Search results for " Structures"
showing 10 items of 4162 documents
Plasmalogens in the pathogenesis of glaucomatous optic neuropathy
2011
Neuronal tissues such as the retina contain high amounts of plasmalogens. One of their particularities is to concentrate polyunsaturated fatty acids (PUFA) before releasing them specifically. Several data from our laboratory suggest that plasmalogens are involved in the pathophysiology of primary open angle glaucoma (POAG), the second leading cause of blindness worldwide. The different experiments were carried out on human patients with POAG as well as on rodent models of glaucoma. They concerned either the identification of specific alterations of plasmalogen metabolism, or the efficacy of PUFAs to prevent retinal damage. The results have shown a loss of several circulating plasmalogens in…
In-mouth mechanism leading to the perception of fat and its consequence on post-prandial lipid metabolism in humans. The particular role of saliva
2014
In humans, the in-mouth perception of dietary fat in food is a complex process involving many sensory modalities (texture, aroma, taste and trigeminal). During food oral processing, a bolus is formed in which saliva is significantly incorporated thus contributing significantly to the perception of fat. In particular, it has been shown that the levels of some salivary characteristics (lipolysis, lysozyme, flux, antioxidant status, level of carbonic anhydrase and proteins) are related to the sensitivity of the individual to triolein and oleic acid. Interestingly, the involvement of some of these salivary variables in the perceived intensity and preference towards model oil emulsions was also …
Typology of exogenous organic matters based on chemical and biochemical composition to predict potential nitrogen mineralization
2010
Our aim was to develop a typology predicting potential N availability of exogenous organic matters (EOMs) in soil based on their chemical characteristics. A database of 273 EOMs was constructed including analytical data of biochemical fractionation, organic C and N, and results of N mineralization during incubation of soil–EOM mixtures in controlled conditions. Multiple factor analysis and hierarchical classification were performed to gather EOMs with similar composition and N mineralization behavior. A typology was then defined using composition criteria to predict potential N mineralization. Six classes of EOM potential N mineralization in soil were defined, from high potential N minerali…
Caspartin: thermal stability and occurrence in mollusk calcified tissues.
2005
8 pages; International audience; The fan mussel Pinna nobilis secretes a two-layered shell, the external layer of which is composed of long calcitic prisms. The dissolution of these prisms releases an assemblage of acidic intracrystalline proteins, among which caspartin, an Asp-rich protein (Marin et al., 2005). A polyclonal antibody raised against purified caspartin was used for estimating its thermal stability, and for investigating the presence of cross-reacting proteins in the shell matrices of several mollusks. In the first case, prisms of Pinna nobilis were heated at 100°C, for one to eleven days. The degradation of caspartin was followed on SDS-PAGE and on Western-blot. The experimen…
Cholesterol metabolism via cyp46a1 in glaucoma
2012
Cholesterol metabolism via cyp46a1 in glaucoma. International society for eye research (ISER) annual meeting
Implication of 24-S-hydroxycholesterol in Muller glial cell's membrane dynamics in the rat.
2016
Implication of 24-S-hydroxycholesterol in Muller glial cell's membrane dynamics in the rat.. Association-for-Research-in-Vision-and-Ophthalmology (ARVO)
Measurement of adherence to brimonidine therapy for glaucoma using electronic monitoring
2011
J. Glaucoma; Purpose: To assess the patient adherence and behavior with brimonidine twice daily (bid) or 3 times daily (tid) in patients used to topical glaucoma medication. Patients and Methods: Seventy-five patients with glaucoma or ocular hypertension were enrolled in a prospective, observational cohort study. Consenting patients were randomly assigned to brimonidine bid or tid and received conventional brimonidine eye drops with attached electronic monitoring devices for 4 weeks. Patients were not explicitly informed on the compliance monitoring. Results: The study was completed by 67 patients (89%). In 65 patients (97%), at least 1 dosing interval exceeded 24 hours. The mean adherence …
Retinal enrichment in omega-3 polyunsaturated fatty acids limits choroidal neovascularization
2016
International audience; Purpose: Age-related Macular Degeneration (AMD) is the primary cause of blindness in elderly population of western countries. Prospective epidemiologic studies have reported that omega-3 polyunsaturated fatty acids (PUFAs) reduce the risk of progression to advanced AMD, and particularly to the neovascular forms. In this study, we have investigated the beneficial effects of omega-3 PUFA on choroidal neovascularization (CNV) in mice.Methods: Fat-1 mice, endogenously converting omega-6 to omega-3 PUFA, and littermate controls were used at 4 months of age. CNV was induced unilaterally in eye fundus by photocoagulation using a 532-nm laser. Confocal scanning laser ophthal…
Functional and anatomical outcomes after successful macula-off retinal detachment surgery, a 12 month-follow-up
2016
This is an abstract that was submitted for the 2016 ARVO Annual Meeting, held in Seattle, Wash., May 1-5, 2016.; Purpose: To describe the changes of retinal structure and function after successful repair of macula-off rhegmatogenous retinal detachment (RRD). Methods: Prospective multicenter study including patients with successful surgery for macula-off RRD between October 2011 and April 2014. Those with pre-existing macular diseases or with surgery failures were excluded. Each patient underwent a complete ophthalmologic exam at baseline and at 1, 3, 6 and 12 months after the surgery (M1, M3, M6, M12, respectively). Function was assessed by measuring the best-corrected visual acuity (BCVA) …
Factors of good visual outcome in acute post-cataract endophthalmitis (friends group)
2009
International audience; Purpose: To analyze initial clinical factors of good visual outcome in patients with acute endophthalmitis following cataract surgery. Methods: A prospective study was performed in 4 University hospital (Dijon, Grenoble, Lyon, Saint-Etienne, FRIENDS group) on 100 patients with acute post-cataract endophthalmitis. Factors related to cataract surgery (complications), the initial presentation and the microbiological identification were analyzed according to the final visual outcome using univariate and multivariate analysis (SPSS 12.0). Results: 46% out of the patients had a final visual acuity less than or equal to 0.3 logMar (good visual outcome) at 6 months while 10%…