Search results for " T-cell lymphoma"

showing 10 items of 25 documents

Whole‐body magnetic resonance imaging (WB‐MRI) in lymphoma: State of the art

2019

The improvements in magnetic resonance imaging (MRI) technology and the concern related to the increased cancer risk in patients with lymphoma, also due to radiation exposure associated with imaging examinations, have led to the introduction of whole-body MRI (WB-MRI) as a radiation-free alternative to standard imaging procedures. WB-MRI seems a less histology-dependent functional imaging test than 18 F-fluorodeoxyglucose-positron emission tomography/CT (18 F-FDG-PET/CT). In patients with FDG-avid lymphomas, such as diffuse large B-cell lymphoma (DLBCL) and Hodgkin lymphoma (HL), 18 F-FDG-PET/CT remains the imaging reference standard for staging, with WB-MRI potentially being a complementar…

Cancer Researchmedicine.medical_specialtyLymphomaWhole body imagingFollicular lymphoma03 medical and health sciences0302 clinical medicineimmune system diseaseshemic and lymphatic diseasesmedicineAnimalsHumansT-cell lymphomaWhole Body ImagingB-cell lymphomaAnaplastic large-cell lymphomaNeoplasm Stagingbusiness.industryHematologyGeneral Medicinemedicine.diseaseMagnetic Resonance ImagingPeripheral T-cell lymphomaOncology030220 oncology & carcinogenesisMantle cell lymphomaRadiologybusinessDiffuse large B-cell lymphoma030215 immunologyHematological Oncology
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Pathogenetic and diagnostic significance of microRNA deregulation in peripheral T-cell lymphoma not otherwise specified

2014

Peripheral T-cell lymphomas not otherwise specified (PTCLs/NOS) are rare and aggressive tumours whose molecular pathogenesis and diagnosis are still challenging. The microRNA (miRNA) profile of 23 PTCLs/NOS was generated and compared with that of normal T-lymphocytes (CD4+, CD8+, naive, activated). The differentially expressed miRNA signature was compared with the gene expression profile (GEP) of the same neoplasms. The obtained gene patterns were tested in an independent cohort of PTCLs/NOS. The miRNA profile of PTCLs/NOS then was compared with that of 10 angioimmunoblastic T-cell lymphomas (AITLs), 6 anaplastic large-cell lymphomas (ALCLs)/ALK+ and 6 ALCLs/ALK - . Differentially expressed…

Female; Gene Expression Profiling; Humans; Lymphoma T-Cell Peripheral; Male; MicroRNAs; Oligonucleotide Array Sequence Analysis; RNA Neoplasm; Gene Expression Regulation Neoplastic; Oncology; Hematology; Medicine (all)Malemedicine.medical_specialtyPathologyPeripheral T-cell lymphoma not otherwise specifiedBiologyhemic and lymphatic diseasesInternal medicinemicroRNAmedicineHumansRNA NeoplasmOligonucleotide Array Sequence AnalysisRegulation of gene expressionHematologymicroRNA; PTCLs/NOS; GEPOligonucleotide Array Sequence AnalysiGene Expression ProfilingMedicine (all)Not Otherwise SpecifiedLymphoma T-Cell PeripheralMicroRNAHematologymedicine.diseaseGEPLymphomaGene expression profilingGene Expression Regulation NeoplasticMicroRNAsOncologyPTCLs/NOSOriginal ArticleFemaleCD8Human
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Granulomatous mycosis fungoides, a rare subtype of cutaneous T-cell lymphoma

2015

Granulomatous mycosis fungoides (GMF) is an unusual histologic subtype of cutaneous T-cell lymphoma.1 The diagnosis of GMF is usually established after observation of a granulomatous inflammatory reaction associated with a malignant lymphoid infiltrate. Epidermotropism, a clue to diagnosis in classical mycosis fungoides (MF) may be absent in about 47% of cases of GMF.2 In some instances, the granulomatous component may be intense and obscures the lymphomatous component of the infiltrate.1 There are no distinctive clinical patterns associated with GMF.1, 3

GMF granulomatous mycosis fungoidesPathologymedicine.medical_specialtyMycosis fungoidesgranulomatous mycosis fungoidesbusiness.industryCutaneous T-cell lymphomaT-Cell Receptor Gamma GeneCase ReportDermatologyGranulomatous mycosis fungoidesmedicine.diseaseDermatologyINF-α interferon alfaGranulomatous dermatitisTCR T-cell receptormedicineT-cell receptor gamma geneMF mycosis fungoidesGranulomatous DermatitisbusinessJAAD Case Reports
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Gamma-delta T-cell lymphomas.

2009

Peripheral T-cell lymphomas (TCLs) are uncommon neoplasms, accounting for about 12% of all lymphoid tumors worldwide. TCLs in which gammadelta T-cell receptors are expressed (gammadelta TCLs) are extremely aggressive and rare (<1% of lymphoid neoplasms). gammadelta TCLs originate from gammadelta T cells, a small subset of peripheral T cells with direct antigen recognition capability acting at the interface between innate and adaptive immunity. Two distinct gammadelta TCL entities are recognized: hepatosplenic T-cell lymphoma (HSTL) and primary cutaneous gammadelta T-cell lymphoma (PCGD-TCL). HSTL is a well-characterized extranodal lymphoma that has a disguised onset, secondary to intrasinus…

Hepatosplenic T-cell lymphomaT cellGene Rearrangement delta-Chain T-Cell Antigen Receptorchemical and pharmacologic phenomenaprimary cutaneous gamma delta T-cell lymphomaImmune systemmedicineHumansGamma delta T cellLymphoma T-Cell CutaneouClinical Trials as Topicbusiness.industryGene Rearrangement gamma-Chain T-Cell Antigen Receptorgamma delta T-cell receptorMedicine (all)Peripheral T-cell lymphomaLymphoma T-Cell PeripheralReceptors Antigen T-Cell gamma-deltaGene rearrangementmedicine.diseaseAcquired immune systemLymphomaLymphoma T-Cell Cutaneousstomatognathic diseasesmedicine.anatomical_structurehepatosplenic T-cell lymphomaOncologyImmunologyBone marrowbusinessHuman
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Growth, interleukin-2 production, and responsiveness to IL-2 in T4- positive T Lymphocyte populations from malignant cutaneous T cell lymphoma (Sezar…

1984

Abstract Functional analysis and surface phenotyping using monoclonal antibodies have revealed that malignant T lymphocyte populations in the peripheral blood of patients with Sezary's syndrome resemble the T helper cell populations from normal individuals. In this article we have studied the effects of the immunosuppressive drug cyclosporine A (CsA) on growth, interleukin-2 (IL-2) production, and the induction of IL-2 responsiveness of peripheral blood monocytes (PBMs) from five patients with Sezary's syndrome in vitro, using the lectin phytohemagglutinin (PHA) and the phorbol ester phorbol myristate acetate (PMA) as stimuli. The following results were obtained: PHA-induced cell proliferat…

Interleukin 2medicine.medical_specialtyT cellImmunologyCyclosporinsBiologyLymphocyte ActivationBiochemistryCyclosporin aInternal medicinemedicineHumansSezary SyndromePhytohemagglutininsReceptorCell growthCutaneous T-cell lymphomaT-Lymphocytes Helper-InducerCell BiologyHematologyT helper cellT lymphocytemedicine.diseasePhenotypemedicine.anatomical_structureEndocrinologyInterleukin-2Tetradecanoylphorbol Acetatemedicine.drugBlood
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A multicentre case control study on complicated coeliac disease: two different patterns of natural history, two different prognoses

2014

Background: Coeliac disease is a common enteropathy characterized by an increased mortality mainly due to its complications. The natural history of complicated coeliac disease is characterised by two different types of course: patients with a new diagnosis of coeliac disease that do not improve despite a strict gluten-free diet (type A cases) and previously diagnosed coeliac patients that initially improved on a gluten-free diet but then relapsed despite a strict diet (type B cases). Our aim was to study the prognosis and survival of A and B cases. Methods: Clinical and laboratory data from coeliac patients who later developed complications (A and B cases) and sex- and age-matched coeliac p…

MaleComplicationsSettore MED/09 - Medicina InternaLymphomaSmallGastroenterologyCoeliac diseaseEnteropathy-Associated T-Cell LymphomaIntestine SmallMedicineCeliac diseaseEnteropathyTreatment FailureINTESTINAL T-CELL LYMPHOMAGastroenterologyGLUTEN FREE DIETGeneral Medicinecomplicated coeliac disease; natural history; prognosis;IleitisMiddle AgedPrognosisEnteritisIntestineNatural historyAdult; Aged; Carcinoma; Case-Control Studies; Celiac Disease; Collagenous Sprue; Disease Progression; Enteritis; Enteropathy-Associated T-Cell Lymphoma; Female; Humans; Ileitis; Intestinal Neoplasms; Intestine Small; Jejunal Diseases; Lymphoma B-Cell; Male; Middle Aged; Prognosis; Treatment Failure; Diet Gluten-Freenatural historyGluten-free dietDisease ProgressionEnteropathy-associated T-cell lymphomaFemaleprognosiResearch ArticleCollagenous SprueAdultmedicine.medical_specialtyLymphoma B-CellGlutensSettore MED/12 - GASTROENTEROLOGIAcomplicated coeliac diseasecomplications/drug therapy/mortality Myocytes; celiac diseaseNODiet Gluten-FreeInternal medicineIntestinal NeoplasmsHumanscomplications/drug therapy/mortalitySurvival rateCELIAC DISEASE; Complications; INTESTINAL T-CELL LYMPHOMA; prognosis; GLUTEN FREE DIETAgedcomplications/drug therapy/mortality; Myocytes; celiac diseaseMyocytesbusiness.industryCarcinomaB-CellCase-control studynutritional and metabolic diseasesJejunal DiseasesHepatologymedicine.diseasedigestive system diseasesDietEATLCase-Control StudiesGluten-FreeGluten freebusinessComplicationcoeliac disease
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Survival of Mycosis Fungoides in Patients in the Southeast of England

2004

&lt;i&gt;Background:&lt;/i&gt; Mycosis fungoides (MF) is the most common skin lymphoma. The aetiology of MF remains unknown, and no therapy has to date significantly altered patient survival. &lt;i&gt;Objective:&lt;/i&gt; The present study examines trends in survival of MF patients in a well-defined population-based disease group, namely patients registered over a 40-year period at the Thames Cancer Registry, Southeast England. &lt;i&gt;Methods:&lt;/i&gt; The Thames Cancer Registry is a population-based registry, covering a population of approximately 14 million people. Data were taken from the Surveillance, Epidemiology and End Results cancer registry programme and the National Centre for …

Malemedicine.medical_specialtyPathologySkin NeoplasmsAntineoplastic Agents HormonalDermatologyCohort StudiesMycosis FungoidesSex FactorsResidence CharacteristicsEpidemiologymedicineHumansSezary SyndromeIn patientRegistriesSurvival rateAgedProportional Hazards ModelsMycosis fungoidesbusiness.industryProportional hazards modelAge FactorsMiddle AgedPrognosismedicine.diseaseDermatologyPeripheral T-cell lymphomaLymphomaSurvival RateEnglandPopulation SurveillanceEtiologyFemalebusinessFollow-Up StudiesSEER Program
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Rituximab plus chemotherapy provides no clinical benefit in a peripheral T-cell lymphoma not otherwise specified with aberrant expression of CD20 and…

2020

Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) is the most common entity of mature T-cell neoplasms. PTCL-NOS generally has an aggressive behavior and is often refractory to standard therapy. Only a few cases of PTCL with aberrant expression of B-cell antigens have been reported so far. This phenotypic aberrancy may lead to misdiagnosis as B-cell non-Hodgkin lymphomas and eventual inappropriate patient management, whereas in an accurately diagnosed PTCL, the presence of CD20 may appear as an appealing therapeutic target. In this setting, response to anti-CD20 monoclonal antibody in combination with chemotherapy has been poorly explored. We describe the case of a 59-year-old …

Oncologyperipheral t-cell lymphomamedicine.medical_specialtymedicine.medical_treatmentClinical BiochemistryPeripheral T-cell lymphoma not otherwise specifiedCase ReportSettore MED/08 - Anatomia Patologicarituximab.03 medical and health sciences0302 clinical medicinerituximabimmune system diseasesInternal medicinehemic and lymphatic diseasesMedicineb-cell antigens; cd20; cd79a; peripheral t-cell lymphoma; rituximabCD20cd79aperipheral T-cell lymphomaB-cell antigenCD20lcsh:R5-920Chemotherapybiologybusiness.industryNot Otherwise Specifiedcd20CD79amedicine.diseaseCD79APeripheral T-cell lymphomaLymphomab-cell antigens030220 oncology & carcinogenesisbiology.proteinRituximablcsh:Medicine (General)business030215 immunologymedicine.drug
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Peripheral T-cell lymphoma associated consecutively with hemophagocytic lymphohistiocytosis and hypereosinophilic syndrome

2003

:  Both hemophagocytic lymphohistiocytosis and hypereosinophilic syndrome have been associated with hematologic neoplasms and are respectively related to an overproduction of the cytokines Thelper 1 (Th1) and Th2 by tumor cells or reactive cells. To our knowledge, this is the first time a case of a peripheral T-cell lymphoma consecutively associated with both paraneoplastic conditions has been reported. Importantly, in this case when the lymphoma exclusively involved the bone marrow, severe paraneoplastic systemic damage, a CD8+ suppressor/cytotoxic phenotype and a hypereosinophilia not related to high levels of interleukin (IL)-5 was found. Interestingly, progression of the lymphoma coinci…

Pathologymedicine.medical_specialtyHemophagocytic lymphohistiocytosisbusiness.industryHypereosinophilic syndromeInterleukinHypereosinophiliaHematologyGeneral Medicinemedicine.diseasePeripheral T-cell lymphomaLymphomamedicine.anatomical_structureImmunologymedicineBone marrowmedicine.symptombusinessCD8European Journal of Haematology
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Hepatosplenic T-cell lymphoma

2001

Pathologymedicine.medical_specialtyHepatosplenic T-cell lymphomabusiness.industrymedicineHematologymedicine.diseasebusinessBritish Journal of Haematology
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