Search results for " TYR"
showing 10 items of 362 documents
Towards an understanding of the molecular basis of immune responses in sponges: The marine demospongeGeodia cydonium as a model
1999
The phylogenetic position of the phylum Porifera (sponges) is near the base of the kingdom Metazoa. During the last few years, not only rRNA sequences but, more importantly, cDNA/genes that code for proteins have been isolated and characterized from sponges, in particular from the marine demosponge Geodia cydonium. The analysis of the deduced amino acid sequences of these proteins allowed a molecular biological approach to the question of the monophyly of the Metazoa. Molecules of the extracellular matrix/basal lamina, with the integrin receptor, fibronectin, and galectin as prominent examples, and of cell-surface receptors (tyrosine kinase receptor), elements of sensory systems (crystallin…
Redox signaling and histone acetylation in acute pancreatitis
2011
Histone acetylation via CBP/p300 coordinates the expression of proinflammatory cytokines in the activation phase of inflammation, particularly through mitogen-activated protein kinases (MAPKs), nuclear factor-κB (NF-κB), and signal transducers and activators of transcription (STAT) pathways. In contrast, histone deacetylases (HDACs) and protein phosphatases are mainly involved in the attenuation phase of inflammation. The role of reactive oxygen species (ROS) in the inflammatory cascade is much more important than expected. Mitochondrial ROS act as signal-transducing molecules that trigger proinflammatory cytokine production via inflammasome-independent and inflammasome-dependent pathways. …
Heurs et malheurs d’un tyran: le cas de Hiéron de Syracuse, in Pallas 79, 2009, 81-103
2009
The analysis focuses on the figure of Hieron, a Syracusan tyrant who met with mixed fortune in scholarly studies. Often compared with his brother Gelon, the second of the Deinomenides was seen as a rapacious and violent tyrant. We here reconsider the testimonies on Hieron in order to find out to what extent that judgement actually corresponds to the image which the tradition of Antiquity gave of the tyrant. The case of Hieron offers above all an opportunity to examine the lines which oriented the studies on tyranny in Sicily and to provide an outline of the latest prospects of research. L’analyse se concentre sur la figure de Hiéron, tyran de Syracuse, qui eut une fortune diverse dans les é…
EGFR tyrosine kinase inhibitor therapy continuation with high-dose hypofractionated radiotherapy in EGFR-mutated non-small cell lung cancer (NSCLC) p…
2020
e21580 Background: EGFR tyrosine kinase inhibitors (TKIs) represent the standard first-line therapy for advanced non-small cell lung cancer (NSCLC) patients with activating EGFR mutations. However, despite initial marked responses, tumors invariably develop acquired resistance to TKIs. Oligoprogression is commonly observed during treatment with oncogene-directed therapies, including EGFR TKIs, and refers to patients who experience disease progression only in limited sites as a result of heterogeneous mechanisms of resistance. The use of local ablative treatments for these resistant lesions may extend the duration of TKI therapy and potentially improve long-term disease control and survival…
VIZUALINIS MOKTYTOJO ĮVAIZDIS: LYGINAMASIS TYRIMAS
2013
Dr. paed., Instituteof Educational Sciences, University of Latvia, Latvia. E-mail: iveta.kestere@lu.lv Address: Laimdotas 37, Rīga LV1006, Latvia Phone +371 29496660; +32 473 63 37 98PhD, Graduate School of Education, North West University, South Africa. E-mail: Charl.Wolhuter@nwu.ac.za Address: North-West University, Private Bag X 6001, Potchefstroom 2520, South AfricaPhD, Educational Sciences Department, Yeditepe University, Turkey. E-mail: ricardolozanov@gmail.comStraipsnyje „Vizualinis mokytojo įvaizdis: lyginamasis tyrimas“ pateikiami tyrimo, atlikto dešimtyje šalių – Anglijoje, Pietų Afrikoje, Serbijoje, Slovėnijoje, Graikijoje, Bulgarijoje, Latvijoje, Turkijoje, Pakistane ir Meksi…
AML-associated Flt3 kinase domain mutations show signal transduction differences compared with Flt3 ITD mutations
2005
Activating mutations of Flt3 are found in approximately one third of patients with acute myeloid leukemia (AML) and are an attractive drug target. Two classes of Flt3 mutations occur: internal tandem duplications (ITDs) in the juxtamembrane and point mutations in the tyrosine kinase domain (TKD). We and others have shown that Flt3-ITD induced aberrant signaling including strong activation of signal transducer and activator of transcription 5 (STAT5) and repression of CCAAT/estradiol-binding protein α (c/EBPα) and Pu.1. Here, we compared the signaling properties of Flt3-ITD versus Flt3-TKD in myeloid progenitor cells. We demonstrate that Flt3-TKD mutations induced autonomous growth of 32D ce…
Clinical resistance to the kinase inhibitor PKC412 in acute myeloid leukemia by mutation of Asn-676 in the FLT3 tyrosine kinase domain.
2005
Activating mutations in the FLT3 tyrosine kinase (TK) occur in approximately 35% of patients with acute myeloid leukemia (AML). Therefore, targeting mutated FLT3 is an attractive therapeutic strategy, and early clinical trials testing FLT3 TK inhibitors (TKI) showed measurable clinical responses. Most of these responses were transient; however, in a subset of patients blast recurrence was preceded by an interval of prolonged remission. The etiology of clinical resistance to FLT3-TKI in AML is unclear but is of major significance for the development of future therapeutic strategies. We searched for mechanisms of resistance in 6 patients with AML who had relapses upon PKC412 treatment. In an …
Cross-Inhibition of Interferon-Induced Signals by GM-CSF Through a Block in Stat1 Activation
2007
We investigated the effects of granulocyte-macrophage colony-stimulating factor (GM-CSF) on biologic signals induced by interferon-alpha (IFN-alpha) and IFN-gamma. In hematopoietic cell lines, IFN-induced signaling was investigated by Western blotting, electrophoretic mobility shift assays (EMSA), flow cytometry, protein-tyrosine phosphatase (PTP) assays, and RT-PCR. GM-CSF inhibited IFN-alpha-induced and IFN-gamma-induced Stat1 tyrosine phosphorylation in a time-dependent manner. EMSA showed that GM-CSF inhibited IFN-alpha-induced and IFN-gamma-induced IFN-gamma activator sequence (GAS) binding activity. As a consequence, IFN-induced transcription of the early response gene, IFN-stimulated…
Karl Julius Beloch e la tirannide di Dionisio I in Sicilia
2018
L’articolo prende in esame le riflessioni di K.J. Beloch sulla tirannide di Dionisio I di Siracusa, tanto in uno studio specificamente dedicato, quanto nella Griechische Geschichte in cui il sovrano siceliota viene indicato quale precursore della politica di Filippo II e di Alessandro Magno. Le conclusioni sono analizzate alla luce dell’impostazione storiografica e degli interessi scientifici dello studioso tedesco e verificate sulla base della ricezione che esse ebbero presso i colleghi e nelle indagini successive sul tema. This article aims at inquiring the K.J. Beloch’s considerations about the tyranny of Dionysius I of Syracuse, in a specifically dedicated essay as well as in his major …
Not all KIT 557/558 codons mutations have the same prognostic influence on recurrence-free survival: breaking the exon 11 mutations in gastrointestin…
2021
Background: Although the gastrointestinal stromal tumor (GIST) genotype is not currently included in risk-stratification systems, a growing body of evidence shows that the pathogenic variant (PV) type and codon location hold a strong prognostic influence on recurrence-free survival (RFS). This information has particular relevance in the adjuvant setting, where an accurate prognostication could help to better identify high-risk tumors and guide clinical decision-making. Materials and Methods: Between January 2005 and December 2020, 96 patients with completely resected GISTs harboring a KIT proto-oncogene receptor tyrosine kinase ( KIT) exon 11 PV were included in the study. We analyzed the t…