Search results for " Small"
showing 10 items of 806 documents
Demographic characterization and genetic variability of the Girgentana goat breed by the analysis of genealogical data
2004
The aim of this paper is to present an overview of the actual Sicilian Girgentana population structure by the analysis ofgenealogical data. Statistics show that in 1983 the population consisted of 30,000 Girgentana goats; ten years lateralmost 98% of the entire Girgentana population disappeared. The remaining population consists of 461 individuals (134males and 327 females), with 368 living animals. The effective population size is 380 individuals. The inbreeding rate pergeneration was equal to 0.13%. The average estimated inbreeding level within the living male population was equal to0.8% (0-15%); and the average inbreeding level within the living female population was equal to 0.7% (0-31%…
Receptor for advanced glycation end products is subjected to protein ectodomain shedding by metalloproteinases.
2008
The receptor for advanced glycation end products (RAGE) is a 55-kDa type I membrane glycoprotein of the immunoglobulin superfamily. Ligand-induced up-regulation of RAGE is involved in various pathophysiological processes, including late diabetic complications and Alzheimer disease. Application of recombinant soluble RAGE has been shown to block RAGE-mediated pathophysiological conditions. After expression of full-length RAGE in HEK cells we identified a 48-kDa soluble RAGE form (sRAGE) in the culture medium. This variant of RAGE is smaller than a 51-kDa soluble version derived from alternative splicing. The release of sRAGE can be induced by the phorbol ester PMA and the calcium ionophore c…
Extensive nuclear gyration and pervasive non-genic transcription during primordial germ cell development in zebrafish.
2020
ABSTRACT Primordial germ cells (PGCs) are the precursors of germ cells, which migrate to the genital ridge during early development. Relatively little is known about PGCs after their migration. We studied this post-migratory stage using microscopy and sequencing techniques, and found that many PGC-specific genes, including genes known to induce PGC fate in the mouse, are only activated several days after migration. At this same time point, PGC nuclei become extremely gyrated, displaying general broad opening of chromatin and high levels of intergenic transcription. This is accompanied by changes in nuage morphology, expression of large loci (PGC-expressed non-coding RNA loci, PERLs) that ar…
In vitro glucuronidation of 7-hydroxycoumarin derivatives in intestine and liver microsomes of Beagle dogs
2019
Beagle dog is a standard animal model for evaluating nonclinical pharmacokinetics of new drug candidates. Glucuronidation in intestine and liver is an important first-pass drug metabolic pathway, especially for phenolic compounds. This study evaluated the glucuronidation characteristics of several 7-hydroxycoumarin derivatives in beagle dog's intestine and liver in vitro. To this end, glucuronidation rates of 7-hydroxycoumarin (compound 1), 7-hydroxy-4-trifluoromethylcoumarin (2), 6-methoxy-7-hydroxycoumarin (3), 7-hydroxy-3-(4-tolyl)coumarin (4), 3-(4-fluorophenyl)coumarin (5), 7-hydroxy-3-(4-hydroxyphenyl)coumarin (6), 7-hydroxy-3-(4-methoxyphenyl)coumarin (7), and 7-hydroxy-3-(1H-1,2,4-t…
I vari modi del DNA di “parlare” ai viventi fra ciò che già è noto e nuove scoperte
2018
A sessant’anni da quando Francis Crick enunciò il “dogma centrale della biologia molecolare” molte scoperte e nuove frontiere si sono avvicendate sulla questione “funzionale” di un genoma, cioè di come un DNA “parla” ai viventi. Oggi è abbastanza noto come un genoma “è”, ed occuparsi solo di questa questione strutturale ormai è sicuramente molto riduttivo, almeno sicuramente per quello umano. È invece il goal standard di questi anni scoprire come e quando un genoma si esprime, come funzio-nalmente traduce il suo messaggio rendendo questo visibile nei fe-notipi dei viventi, a prescindere dalla sua sequenza primaria di basi azotate. Ne consegue che il codice genetico, ancora valido e quasi un…
Fingerprinting white marbles of archaeometric interest by means of combined SANS and USANS
2007
We have performed a series of USANS and SANS measurements on a selected group of marble samples characterized by similar chemical composition but wide range of known metamorphic conditions. With these samples we start the building up of a data base in an attempt to correlate metamorphism and mesoscopic structure of white marbles. Experimental data have been analysed in terms of a hierarchical model. The present data highlight the importance of the structure at meso scale in identifying the provenance of the marble samples. A remarkable simple relation between the model parameters and the metamorphic degree has been found. This curve might represent a master curve to allow fingerprinting of …
SURGICAL TREATMENT OF GASTROINTESTINAL STROMAL TUMOR AND IMPLICATIONS OF NEO-ADJUVANT TREATMENT
2013
Gastrointestinal stromal tumor is not frequently type of sarouma found in the digestive system, often arise in the wall of the stomach or stromal cells of the intestinal wall.
G-CLASS: geosynchronous radar for water cycle science – orbit selection and system design
2019
The mission geosynchronous – continental land atmosphere sensing system (G-CLASS) is designed to study thediurnal water cycle, using geosynchronous radar. Although the water cycle is vital to human society, processes on timescalesless than a day are very poorly observed from space. G-CLASS, using C-band geosynchronous radar, could transform this. Itsscience objectives address intense storms and high resolution weather prediction, and significant diurnal processes such assnow melt and soil moisture change, with societal impacts including agriculture, water resource management, flooding, andlandslides. Secondary objectives relate to ground motion observations for earthquake, volcano, and subs…
THE COMPLEX, YET SMALL WORLD OF GLOBAL MULTINATIONALS – INSIGHTS ON SOME APPARENT PARADOXES
2013
Globalization, as it is today, shapes a complex, networked world – that embeds all the features (both vantages and liabilities) of a complex adaptive system. Being one of the biggest networks that define this world, the system of international business – characterized by diversity, (nondeterministic) interconnectivity and uncertainty – is also characterized by the small-world syndrome. Global multinationals are the best supporting agents in order to dismantle the apparent paradox of the complex, yet small world (and others like it).
Stability and disassembly properties of human naïve Hsp60 and bacterial GroEL chaperonins.
2015
Human Hsp60 chaperonin and its bacterial homolog GroEL, in association with the corresponding co-chaperonins Hsp10 and GroES, constitute important chaperone systems promoting the proper folding of several mitochondrial proteins. Hsp60 is also currently described as a ubiquitous molecule with multiple roles both in health conditions and in several diseases. Naïve Hsp60 bearing the mitochondrial import signal has been recently demonstrated to present different oligomeric organizations with respect to GroEL, suggesting new possible physiological functions. Here we present a combined investigation with circular dichroism and small-angle X-ray scattering of structure, self-organization, and sta…