Search results for " Simulation"
showing 10 items of 4034 documents
A Cost-Effective Approach to Hardware-in-the-Loop Simulation
2012
This paper presents an approach for developing cost effective hardware-in-the-loop (HIL) simulation platforms for the use in controller software test and development. The approach is aimed at the many smaller manufacturers of e.g. mobile hydraulic machinery, which often do not have very advanced testing facilities at their disposal. A case study is presented where a HIL simulation platform is developed for the controller of a truck mounted loader crane. The total expenses in hardware and software is less than 10.000$.
The Multi-period Multi-trip Container Drayage Problem with Release and Due Dates
2021
Abstract The Container Drayage Problem (CDP) aims at routing a fleet of trucks, based at a common terminal, to serve customers while minimizing the total travel distance. Each trip starts from and ends at the terminal, and handles a subset of customers. Each customer requires either that a container is picked up or delivered. We introduce a more realistic variant, i.e., the Multi-trip Multi-period CDP with Release and Due Dates (MM-CDP-RDD), in which the planning horizon is composed of several periods (days). On each day, each truck may perform more than one trip respecting the Release and Due Dates (RDD) associated with customer services, corresponding to the first and the last day on whic…
High-accuracy approximation of piecewise smooth functions using the Truncation and Encode approach
2017
Abstract In the present work, we analyze a technique designed by Geraci et al. in [1,11] named the Truncate and Encode (TE) strategy. It was presented as a non-intrusive method for steady and non-steady Partial Differential Equations (PDEs) in Uncertainty Quantification (UQ), and as a weakly intrusive method in the unsteady case. We analyze the TE algorithm applied to the approximation of functions, and in particular its performance for piecewise smooth functions. We carry out some numerical experiments, comparing the performance of the algorithm when using different linear and non-linear interpolation techniques and provide some recommendations that we find useful in order to achieve a hig…
Evaluating objective measures of impairment to trunk strength and control for cross-country sit skiing
2021
AbstractIn Paralympic cross-country sit skiing, athlete classification is performed by an expert panel, so it may be affected by subjectivity. An evidence-based classification is required, in which objective measures of impairment must be identified. The purposes of this study were: (i) to evaluate the reliability of 5 trunk strength measures and 18 trunk control measures developed for the purposes of classification; (ii) to rank the objective measures, according to the largest effects on performance. Using a new testing device, 14 elite sit-skiers performed two upright seated press tests and one simulated poling test to evaluate trunk strength. They were also subjected to unpredictable bal…
In vitro and in vivo antileishmanial and trypanocidal studies of new N-benzene- and N-naphthalenesulfonamide derivatives.
2013
We report in vivo and in vitro antileishmanial and trypanocidal activities of a new series of N-substituted benzene and naphthalenesulfonamides 1-15. Compounds 1-15 were screened in vitro against Leishmania infantum , Leishmania braziliensis , Leishmania guyanensis , Leishmania amazonensis , and Trypanosoma cruzi . Sulfonamides 6e, 10b, and 10d displayed remarkable activity and selectivity toward T. cruzi epimastigotes and amastigotes. 6e showed significant trypanocidal activity on parasitemia in a murine model of acute Chagas disease. Moreover, 6e, 8c, 9c, 12c, and 14d displayed interesting IC50 values against Leishmania spp promastigotes as well as L. amazonensis and L. infantum amastigot…
Inhibitor-Induced Dimerization of an Essential Oxidoreductase from African Trypanosomes
2018
Trypanosomal and leishmanial infections claim tens of thousands of lives each year. The metabolism of these unicellular eukaryotic parasites differs from the human host and their enzymes thus constitute promising drug targets. Tryparedoxin (Tpx) from Trypanosoma brucei is the essential oxidoreductase in the parasite's hydroperoxide-clearance cascade. In vitro and in vivo functional assays show that a small, selective inhibitor efficiently inhibits Tpx. With X-ray crystallography, SAXS, analytical SEC, SEC-MALS, MD simulations, ITC, and NMR spectroscopy, we show how covalent binding of this monofunctional inhibitor leads to Tpx dimerization. Intra- and intermolecular inhibitor-inhibitor, pro…
Theoretical study of the interaction between sodium ion and a cyclopeptidic tubular structure.
2007
DFT calculations have been carried out to describe the pathway of a sodium ion along the stacking direction of a tubular structure set up by five cyclopeptidic units, which can be considered a suitable model of a hollow tubular structure of indefinite length. A lattice of points inside the tubular structure is defined and the DFT interaction energy values with a sodium ion are obtained. The data allow predicting a zigzag path of the ion inside the hosting structure. © 2007 Wiley Periodicals, Inc. J Comput Chem, 2007
Modeling multiple taxis: Tumor invasion with phenotypic heterogeneity, haptotaxis, and unilateral interspecies repellence
2021
We provide a short review of existing models with multiple taxis performed by (at least) one species and consider a new mathematical model for tumor invasion featuring two mutually exclusive cell phenotypes (migrating and proliferating). The migrating cells perform nonlinear diffusion and two types of taxis in response to non-diffusing cues: away from proliferating cells and up the gradient of surrounding tissue. Transitions between the two cell subpopulations are influenced by subcellular (receptor binding) dynamics, thus conferring the setting a multiscale character. We prove global existence of weak solutions to a simplified model version and perform numerical simulations for the full se…
Passenger Car Equivalent for Heavy Vehicles Crossing Turbo-roundabouts
2016
Abstract Turbo-roundabouts represent an innovative scheme of modern roundabouts which provides a spiraling traffic flow and requires drivers to choose their direction before entering the intersection, since raised lane separators mark the lanes on the ring. The configuration of the turbo-roundabout makes that patterns of conflict at entries with one and two conflicting traffic streams can coexist. This paper presents research efforts aimed at measuring quantitatively the effect of heavy vehicles on operational conditions of a turbo-roundabout. The study starts from the initial belief that the greatest constraints to the vehicular trajectories imposed by the turbo-roundabout necessarily impl…
A dynamic subgrid-scale tensorial eddy viscosity model
1999
In the Navier-Stokes equations the removal of the turbulent fluctuating velocities with a frequency above a certain fixed threshold, employed in the Large Eddy Simulation (LES), causes the appearance of a turbulent stress tensor that requires a number of closure assumptions. In this paper insufficiencies are demonstrated for those closure models which are based on a scalar eddy viscosity coefficient. A new model, based on a tensorial eddy viscosity, is therefore proposed; it employs the Germano identity [1] and allows dynamical evaluation of the single required input coefficient. The tensorial expression for the eddy viscosity is deduced by removing the widely used scalar assumption of the …