Search results for " Structural"

Time-resolved X-ray scattering as a tool to probe heme proteins structural dynamics in solution

2013

Time-resolved wide-angle X-ray scattering (TR-WAXS) is a recently developed technique allowing to probe global structural changes of proteins in solution. We have used TR-WAXS to investigate large conformational changes of heme proteins (wild-type and mutant hemoglobin, neuroglobin, etc.) that cannot take place when these macromolecules are in a crystalline environment. Our data revealed detailed information on kinetic and thermodynamic properties of the investigated proteins and demonstrate the potentiality of the TR-WAXS technique.

Mode-superposition correction method for deterministic and stochastic analysis of structural systems

2001

The role played by the modal analysis in the framework of structural dynamics is fundamental from both deterministic and stochastic point of view. However the accuracy obtained by means of the classical modal analysis is not always satisfactory. Therefore it is clear the importance of methods able to correct the modal response in such a way to obtain the required accuracy. Many methods have been proposed in the last years but they are meaningful only when the forcing function is expressed by an analytical function. Moreover in stochastic analysis they fail for white noise excitation. In the paper a method able to give a very accurate response for both deterministic and stochastic input is p…

In-Depth Analysis of Pricing Problem Relaxations for the Capacitated Arc-Routing Problem

2015

Recently, Bode and Irnich [Bode C, Irnich S (2012) Cut-first branch-and-price-second for the capacitated arc-routing problem. Oper. Res. 60(5):1167–1182] presented a cut-first branch-and-price-second algorithm for solving the capacitated arc-routing problem (CARP). The fundamental difference to other approaches for exactly solving the CARP is that the entire algorithm works directly on the typically sparse underlying graph representing the street network. This enables the use of highly efficient dynamic programming-based pricing algorithms to solve the column-generation subproblem also known as the pricing problem. The contribution of this paper is the in-depth analysis of the CARP pricing…

Effective Handling of Dynamic Time Windows and Its Application to Solving the Dial-a-Ride Problem

2015

A dynamic time window relates to two operations that must be executed within a given time meaning that the difference between the points in time when the two operations are performed is bounded from above. The most prevalent context of dynamic time windows is when precedence is given for the two operations so that it is a priori specified that one operation must take place before the other. A prominent vehicle routing problem with dynamic time windows and precedence is the dial-a-ride problem (DARP), where user-specified transportation requests from origin to destination points must be serviced. The paper presents a new branch-and-cut-and-price solution approach for the DARP, the prototypi…

A perturbation approach for the response of dynamically modified structural systems

1998

The problem of the structural analysis under changes of dynamical parameters is of particular interest. This is due to the fact that often the real structures are different from the predicted ones. In this paper, an unconditionally stable step-by-step procedure, able to evaluate the deterministic response of linear structures with modifications, is presented. The proposed procedure requires the evaluation of the transition matrix, which is the fundamental operator of the step-by-step solution, by means of a perturbation approach. This technique overcomes the difficulties connected with the evaluation of the eigenproperties of the modified structures usually required to obtain the transition…

Misura delle vibrazioni sul simulacro argenteo dell'Immacolata processione

2011

DEVELOPMENT OF LATVIAN WATER MANAGEMENT SYSTEM IN THE CONTEXT OF EUROPEAN UNION CO-FUNDING

2014

Anotācija Promocijas darba mērķis ir novērtēt Latvijas ūdenssaimniecības apakšnozares attīstības priekšnosacījumus, pamatojoties uz ES fondu līdzfinansēto projektu apakšnozarē rezultātu analīzi pašvaldību griezumā. Latvijā ES fondu finansējums 2007.-2013.gadā pārsniedz 4,5 miljardus eiro, būtiski ieguldījumi ir veikti ūdenssaimniecības sistēmu sakārtošanā. Neskatoties uz to ūdenssaimniecības apakšnozare Latvijā nav plaši pētīta, kas ir skaidrojams ar to, ka, pieņemot nepieciešamību ieviest ES normatīvajos aktos paredzētos standartus attiecībā uz šo pakalpojumu sniegšanu, otrajā plānā ir palikusi nepieciešamība pārliecināties par ieguldījumu rezultātiem. Pētījuma aktualitāte ir saistīta arī …

Seismic behavior of exterior RC beam-column joints without code-specified ties in the joint core

2021

Abstract Beam-column joint design for reinforced concrete (RC) buildings is a critical issue for modern earthquake engineering, because for these structural elements, the current codes provide several geometrical constraints and reinforcement provisions, which may be very complex to implement during the construction phase. To investigate how a construction error might influence the joint behavior, two identical full-scale exterior beam-column joints specimens are built, according to Italian Building Code specifications for the high ductility class, but without the required horizontal ties inside the joint panel. This construction error could be plausible because, according to the design dra…

Slow Infection due to Lowering the Amount of Intact versus Empty Particles Is a Characteristic Feature of Coxsackievirus B5 Dictated by the Structura…

2019

Enterovirus B species typically cause a rapid cytolytic infection leading to efficient release of progeny viruses. However, they are also capable of persistent infections in tissues, which are suggested to contribute to severe chronic states such as myocardial inflammation and type 1 diabetes. In order to understand the factors contributing to differential infection strategies, we constructed a chimera by combining the capsid proteins from fast-cytolysis-causing echovirus 1 (EV1) with nonstructural proteins from coxsackievirus B5 (CVB5), which shows persistent infection in RD cells. The results showed that the chimera behaved similarly to parental EV1, leading to efficient cytolysis in both…

Mediterranean Coastal Lagoons Review: Sites to Visit before Disappearance

2022

Coastal lagoons are an established priority habitat in the European environment because of the biological communities that inhabit them. Their origin is related to the transport of sediments from a nearby river or the movement of sands by the marine currents that produce the closure of a gulf. Therefore, they are recent geological formations, which also disappear quickly if environmental conditions change. The 37 coastal lagoons with a surface area greater than 10 km2 located in the Mediterranean basin have been identified. Fishing has been the traditional use of these lagoons, in addition to their use as a navigation harbor when they are open to the sea. Pollution, quality problems and the…