6533b82ffe1ef96bd1295177

RESEARCH PRODUCT

Cellular Uptake of siRNA-Loaded Nanocarriers to Knockdown PD-L1: Strategies to Improve T-cell Functions

Mengyi LiShuai JiangVolker MailänderVolker MailänderKatharina LandfesterRaweewan ThiramanasRaweewan Thiramanas

subject

PD-L1Small interfering RNAT-LymphocytesLymphocytemedicine.medical_treatmentT cellImmunotherapy AdoptiveB7-H1 AntigenArticlemedicineHumansNanotechnologyRNA Small Interferinglcsh:QH301-705.5Gene knockdownnanocarriersChemistryT-cellsCancercellular uptakeGeneral MedicineImmunotherapymedicine.diseasemedicine.anatomical_structurelcsh:Biology (General)siRNACancer cellCancer researchNanocarriersadoptive immunotherapy

description

T-cells are a type of lymphocyte (a subtype of white blood cells) that play a central role in cell-mediated immunity. Currently, adoptive T-cell immunotherapy is being developed to destroy cancer cells. In this therapy, T-cells are harvested from a patient&rsquo

yearjournalcountryeditionlanguage
2020-09-07Cells
10.3390/cells9092043https://www.mdpi.com/2073-4409/9/9/2043