeBioinformaticsAutoimmunity03 medical and health sciences0302 clinical medicineMedicineAnimalsHumansClinical severityReceptorAutoantibodiesbiologybusiness.industryThyroidReceptors ThyrotropinGeneral Medicinemedicine.diseaseClinical diseaseeye diseasesThyroid stimulating hormone receptorGraves OphthalmopathyOphthalmologymedicine.anatomical_structure030220 oncology & carcinogenesisbiology.proteinSurgeryAntibodybusinesshormones hormone substitutes and hormone antagonistsOphthalmic plastic and reconstructive surgery
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Interés de los índices clínicos en el tratamiento quirúrgico de la enterocolitis necrotizante

2015

INTRODUCCIÓN: Uno de los retos fundamentales de la terapia quirúrgica de los neonatos con enterocolitis necrotizante es decidir el momento adecuado para la intervención. Los índices clínicos pueden mejorar el proceso de toma de decisiones en beneficio del paciente: el MDAS (Metabolic Derangement Acuity Score) y el SNAPPE-II (Score for Neonatal Acute Physiology Perinatal Extension-II) son dos índices clínicos que fueron propuestos como buenas pruebas para decir qué pacientes con enterocolitis necrotizante necesitaban tratamiento quirúrgico; no obstante, su rendimiento diagnóstico como predictores de dicho tratamiento quirúrgico no fue calculado. El objetivo de esta investigación fue obtener …

enterocolitis necrotizanteUNESCO::CIENCIAS MÉDICAS ::Ciencias clínicas::Pediatríacurva ROC:CIENCIAS MÉDICAS ::Ciencias clínicas::Pediatría [UNESCO]índice de severidad de la enfermedad:CIENCIAS MÉDICAS ::Cirugía [UNESCO]cirugíaneonatologíaUNESCO::CIENCIAS MÉDICAS ::Cirugía
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