Search results for " Small"
showing 10 items of 806 documents
El alcance de los sistemas contables de gestión en las Pyme: Su impacto en la eficiencia empresarial. Estudio empírico en el sector de la madera y de…
2008
La literatura demuestra, en muchas ocasiones, que el cambio en un sistema de contabilidad de gestión (SCG) no siempre genera los resultados deseados. El objetivo general de este trabajo es conocer que relación existe entre el proceso de cambio de un SCG en las PYME y el éxito del cambio. El estudio se centra especialmente en las empresas medianas, en las que el uso de un SCG está más justificado y relacionado con su rendimiento y supervivencia en el mercado. El éxito del cambio de un SCG se va a medir a través de dos indicadores. El primer indicador, el Éxito Interno, medirá la distancia (GAP) que existe entre las expectativas (qué se esperaba) de las nuevas técnicas de gestión implantadas …
Pecking Order Versus Trade-off: An Empirical Approach to the Small and Medium Enterprise Capital Structure
2003
In this paper, we explore two of the most relevant theories that explain financial policy in small and medium enterprises (SMEs): pecking order theory and trade-off theory. Panel data methodology is used to test the empirical hypotheses over a sample of 6482 Spanish SMEs during the five-year period 1994?1998. The results suggest that both theoretical approaches contribute to explain capital structure in SMEs. However, while we find evidence that SMEs attempt to achieve a target or optimum leverage (trade-off model), there is less support for the view that SMEs adjust their leverage level to their financing requirements (pecking order model). En este trabajo, exploramos dos de las teorías má…
Effects of the benzodiazepine receptor agonist midazolam and antagonist flumazenil on 5-hydroxytryptamine release from guinea-pig intestine in vitro
1990
Isolated segments of the guinea-pig small intestine and the guinea-pig stomach were vascularly perfused and the release of 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid into the portal venous effluent determined by high pressure liquid chromatography with electrochemical detection. Test substances were applied intraarterially. The benzodiazepine receptor agonist, midazolam, concentration-dependently increased (by 58%, at 1 nmol/l) and decreased (by 32%, at 100 nmol/l) the release of 5-HT from small intestine preparations. Both effects were blocked by the benzodiazepine receptor antagonist flumazenil (10 nmol/l) The stimulatory effect of midazolam was also abolished in the presen…
Mind the gap—deficits in our knowledge of aspects impacting the bioavailability of phytochemicals and their metabolites—a position paper focusing on …
2015
This is an open access article under the terms of the Creative Commons Attribution-Non-Commercial-NoDerivs Licence.-- et al.
Fructose-1,6-Bisphosphate Protects Hippocampal Rat Slices from NMDA Excitotoxicity
2019
Effects of fructose 1,6-bisphosphate (F-1,6-P2) towards N-methyl-d-aspartate NMDA excitotoxicity were evaluated in rat organotypic hippocampal brain slice cultures (OHSC) challenged for 3 h with 30 &mu
Role of 64-slices MDCT-enterography in the evaluation of patients with suspected small bowel neoplasm.
2010
Purpose Methods and Materials Results Conclusion References Personal Information
Mapping Seasonal Variability of Buildings Electricity Demand profiles in Mediterranean Small Islands
2023
In communities with a high tourist influx and warm climate, such as Mediterranean small islands, the energy demands for space cooling and domestic hot water are expected to significantly increase during summer. Considering the current energy context, for succeeding energy transition and reducing the dependency on not endogenous fossil fuels, it is paramount to increase the deployment of renewable sources of energy, especially wind and solar which, however, are aleatory and unpredictable. Hence, to reduce the high costs for energy supply in these contexts, the analysis of the variation of energy consumption is fundamental. Moreover, mapping the spatial distribution of energy profiles can be …
γ-Glutamylcysteine detoxifies reactive oxygen species by acting as glutathione peroxidase-1 cofactor
2012
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License.
RAB3GAP1 and RAB3GAP2 modulate basal and rapamycin-induced autophagy
2014
Macroautophagy is a degradative pathway that sequesters and transports cytosolic cargo in autophagosomes to lysosomes, and its deterioration affects intracellular proteostasis. Membrane dynamics accompanying autophagy are mostly elusive and depend on trafficking processes. RAB GTPase activating proteins (RABGAPs) are important factors for the coordination of cellular vesicle transport systems, and several TBC (TRE2-BUB2-CDC16) domain-containing RABGAPs are associated with autophagy. Employing C. elegans and human primary fibroblasts, we show that RAB3GAP1 and RAB3GAP2, which are components of the TBC domain-free RAB3GAP complex, influence protein aggregation and affect autophagy at basal an…
Role of Human Sec63 in Modulating the Steady-State Levels of Multi-Spanning Membrane Proteins
2012
The Sec61 translocon of the endoplasmic reticulum (ER) membrane forms an aqueous pore, allowing polypeptides to be transferred across or integrated into membranes. Protein translocation into the ER can occur co- and posttranslationally. In yeast, posttranslational translocation involves the heptameric translocase complex including its Sec62p and Sec63p subunits. The mammalian ER membrane contains orthologs of yeast Sec62p and Sec63p, but their function is poorly understood. Here, we analyzed the effects of excess and deficit Sec63 on various ER cargoes using human cell culture systems. The overexpression of Sec63 reduces the steady-state levels of viral and cellular multi-spanning membrane …