Search results for " TESTI"
showing 10 items of 1926 documents
The COVID-19 outbreak and rheumatologic skin diseases.
2020
Comparison of Reported Deaths From COVID-19 and Increase in Total Mortality in Italy
2020
This analysis compares reported deaths from COVID-19, February 23 to April 4, 2020, and total mortality in Italy from January 12 through April 4 in the years 2015 through 2020.
An inhaled tumor necrosis factor-alpha-derived TIP peptide improves the pulmonary function in experimental lung injury: inhaled TIP peptide in experi…
2012
INTRODUCTION The lectin-like domain of TNF-α enhances the fluid clearance across the alveolar barrier. For experimental purposes, the lectin-like domain can be mimicked by a synthetic peptide representing the TIP-motif of TNF-α. The present study aims to assess the acute effect of TIP on the pulmonary function in a porcine model of acute respiratory distress syndrome (ARDS). METHODS Lung injury was induced in 16 pigs (25-27 kg) by bronchoalveolar lavage followed by injurious ventilation. Following randomisation, either nebulised TIP (1 mg/kg; AP301, APEPTICO, Vienna, Austria) or water for injection (control group) was administered. During 5 h of monitoring, the extravascular lung water inde…
Random allogeneic blood transfusion in pigs: characterisation of a novel experimental model.
2019
BackgroundOrgan cross-talk describes interactions between a primary affected organ and a secondarily injured remote organ, particularly in lung-brain interactions. A common theory is the systemic distribution of inflammatory mediators that are released by the affected organ and transferred through the bloodstream. The present study characterises the baseline immunogenic effects of a novel experimental model of random allogeneic blood transfusion in pigs designed to analyse the role of the bloodstream in organ cross-talk.MethodsAfter approval of the State and Institutional Animal Care Committee, 20 anesthetized pig were randomized in a donor and an acceptor (eachn = 8): the acceptor animals …
Improving Dissolution Behavior and Oral Absorption of Drugs with pH-Dependent Solubility Using pH Modifiers: A Physiologically Realistic Mass Transpo…
2021
Orally dosed drugs must dissolve in the gastrointestinal (GI) tract before being absorbed through the epithelial cell membrane. In vivo drug dissolution depends on the GI tract's physiological conditions such as pH, residence time, luminal buffers, intestinal motility, and transit and drug properties under fed and fasting conditions (Paixao, P. et al. Mol. Pharm. 2018 and Bermejo, et al. M. Mol. Pharm. 2018). The dissolution of an ionizable drug may benefit from manipulating in vivo variables such as the environmental pH using pH-modifying agents incorporated into the dosage form. A successful example is the use of such agents for dissolution enhancement of BCS class IIb (high-permeability,…
Viscosity-mediated negative food effect on oral absorption of poorly-permeable drugs with an absorption window in the proximal intestine: In vitro ex…
2014
Concomitant food intake can diminish oral absorption of drugs with limited permeability and an absorption window in the proximal intestine, due to viscosity-mediated decrease in dosage form disintegration time and drug dissolution rate. Three poorly-permeable drugs (atenolol, metformin hydrochloride, and furosemide) exhibiting negative food effect, and one highly-soluble and highly-permeable (metoprolol tartrate), serving as a negative control, were selected for the study. In vitro and in silico tools were used to evaluate the influence of media viscosity on drug bioperformance under fasted and fed conditions. The obtained results demonstrated that increased medium viscosity in the presence…
Feasibility of using more polishable aggregates in dense-graded asphalt surface mixture: Case study of dolomite
2022
This study aimed to evaluate the feasibility of using more dolomite aggregates in asphalt surface mixtures that are typically used by West Virginia Division of Highways (WVDOH). The laboratory test results indicated that increasing dolomite content in asphalt surface mixtures resulted in a faster deterioration rate at the early polishing stage. In addition, asphalt surface mixtures containing more than 50% dolomite coarse aggregates would significantly reduce roadway safety. The field test results validated that dolomite shall not exceed 50% of coarse aggregate in asphalt surface mixture if the projected traffic volume is greater than 3.0 million equivalent single axle loads (ESALs).
From Laboratory Mixes Evaluation to Full Scale Test: Fatigue Behavior of Bio-Materials Recycled Asphalt Mixtures
2020
The present paper describes the full-scale accelerated test, carried out on asphalt pavements made up with bio-materials, especially designed to help reusing Reclaimed Asphalt (RA) by re-activating the aged binder. Four pavement sections were evaluated: three pavement sections with innovative bio-materials (bio-recycled asphalt mixtures), and a reference section with a conventional, high modulus asphalt mix (EME2). In this study, fatigue resistance was first evaluated in laboratory, with two-points bending test, and then at full scale under heavy traffic loading, with the IFSTTAR accelerated pavement testing facility. The evolution of bio-materials recycled asphalt mixture characteristics, …
A Digital Twin for Lift Planning With Offshore Heave Compensated Cranes
2020
Abstract This paper presents a state-of-the-art digital twin of a hydraulic actuated winch that is used for heave compensation in offshore applications. The digital twin is used as part of a larger simulation model that involves all necessary components to perform lift planning and, subsequently, determine the corresponding weather window. The winch simulation model is described and verified by means of full-scale measurements. In addition, a set of acceptance criteria are presented that should be used whenever verifying digital twins of heave compensating winches that are to be used for lift planning.
Non-destructive automatic determination of aspect ratio and cross-sectional properties of fibres
2015
A novel method for computerised estimation of the aspect ratio distribution and various cross-sectional geometrical properties of fibres in short-fibre reinforced composites is proposed. The method, based on X-ray micro-computed tomography, is non-destructive and does not require user intervention. Based on results on specially fabricated model material, the accuracy and precision of the method seems adequate. The method is applied in analysing a manufacturing process of wood fibre reinforced thermoplastic composite. The results indicate a significant decrease of the aspect ratio of fibres during the processing steps. Finally, the feasibility of the method is assessed by estimating paramete…