Search results for " Simulation"
showing 10 items of 4034 documents
Scrutiny of annexin A1 mediated membrane-membrane interaction by means of a thickness shear mode resonator and computer simulations.
2004
The dissipational quartz crystal microbalance (D-QCM) technology was applied to monitor the adsorption of vesicles to membrane-bound annexin A1 by simultaneously reading out the shifts in resonance frequency and dissipation. Solid-supported membranes (SSMs) composed of a chemisorbed octanethiol monolayer and a physisorbed 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine/1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoserine monolayer were immobilized on the gold electrode of a 5 MHz quartz plate. Adsorption and desorption of annexin A1 to the SSM was followed by means of the QCM technique. After nonbound annexin A1 was removed from solution, the second membrane binding was monitored by the D-QCM t…
Partially Reversible Adsorption of Annexin A1 on POPC/POPS Bilayers Investigated by QCM Measurements, SFM, and DMC Simulations
2005
The kinetics of annexin A1 binding to solid-supported lipid bilayers consisting of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC)/1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoserine (POPS; 4:1) has been investigated as a function of the calcium ion concentration in the bulk phase. Quartz crystal microbalance measurements in conjunction with scanning force microscopy, fluorescence microscopy, and computer simulations indicate that at a given Ca2+ concentration annexin A1 adsorbs irreversibly on membrane domains enriched in POPS. By contrast, annexin A1 adsorbs reversibly on the POPC-enriched phase, which is composed of single POPS molecules embedded within a POPC matrix. The overall are…
Robust dynamical pattern formation from a multifunctional minimal genetic circuit.
2010
Abstract Background A practical problem during the analysis of natural networks is their complexity, thus the use of synthetic circuits would allow to unveil the natural mechanisms of operation. Autocatalytic gene regulatory networks play an important role in shaping the development of multicellular organisms, whereas oscillatory circuits are used to control gene expression under variable environments such as the light-dark cycle. Results We propose a new mechanism to generate developmental patterns and oscillations using a minimal number of genes. For this, we design a synthetic gene circuit with an antagonistic self-regulation to study the spatio-temporal control of protein expression. He…
Analysing the Spanish smoke-free legislation of 2006: a new method to quantify its impact using a dynamic model.
2011
Background: There are many models that study aspects of smoking habits: the influence of price, tax, relapse time, and the effects of prohibition. There are also studies examining the effects of the Spanish smoke-free law. We wanted to build a model able to separate the effect of the law from the pre-law evolution of smoking habits. Methods: Using data from the Spanish Ministry of Health and Social Policy, we developed a dynamic model of tobacco use. The model projects the evolution over time of the number of non-smokers, smokers and ex-smokers before 2006. Then, we compared the predictions of the model with data for the years after the law came into force, 2006 and 2009. Results: We show t…
Analytically solvable Hamiltonians for quantum two-level systems and their dynamics
2014
A simple systematic way of obtaining analytically solvable Hamiltonians for quantum two-level systems is presented. In this method, a time-dependent Hamiltonian and the resulting unitary evolution operator are connected through an arbitrary function of time, furnishing us with new analytically solvable cases. The method is surprisingly simple, direct, and transparent and is applicable to a wide class of two-level Hamiltonians with no involved constraint on the input function. A few examples illustrate how the method leads to simple solvable Hamiltonians and dynamics.
Variational formulations and extra boundary conditions within stress gradient elasticity theory with extensions to beam and plate models
2016
Abstract The principle of minimum total potential energy and the primary principle of virtual power for stress gradient elasticity are presented as kinematic type constructs dual of analogous static type principles from the literature (Polizzotto, 2014; Polizzotto, 2015a). The extra gradient-induced boundary conditions are formulated as “boundary congruence conditions” on the microstructure’s deformation relative to the continuum, which ultimately require that the normal derivative of the stresses must vanish at the boundary surface. Two forms of the governing PDEs for the relevant boundary-value problem are presented and their computational aspects are discussed. The Timoshenko beam and th…
Intrusion of nonwetting liquid in paper
2007
The saturation curve of a sample of paper board was measured with mercury-intrusion porosimetry, and the three-dimensional structure of its pore space was determined by x-ray tomographic imaging. Ab initio numerical simulation of intrusion on the tomographic reconstruction, based on the lattice-Boltzmann method, was in excellent agreement with the measured saturation curve. A numerical invasion-percolation simulation in the same tomographic reconstruction showed good agreement with the lattice-Boltzmann simulation. The access function of the sample, determined from the saturation curve and the pore-throat distribution determined from the tomographic reconstruction, indicated that the ink-bo…
Fractional viscoelastic beam under torsion
2017
Abstract This paper introduces a study on twisted viscoelastic beams, having considered fractional calculus to capture the viscoelastic behaviour. Further another novelty of this paper is extending a recent numerical approach, labelled line elementless method (LEM), to viscoelastic beams. The latter does not require any discretization neither in the domain nor in the boundary. Some numerical applications have been reported to demonstrate the efficiency and accuracy of the method.
LEM for twisted re-entrant angle sections
2014
In this paper an innovative numerical method named as line element-less method, LEM, for finding solution of torsion problem has been extended to all shaped sections, including sections possessing re-entrant angles at their boundary. The response solution in terms of shear stress field or Prandtl function or warping function in all domain and for any kind of domain with arbitrary contour, may be performed quickly, calculating line integrals only. The method takes full advantage of the theory of analytic complex function and is robust in the sense that returns exact solution if this exists. Numerical implementation of LEM has been developed using Mathematica software without resorting to any…
Polluting loads detection in power systems: a decision-making strategy based on nonactive power measurements
2010
In this paper a novel decision-making strategy is proposed for the detection of polluting loads in three-phase power systems. It makes use of simple indices, which are expressed as a function of some nonactive power quantities, previously proposed by the authors and derived from the approach of the IEEE Std. 1459–2000. The decision-making rules for the proposed strategy are presented and discussed, by means of some simulation tests.