Search results for " Strategy"
showing 10 items of 764 documents
Static output-feedback controller design for vehicle suspensions: an effective two-step computational approach
2014
In this study, a novel two-step methodology is applied in designing static output-feedback controllers for a class of vehicle suspension systems. Following this approach, an effective synthesis of static output-feedback controllers can be carried out by solving two consecutive linear matrix inequality optimisation problems. To illustrate the main features of the proposed design strategy, two different static output-feedback H 8 controllers are designed for a quarter-car suspension system. The first of those controllers uses the suspension deflection and the sprung mass velocity as feedback information, whereas the second one only requires the sprung mass velocity to compute the control acti…
How to develop strategies of adaptation to climate change based on a foresight exercise?
2019
Context and purpose of the study ‐ Prospective studies raise a real intellectual interest for those who contribute to them or take cognizance of it. But they are often considered too difficult to operationalize, and most of the prospective exercises are not followed by action plans, particularly at value chain level. To overcome this difficulty in linking the work of experts and the decisions of stakeholder of value chains, a particular effort was made to operationalize the outcomes from a prospective study on the French vine and wine industry in the context of climate change. The approach consisted in collecting and using the feed‐back of professionalsfrom the wine industry about these out…
Treatment Strategies for Migraine Headache
2001
Age- and Sex-Graded Data Evaluation of Vaccination Reactions after Initial Injection of the BNT162b2 mRNA Vaccine in a Local Vaccination Center in Ge…
2021
A high vaccination rate of older and particularly chronically ill people against coronavirus disease-2019 (COVID-19) is likely one of the most important factors in containing the pandemic. When Germany’s vaccination campaign started on December 2020, vaccination prioritization was initially carried out starting with older population groups. Side effect rates in 1065 individuals who had received the first dose of the messenger ribonucleic acid (mRNA) vaccine BNT162b2 Tozinameran from BioNTech/Pfizer three weeks earlier were examined retrospectively. An age- and gender-graded data analysis showed clear age and gender differences with regard to vaccine-related adverse effects. In 77% of all in…
Long-term disability trajectories in relapsing multiple sclerosis patients treated with early intensive or escalation treatment strategies
2021
Background and aims: No consensus exists on how aggressively to treat relapsing–remitting multiple sclerosis (RRMS) nor on the timing of the treatment. The objective of this study was to evaluate disability trajectories in RRMS patients treated with an early intensive treatment (EIT) or with a moderate-efficacy treatment followed by escalation to higher-efficacy disease modifying therapy (ESC). Methods: RRMS patients with ⩾5-year follow-up and ⩾3 visits after disease modifying therapy (DMT) start were selected from the Italian MS Registry. EIT group included patients who received as first DMT fingolimod, natalizumab, mitoxantrone, alemtuzumab, ocrelizumab, cladribine. ESC group patients rec…
Building a State’s Global Competitive Advantage by Improving Its Finances: A System Dynamic Model Tailored for the Italian State
2014
The present study analyzes and tests a new way to recover economy and public finances in time of crisis. An exclusive focus on State financial short-term stability risks to undermine the economic growth and to erode the social environment, thus it depletes the sources of State finances on the long-term. While a sustainable strategizing focuses on performance drivers that generate these last. Such approach in public strategizing is based on the assumption that State could increase its budgets by improving the organizational and legal framework in which private firms operate, in order to reduce their overhead costs for compliance of rules, and public facilities’ inefficiencies. This improveme…
New directions for the biopharma industry in Canada: modelling and empirical findings
2008
PurposeThe main purpose of this study is to identify features and trends shaping the business models currently prevailing in the Canadian biopharma industry, by disaggregating the business model analysis into four key areas: value creation, investment strategy, business strategy, success factorsDesign/methodology/approachResults arise from an empirical fieldwork of qualitative nature, undertaken by the end of 2004, involving deep interviews to a broad variety of key stakeholders of the biopharma industry in the Quebec region, including biopharma firms, large pharma firms, venture capital funds, research centers and recognized experts from consultancy firms and Universities.FindingsBiopharma…
Editorial: Environmental enrichment as a treatment? Epigenetic mechanisms, challenges and limitations
2021
Inhibitors of antibiotic resistance mechanisms: clinical applications and future perspectives
2020
Bacterial strains responsible for antibiotic resistant infections are increasing in an alarming way and the evolution of resistance mechanisms seems to be unstoppable. In the past decade, many efforts have been made in order to counteract this phenomenon but very few compounds have reached clinical trials. The development of new classes of antibiotics able to overcome the main bacterial drug resistance mechanisms is urgently required to counter the imminent danger of a postantibiotic era.
Consciousness and Moral Status of Animals
2021
Consciousness is the basis for granting moral status, but it is ephemeral and elusive. Both the ontological and epistemic dimension of consciousness cause hard problems for modern science and the philosophy of mind. On the one hand, consciousness is subjective, and includes conscious states with a phenomenal or qualitative character – “qualia”. It consists of mental states which are accessible to a subject only from the first-person perspective. A being is phenomenally conscious when there is something that is like to be that being. Utilitarianism uses the hedonistic strategy of the moral status, ascribing to that the demand for us to treat sentience as the fundamental property for obtainin…