Search results for " TC"

Evaluation of the Impact of Multipath Data Dispersion for Anonymous TCP Connections

2007

Despite recent research efforts, wireless ad hoc networking technology remains especially prone to security attacks. In this work our contribution focuses on determining the optimal trade-off between traffic dispersion and TCP performance to reduce the chances of successful eavesdropping, while maintaining acceptable levels of throughput. For our experiments we propose a multipath-enhanced version of DSR, and we compare Tahoe, Reno and Sack TCP variants. Results show that multipath traffic dispersion impact on TCP throughput is bounded to a maximum of 25-35%, and that there is only a minimal dependence on the number of routes used, the number of consecutive packets sent on each route, the r…

Adaptive Low Priority Packet Marking for Better TCP Performance

2003

This paper proposes a packet marking scheme for TCP traffic. Unlike previous literature work, in our scheme the majority of TCP packets are transmitted as high priority. The role of a low priority packet appears that of a probe, whose goal is to early discover network congestion conditions. Low priority packets are marked according to an adaptive marking algorithm. Numerical results show that our scheme provides improved throughput/delay performance.

TCP Performance in Mobile Ad hoc Networks

2013

International audience; In this paper, we present a survey of TCP (Transmission Control Protocol) protocol for better performance in the MANET (Mobile Ad Hoc Network). After a short presentation of the main features of TCP, we give the most important problems from which TCP suffer in MANET. We present after that some approaches proposed in the literature in order to improve its performance. Our paper contains also a performance evaluation of TCP NewReno and TCP Vegas transport protocols under AODV and DSR routing protocols. The simulations are conducted under varying conditions of number of TCP connections, number of nodes and mobility.

Generation of CD8+T cells expressing two additional T-cell receptors (TETARs) for personalised melanoma therapy

2015

Adoptive T-cell therapy of cancer often fails due to the tumor cells' immune escape mechanisms, like antigen loss or down-regulation. To anticipate immune escape by loss of a single antigen, it would be advantageous to equip T cells with multiple specificities. To study the possible interference of 2 T-cell receptors (TCRs) in one cell, and to examine how to counteract competing effects, we generated TETARs, CD8(+) T cells expressing two additional T-cell receptors by simultaneous transient transfection with 2 TCRs using RNA electroporation. The TETARs were equipped with one TCR specific for the common melanoma antigen gp100 and one TCR recognizing a patient-specific, individual mutation of…

Cardio TC

2012

Detailed characterization of human Mycobacterium tuberculosis specific HLA-E restricted CD8+T cells

2018

HLA-E presented antigens are interesting targets for vaccination given HLA-Es’ essentially monomorphic nature. We have shown previously that Mycobacterium tuberculosis (Mtb) peptides are presented by HLA-E to CD8+effector T cells, but the precise phenotype and functional capacity of these cells remains poorly characterized. We have developed and utilized in this study a new protocol combining HLA-E tetramer with intracellular staining for cytokines, transcription factors and cytotoxic molecules to characterize these cells in depth. We confirm in this study the significantly increased ex vivo frequency of Mtb-peptide/HLA-E-TM+CD8+T cells in the circulation of patients with active tubercu…

Design and development of hyaluronan-functionalized polybenzofulvene nanoparticles as CD44 receptor mediated drug delivery system

2017

A tri-component polymer brush (TCPB), composed of a polybenzofulvene copolymer bearing low molecular weight hyaluronic acid (HA) on the surface of its cylindrical brush-like backbone and oligo-PEG fractions, was employed in the preparation of 350 nm nanostructured drug delivery systems capable of delivering the anticancer drug doxorubicin. The obtained drug delivery systems were characterized on the basis of drug loading and release, dimensions and zeta potential, morphology and in vitro cell activity, and uptake on three different human cell lines, namely the bronchial epithelial 16HBE, the breast adenocarcinoma MCF-7, and the colon cancer HCT116 cells. Finally, the ability of doxorubicin…

EMANGIOPERICITOMA INTRACRANICO PRESENTAZIONE DI UN CASO E REVISIONE DELLA LETTERATURA

2013

SCOPO DEL LAVORO Presentiamo a un caso di emangiopericitoma (HPC) in un paziente emicranico (maschio, 49 enne) che giunge alla nostra attenzione per l’insorgenza di confusione mentale e emisindrome sentitivo-motoria destra. Saranno inoltre riportati alcuni cenni sulla classificazione internazionale di questo raro tumore mesenchimale riccamente vascolarizzato, non tralasciando le possibili diagnosi differenziali con altri più comuni espansi di pertinenza extra- assiale. MATERIALI E METODI Dopo una prima valutazione in PS il paziente è stato sottoposto a esame TC encefalo e trasferito nel reparto di neurochirurgia. Successivamente ad un esame RM encefalo con sequenze morfologiche convenzion…

MALATTIA DI ERDHEIM–CHESTER: RARE LOCALIZZAZIONI SPLANCNO- ED INTRA-CRANICHE IN PAZIENTE CON STADIO AVANZATO DI MALATTIA

2015

SCOPO DEL LAVORO Presentiamo il caso di una donna di 63 anni con storia di pseudotumor orbitae e diagnosi tardiva di Malattia di Erdheim-Chester (MEC) con coinvolgimento multisistemico e rare localizzazioni a livello splancno- ed intracranico. MATERIALI E METODI La paziente, a causa della comparsa di astenia progressivamente ingravescente, vomito e disfagia per i solidi veniva condotta al PS dove eseguiva ECG ed esami ematochimici e veniva ricoverata con la diagnosi di disidratazione e squilibrio elettrolitico. L’esame obiettivo evidenziava pallore e disidratazione di cute e mucose, ipotrofia muscolare e proptosi bulbare bilaterale da pseudotumor orbitario infiammatorio cronico con evidenti…

Granice zewnętrzne Unii Europejskiej a bezpieczeństwo narodowe państw członkowskich w kontekście współczesnego kryzysu migracyjnego

2016

Unia Europejska jest miejscem, w którym swoboda obywateli wyrażona jest poprzez możliwość przemieszania się, podróżowania, pracy,nauki lub życia w wybranym kraju UE. Realizacja tej wolności była wynikiem zniesienia kontroli na granicach wewnętrznych Unii. Jednak dla członka UE ceną tej wolności jest konieczność zapewnienia bezpieczeństwa narodowego, co sprawia, że ochronę granic zewnętrznych postrzega się jako specjalne zadanie. Unia Europejska, za pośrednictwem układu z Schengen, tworzy instytucje w zakresie ochrony granic zewnętrznych, w zakresie zapewnienia bezpieczeństwa narodowego państw członkowskich. Obecny kryzys migracyjny jest weryfikacją skuteczności tych instytucji.