Search results for " Software"
showing 10 items of 1178 documents
Targeting of the Leishmania Mexicana cysteine protease CPB2.8 ΔCTE by decorated fused benzo[b] thiophene scaffold.
2016
A potent and highly selective anhydride-based inhibitor of Leishmania mexicana cysteine protease CPB2.8ΔCTE (IC50 = 3.7 μM) was identified. The details of the interaction of the ligand with the enzyme active site were investigated by NMR biomimetic experiments and docking studies. Results of inhibition assays, NMR and theoretical studies indicate that the ligand acts initially as a non-covalent inhibitor and later as an irreversible covalent inhibitor by chemoselective attack of CYS 25 thiolate to an anhydride carbonyl.
Machine learning–XGBoost analysis of language networks to classify patients with epilepsy
2017
Our goal was to apply a statistical approach to allow the identification of atypical language patterns and to differentiate patients with epilepsy from healthy subjects, based on their cerebral activity, as assessed by functional MRI (fMRI). Patients with focal epilepsy show reorganization or plasticity of brain networks involved in cognitive functions, inducing ‘atypical’ (compared to ‘typical’ in healthy people) brain profiles. Moreover, some of these patients suffer from drug-resistant epilepsy, and they undergo surgery to stop seizures. The neurosurgeon should only remove the zone generating seizures and must preserve cognitive functions to avoid deficits. To preserve functions, one sho…
GPU-Based Optimisation of 3D Sensor Placement Considering Redundancy, Range and Field of View
2020
This paper presents a novel and efficient solution for the 3D sensor placement problem based on GPU programming and massive parallelisation. Compared to prior art using gradient-search and mixed-integer based approaches, the method presented in this paper returns optimal or good results in a fraction of the time compared to previous approaches. The presented method allows for redundancy, i.e. requiring selected sub-volumes to be covered by at least n sensors. The presented results are for 3D sensors which have a visible volume represented by cones, but the method can easily be extended to work with sensors having other range and field of view shapes, such as 2D cameras and lidars.
How to Write Ethical User Stories? : Impacts of the ECCOLA Method
2021
AbstractArtificial Intelligence (AI) systems are increasing in significance within software services. Unfortunately, these systems are not flawless. Their faults, failures and other systemic issues have emphasized the urgency for consideration of ethical standards and practices in AI engineering. Despite the growing number of studies in AI ethics, comparatively little attention has been placed on how ethical issues can be mitigated in software engineering (SE) practice. Currently understanding is lacking regarding the provision of useful tools that can help companies transform high-level ethical guidelines for AI ethics into the actual workflow of developers. In this paper, we explore the i…
Measuring trunk orientation with a CMOS camera: feasibility and accuracy.
2007
International audience; The purpose of this study was to develop and validate a new tool to objectively quantify trunk orientation at the bedside, especially dedicated to the measurement of the lateropulsion in acute and subacute stroke patients. We developed software to analyze 2D movement with a CMOS camera (Logitech Quickcam Pro 4000) and to calculate the orientation of a segment defined by two color markers. First, the accuracy, reproducibility and noise when measuring segment orientations were evaluated with the CMOS camera placed in different positions, and second trunk orientation was measured in static and in dynamic conditions both with a CMOS camera and with a gold standard 3D vid…
Towards a Coming Together of Transhumanism and Play
2018
We note a trend on utilizing interactive technology to extend human capacities through bodily cyborg-like integrations such as artificial limbs and implantables. This trend is often captured by the term "transhumanism", referring to the use of technology to extend human capacities. We find that many transhuman discussions appear to focus on instrumental benefits (i.e. exploiting opportunities to be more productive). We extend this by proposing engagement with transhumanism also from a perspective of "play". We reflect on our own and other's work to articulate three strategies for game designers on how they can engage with transhumanism when aiming to facilitate playful experiences. Ultimate…
A Dynamic Software Startup Competency Model
2019
Current literature suggests that engineering activities of software engineering and software startup engineering differ. Thus, there is the need to elicit competencies specific for software startup engineering. This paper proposes a model that provides the various types of competencies and their respective relevance at the various stages of software startup evolution. peerReviewed
History of Data Centre Development
2012
International audience; Computers are used to solve different problems. For solving these problems computer software and hardware are used, but for operations of those computing facilities a Data Centre is necessary. Therefore, development of the data centre is subordinated to solvable tasks and computing resources. We are studying the history of data centres’ development, taking into consideration an understanding of this. In the beginning of the computer era computers were installed in computing centres, because all computing centres have defined requirements according to whom their operation is intended for. Even though the concept of ‘data centre’ itself has been used since the 1990s, t…
Force Field for Water over Pt(111): Development, Assessment, and Comparison
2018
Metal/water interfaces are key in many natural and industrial processes, such as corrosion, atmospheric, or environmental chemistry. Even today, the only practical approach to simulate large interfaces between a metal and water is to perform force-field simulations. In this work, we propose a novel force field, GAL17, to describe the interaction of water and a Pt(111) surface. GAL17 builds on three terms: (i) a standard Lennard-Jones potential for the bonding interaction between the surface and water, (ii) a Gaussian term to improve the surface corrugation, and (iii) two terms describing the angular dependence of the interaction energy. The 12 parameters of this force field are fitted again…
High Quality Reconstruction of Dynamic Objects using 2D-3D Camera Fusion
2017
International audience; In this paper, we propose a complete pipeline for high quality reconstruction of dynamic objects using 2D-3D camera setup attached to a moving vehicle. Starting from the segmented motion trajectories of individual objects, we compute their precise motion parameters, register multiple sparse point clouds to increase the density, and develop a smooth and textured surface from the dense (but scattered) point cloud. The success of our method relies on the proposed optimization framework for accurate motion estimation between two sparse point clouds. Our formulation for fusing it closest-point and it consensus based motion estimations, respectively in the absence and pres…