Search results for " Small"

Hierarchically Structured Titania Films Prepared by Polymer/Colloidal Templating

2010

Hierarchically structured titania films for application in hybrid solar cells are prepared by combining microsphere templating and sol-gel chemistry with an amphiphilic diblock copolymer as a structure-directing agent. The films have a functional structure on three size scales: (1) on the micrometer scale a holelike structure for reduction of light reflection, (2) on an intermediate scale macropores for surface roughening and improved infiltration of a hole transport material, and (3) on a nanometer scale a mesoporous structure for charge generation. Poly(dimethyl siloxane)-block-methyl methacrylate poly(ethylene oxide) (PDMS-b-MA(PEO)) is used as a structure-directing agent for the prepara…

Conformation of polyethylene molecules in the melt as revealed by small-angle neutron scattering

1975

PCARE and WASF3 regulate ciliary F-actin assembly that is required for the initiation of photoreceptor outer segment disk formation

2020

Significance The photoreceptor outer segments are primary cilia, modified for phototransduction by incorporation of stacked opsin-loaded membrane disks that are continuously regenerated. This process is disrupted in several types of inherited retinal dystrophy, but the driving force remained unclear. We show that C2orf71/PCARE (photoreceptor cilium actin regulator), associated with inherited retinal dystrophy subtype RP54, efficiently recruits the Arp2/3 complex activator WASF3 to the cilium. This activates an actin dynamics-driven expansion of the ciliary tip, resembling membrane evagination in lamellipodia formation. Colocalization of this actin dynamics module to the base of the outer se…

Abitare in estensione

2014

Il saggio “Abitare in estensione” costituisce un’articolata premessa ai diversi contributi presenti nel volume esito delle attività dell’Unità di ricerca della Facoltà di Architettura di Palermo del Prin 2009 dal titolo Dalla campagna urbanizzata alla “città in estensione”: le norme compositive dell’architettura del territorio dei centri minori (Coordinatore nazionale Prof. Lugi Ramazzotti, responsabile dell’UDR locale Prof. Andrea Sciascia). Dalla stesura del modello B alla pubblicazione finale del Prin trascorrono in media tre anni. Anzi, qualche mese in meno, in considerazione dei tempi sempre più brevi imposti dalle nuove norme che regolano la rendicontazione finale. Durante questo peri…

Expressing perception in parallel ways. Sentential Small Clauses in German and Romance

2021

This chapter compares Pseudo-relatives (‘PRs’), a construction found in most Romance languages, with ‘Subject-wieclauses’ (‘SWs’), a German construction in which the subject of an embedded wie-clause precedes the complementizer wie (‘how’; e.g. Ich sah Maria, wie sie sang, lit. “I saw Mary, how she sung”, i.e. ‘I saw Mary singing’). We show that both constructions mainly occur with perception verbs, and that they have a very similar syntactic behaviour; e.g., they can be coordinated with adjectival or prepositional small clauses and have anaphoric tense. Furthermore, they both have a clausal nature but can modify a DP. We thus propose to extend Casalicchio’s (2016) analysis of PRs to SWs: t…

Huntingtin mediates dendritic transport of β-actin mRNA in rat neurons

2011

Transport of mRNAs to diverse neuronal locations via RNA granules serves an important function in regulating protein synthesis within restricted sub-cellular domains. We recently detected the Huntington's disease protein huntingtin (Htt) in dendritic RNA granules; however, the functional significance of this localization is not known. Here we report that Htt and the huntingtin-associated protein 1 (HAP1) are co-localized with the microtubule motor proteins, the KIF5A kinesin and dynein, during dendritic transport of β-actin mRNA. Live cell imaging demonstrated that β-actin mRNA is associated with Htt, HAP1, and dynein intermediate chain in cultured neurons. Reduction in the levels of Htt, H…

WRN protects against topo I but not topo II inhibitors by preventing DNA break formation

2008

The Werner syndrome helicase/3′-exonuclease (WRN) is a major component of the DNA repair and replication machinery. To analyze whether WRN is involved in the repair of topoisomerase-induced DNA damage we utilized U2-OS cells, in which WRN is stably down-regulated (wrn-kd), and the corresponding wild-type cells (wrn-wt). We show that cells not expressing WRN are hypersensitive to the toxic effect of the topoisomerase I inhibitor topotecan, but not to the topoisomerase II inhibitor etoposide. This was shown by mass survival assays, colony formation and induction of apoptosis. Upon topotecan treatment WRN deficient cells showed enhanced DNA replication inhibition and S-phase arrest, whereas af…

ACKERMANS et al.

2019

One reason for the mammalian clade’s success is the evolutionary diversity of their teeth. In herbivores, this is represented by high‐crowned teeth evolved to compensate for wear caused by dietary abrasives like phytoliths and grit. Exactly how dietary abrasives wear teeth is still not understood completely. We fed four different pelleted diets of increasing abrasiveness (L: Lucerne; G: grass; GR: grass and rice husks; GRS: grass, rice husks, and sand) to four groups of a total of 28 adult goats, all with completely erupted third molars, over a six‐month period. Tooth morphology was captured by medical computed tomography scans at the beginning and end of the controlled feeding experi…

Controllo di gestione nelle PMI e consulenti esterni

2019

L'articolo considera, a partire da un'indagine di campo su un campione di professionisti, il loro ruolo, in particolare quello degli esperti contabili e dei dottori commercialisti, nella diffusione degli strumenti e delle metodiche del controllo di gestione nell'ambito delle PMI. Management control in SMEs and external consultants. The issue of management control in small and medium-sized enterprises has long been the subject of scientific debate, as well as a key point of professionals’ interest. Starting from the recognition of the role played by the latter, this paper aims to investigate the type and level of dissemination of management control tools in SMEs by adopting the perspective o…

Profil współczesnej opiekunki małych dzieci

2017

Ostatnie lata przynoszą duże zainteresowanie problematyką pozarodzinnej opieki nad małym dzieckiem. Poszukując najlepszych rozwiązań w tym zakresie nie sposób pominąć instytucji opiekunki dziecięcej, która od wielu lat na trwale wpisuje się w ów system. W publikacji podjęto temat niani, zarówno w płaszczyźnie teoretycznej, z uwzględnieniem rysu historycznego a także uregulowań prawnych, jak i badawczego - przeanalizowano 98 ofert, które w ostatnich dwóch latach pojawiły się na portalu internetowym www.niania/pl/opiekunka/opole. Ich analiza pozwoliła nakreślić profil rozwojowy współczesnej opiekunki małych dzieci jako osoby młodej, wykształconej, z pewnym doświadczeniem zawodowym, gotową wyk…