Search results for " Small"

The transcription factor IRF1 dictates the IL-21-dependent anticancer functions of TH9 cells

2014

The TH9 subset of helper T cells was initially shown to contribute to the induction of autoimmune and allergic diseases, but subsequent evidence has suggested that these cells also exert antitumor activities. However, the molecular events that account for their effector properties are elusive. Here we found that the transcription factor IRF1 enhanced the effector function of TH9 cells and dictated their anticancer properties. Under TH9-skewing conditions, interleukin 1β (IL-1β) induced phosphorylation of the transcription factor STAT1 and subsequent expression of IRF1, which bound to the promoters of Il9 and Il21 and enhanced secretion of the cytokines IL-9 and IL-21 from TH9 cells. Further…

Cellular Uptake of siRNA-Loaded Nanocarriers to Knockdown PD-L1: Strategies to Improve T-cell Functions

2020

T-cells are a type of lymphocyte (a subtype of white blood cells) that play a central role in cell-mediated immunity. Currently, adoptive T-cell immunotherapy is being developed to destroy cancer cells. In this therapy, T-cells are harvested from a patient&rsquo

Decentralized Lightweight Group Key Management for Dynamic Access Control in IoT Environments

2020

Rapid growth of Internet of Things (IoT) devices dealing with sensitive data has led to the emergence of new access control technologies in order to maintain this data safe from unauthorized use. In particular, a dynamic IoT environment, characterized by a high signaling overhead caused by subscribers' mobility, presents a significant concern to ensure secure data distribution to legitimate subscribers. Hence, for such dynamic environments, group key management (GKM) represents the fundamental mechanism for managing the dissemination of keys for access control and secure data distribution. However, existing access control schemes based on GKM and dedicated to IoT are mainly based on ce…

Multi-Functional Nanogels for Tumor Targeting and Redox-Sensitive Drug and siRNA Delivery

2016

(1) Background: A new family of nanosystems able to discern between normal and tumor cells and to release a therapeutic agent in controlled way were synthetized by e-beam irradiation. This technique permits to obtain biocompatible, sterile, carboxyl-functionalized polyvinylpyrrolidone (PVP-co-acrylic acid) nanogels (NGs); (2) Methods: Here, we performed a targeting strategy based on the recognition of over-expressed proteins on tumor cells, like the folate receptor. The selective targeting was demonstrated by co-culture studies and flow cytometry analysis, using folate conjugated NGs. Moreover, nanoparticles were conjugated to a chemotherapeutic drug or to a pro-apoptotic siRNA through a gl…

Large- and small-mammal distribution patterns and chronostratigraphic boundaries from the Late Pliocene to the Middle Pleistocene of the Italian peni…

2007

Abstract Over the last 50 years the studies on terrestrial mammals of the Italian peninsula have provided a large volume of data and a more detailed knowledge of faunal events during the Late Pliocene and Quaternary. Moreover geological, sedimentological, palynological and magnetostratigraphical investigations on the Pliocene–Pleistocene continental sedimentary basins have yielded the possibility of a detailed calibration of the faunal successions. Thus, palaeontologists have been able to reconstruct faunal sequences and to propose biochronological scales based on large and small mammals, respectively. In the present contribution an integration of the two biochronological scales is proposed…

Expression of T-cadherin in tumor cells influences invasive potential of human hepatocellular carcinoma

2006

Overexpression of T-cadherin (T-cad) transcripts occurs in approximately 50% of human hepatocellular carcinomas (HCCs). To elucidate T-cad functions in HCC, we examined T-cad protein expression in normal and tumoral human livers and hepatoma cell lines and investigated its influence on invasive potential of HCC using RNA interference silencing of T-cad expression in Mahlavu cells. Whereas T-cad expression was restricted to endothelial cells (EC) from large blood vessels in normal livers, it was up-regulated in sinusoidal EC from 8/15 invasive HCCs. Importantly, in three of them (38%) T-cad was detected in tumor cells within regions in which E-cadherin expression was absent. Among six hepato…

Neuroendocrine Neoplasms (NENs)

2021

Neuroendocrine neoplasms (NENs) represent a rare and heterogeneous group of malignancies which can develop in many different sites of our body. They originate from the cells of the diffuse neuroendocrine system. Gastroenteropancreatic NENs were classified in four categories, including NETs G1 (WD with 20% Ki-67), and NECs (PD with >20% Ki-67) in accordance with the 2019 WHO classification (IARC WHO Classification of the digestive system tumors, on 11th July 2019). Lung NENs, in accordance with the latest WHO classification, 2015 edition, are distinguished in small cell lung cancer (SCLC), large cell neuroendocrine carcinoma (LCNEC), atypical carcinoid (AC), and typical carcinoid (TC).

Antiamphiphysin-positive stiff-person syndrome associated with small cell lung cancer

2006

The paraneoplastic amphiphysin(+) stiff-person syndrome (SPS) has so far only been described in women with breast adenocarcinoma. Here, we describe the rare case of a female patient with antiamphiphysin(+) SPS due to small cell cancer of the lung.

Treatment of advanced non-small cell lung cancer: chemotherapy with or without cisplatin?

2006

Differential Gene Expression of Medullary Thyroid Carcinoma Reveals Specific Markers Associated with Genetic Conditions

2013

Maliszewska, Agnieszka et al.