Search results for " Small"

Atherogenic lipoprotein phenotype and LDL size and subclasses in women with gestational diabetes.

2008

AIMS: Women with gestational diabetes are more likely to develop Type 2 diabetes and cardiovascular disease after pregnancy; however, the exact nature of the lipid alterations present is not clear. In Mediterranean women with gestational diabetes, we measured low-density lipoprotein (LDL) size and all seven subclasses, as well as the 'atherogenic-lipoprotein phenotype'[ALP, e.g. concomitant presence of elevated triglycerides, reduced high-density lipoprotein (HDL)-cholesterol and increased small, dense LDL]. METHODS: In 27 women with gestational diabetes and 23 healthy pregnant women matched for age, weeks of gestation and body mass index, we measured plasma lipids and LDL size and subclass…

Quantitative electron microscopic observations on Paneth cells of germfree and ex-germfree Wistar rats.

1986

Ultrastructural changes of Paneth cells of germfree (Gf) rats which had been inoculated with bacteria-containing feces from conventionally-reared (SPF) rats were quantitatively examined. 12 and 24 h after inoculation, the Paneth cells showed a striking decrease in the number of secretory granules and the occurrence of large vacuoles. Phagosomes containing bacteria were not seen. After 4 days, the secretory granules reaccumulated and smooth-surfaced apical vesicles increased in number. It is discussed that the large vacuoles may be related to membrane-retrieval events following the massive extrusion of secretory granules whereas the apical vesicles appear to serve this function when exocytos…

Effect of Oral Semaglutide on Cardiovascular Parameters and Their Mechanisms in Patients with Type 2 Diabetes: Rationale and Design of the Semaglutid…

2022

Type 2 diabetes (T2D) management has reached a point where not only optimal glycaemic control is necessary, but also additional interventions with proven cardiovascular risk reduction benefit. Subcutaneous semaglutide has been shown to provide cardiovascular protection, but its use may be limited by its injection formulation. To overcome this limitation, an oral semaglutide tablet has been developed, which could potentially be of the same value as its injection counterpart, but in a much wider group of patients with T2D, thereby allowing for broader cardiovascular risk reduction in this vulnerable patient population.A total of 100 consecutive patients with T2D and a disease duration of up t…

Assessing the feasibility of cogeneration retrofit and district heating/cooling networks in small Italian islands

2017

Sustainability of energy supply strategies in small islands has been emerging as a severe issue, due to the large margins for improvement and rationalization of the most frequently adopted solutions. In most of the European islands, large amounts of heat are wasted by the operation of engine-based power plants; conversely, heat is produced by boilers (supplied by liquid fuels) or by electric equipment for a number of different uses, like domestic hot water production or space heating in winter. In this paper a techno-economic analysis is proposed to assess the feasibility of CHP-retrofit of the existing power plants and the possible utilization of the recovered heat to supply, via a distric…

Evaluating the Sustainability in Complex Agri-Food Systems: The SAEMETH Framework

2015

During the last few years, the definition of sustainability and the translation of its general principles into practical and operative tasks have come into the foreground of scientific research and political agendas throughout the world. The understanding and the evaluation of the environmental, social and economic performances of complex agricultural food systems is probably the real challenge, and the design of more sustainable alternatives has been recognized as necessary for a correct territorial management. This study’s primary goal is the proposition of an interpretive structure “Sustainable Agri-Food Evaluation Methodology” (SAEMETH), able to guide the evaluation of the sustainabilit…

A novel current-based approach for very low variation detection of resistive sensors in wheatstone bridge configuration

2014

Small world theory and the World Wide Web: linking small world properties and website centrality

2016

This qualitative paper aims to point out the incidence of small world characteristics in the World Wide Web. To this end, some theoretical implications of small world theory (SWT) are verified using information from focus groups and in-depth interviews administered to experts and users of the World Wide Web. The purpose of this study is to investigate whether it is possible to apply small world properties to online social networks while pointing out the key variables of website centrality in that context. Building on this, the paper traces possible contributions for better management of the World Wide Web in terms of the professional use of social media to facilitate information or product …

Endoscopic interventions in the small bowel using double balloon enteroscopy: feasibility and limitations.

2007

Double-balloon enteroscopy (DBE) is a new endoscopic tool that not only allows diagnostic workup of small bowel diseases, but also makes it possible to carry out therapeutic interventions. However, for a variety of reasons, endoscopic therapy appears to be more difficult to carry out deep in the small bowel than in the upper or lower gastrointestinal tract.The purpose of this study was to evaluate the acute technical success and acute complication rate of DBE.Between June 2003 and July 2006, 353 patients (152 women, 201 men; mean age 60.3 +/- 17.1 yr) with suspected or known small bowel disease underwent 635 consecutive DBE procedures. The majority of the patients were suffering from midgas…

Prospective comparison of push enteroscopy and push-and-pull enteroscopy in patients with suspected small-bowel bleeding.

2006

BACKGROUND The management of patients with suspected mid-gastrointestinal bleeding has in the past been AND AIMS: difficult, as push enteroscopy (PE) only allows limited endoscopic access for diagnosis and treatment. Recently published uncontrolled data on push-and-pull enteroscopy (PPE) using the double-balloon technique suggest that this new method has a high diagnostic yield and therapeutic efficacy. A prospective controlled study was therefore carried out to compare PPE with PE as the common nonsurgical gold standard method. METHODS: The diagnostic yield, complications, and various examination parameters were compared in 52 consecutive patients with suspected mid-gastrointestinal bleedi…

Diagnosis of chronic anaemia in gastrointestinal disorders: a guideline by the Italian Association of Hospital Gastroenterologists and Endoscopists (…

2019

Anaemia is a common pathologic condition, present in almost 5% of the adult population. Iron deficiency is the most common cause; other mechanisms can be involved, making anaemia a multi-factorial disorder in most cases. Anaemia being a frequent manifestation in the diseases of the gastrointestinal tract, patients are often referred to gastroenterologists. Furthermore, upper and lower endoscopy and enteroscopy are pivotal to the diagnostic roadmap of anaemia. In spite of its relevance in the daily clinical practice, there is a limited number of gastroenterological guidelines dedicated to the diagnosis of anaemia. For this reason, the Italian Association of Hospital Gastroenterologists and E…