Search results for " Time"
showing 10 items of 3005 documents
AN IL-6/IL-6 SOLUBLE RECEPTOR (IL-6R) HYBRID PROTEIN (H-IL-6) INDUCES EPO-INDEPENDENT ERYTHROID DIFFERENTIATION IN HUMAN CD34+CELLS
2000
H-IL-6 is a hybrid protein constructed to contain IL-6 and its soluble receptor linked by a flexible peptide chain. Here we show that H-IL-6 strongly enhances proliferation of human CD34(+)cells in serum-free liquid culture, and that the majority of the cells generated belong to the erythroid lineage, being positive for the marker Glycophorin A. Conversely, H-IL-6 does not increase the number of myeloid, CD13-positive cells. Comparable effects are observed on progenitors from cord blood and adult peripheral blood. Therefore, H-IL-6 triggers an erythroid-inducing signal in haematopoietic progenitor cells, independently from erythropoietin (EPO).
Finite-Time Control and Estimation for Complex and Practical Dynamical Systems
2014
1Merchant Marine College, Shanghai Maritime University, Shanghai 201306, China 2Department of Mechanical and Aerospace Engineering, The Ohio State University, Columbus, OH 43202, USA 3Department of Engineering, Faculty of Engineering and Science, University of Agder, 4898 Grimstad, Norway 4School of Automation, Harbin Engineering University, Harbin 150001, China 5Deep Space Exploration Research Center, School of Astronautics, Harbin Institute of Technology, Harbin 150001, China
Nanoseconds Timing System Based on IEEE 1588 FPGA Implementation
2019
Clock synchronization procedures are mandatory in most physical experiments where event fragments are readout by spatially dislocated sensors and must be glued together to reconstruct key parameters (e.g. energy, interaction vertex etc.) of the process under investigation. These distributed data readout topologies rely on an accurate time information available at the frontend, where raw data are acquired and tagged with a precise timestamp prior to data buffering and central data collecting. This makes the network complexity and latency, between frontend and backend electronics, negligible within upper bounds imposed by the frontend data buffer capability. The proposed research work describ…
CUDA-Accelerated Alignment of Subsequences in Streamed Time Series Data
2014
Euclidean Distance (ED) and Dynamic Time Warping (DTW) are cornerstones in the field of time series data mining. Many high-level algorithms like kNN-classification, clustering or anomaly detection make excessive use of these distance measures as subroutines. Furthermore, the vast growth of recorded data produced by automated monitoring systems or integrated sensors establishes the need for efficient implementations. In this paper, we introduce linear memory parallelization schemes for the alignment of a given query Q in a stream of time series data S for both ED and DTW using CUDA-enabled accelerators. The ED parallelization features a log-linear calculation scheme in contrast to the naive …
GEM
2014
The widespread use of digital sensor systems causes a tremendous demand for high-quality time series analysis tools. In this domain the majority of data mining algorithms relies on established distance measures like Dynamic Time Warping (DTW) or Euclidean distance (ED). However, the notion of similarity induced by ED and DTW may lead to unsatisfactory clusterings. In order to address this shortcoming we introduce the Gliding Elastic Match (GEM) algorithm. It determines an optimal local similarity measure of a query time series Q and a subject time series S. The measure is invariant under both local deformation on the measurement-axis and scaling in the time domain. GEM is compared to ED and…
The Large Observatory for X-ray Timing (LOFT)
2012
High-time-resolution X-ray observations of compact objects provide direct access to strong-field gravity, to the equation of state of ultra-dense matter and to black hole masses and spins. A 10 m^2-class instrument in combination with good spectral resolution is required to exploit the relevant diagnostics and answer two of the fundamental questions of the European Space Agency (ESA) Cosmic Vision Theme "Matter under extreme conditions", namely: does matter orbiting close to the event horizon follow the predictions of general relativity? What is the equation of state of matter in neutron stars? The Large Observatory For X-ray Timing (LOFT), selected by ESA as one of the four Cosmic Vision M…
Deep-Time Phylogenetic Clustering of Extinctions in an Evolutionarily Dynamic Clade (Early Jurassic Ammonites)
2012
7 pages; International audience; Conservation biologists and palaeontologists are increasingly investigating the phylogenetic distribution of extinctions and its evolutionary consequences. However, the dearth of palaeontological studies on that subject and the lack of methodological consensus hamper our understanding of that major evolutionary phenomenon. Here we address this issue by (i) reviewing the approaches used to quantify the phylogenetic selectivity of extinctions and extinction risks; (ii) investigating with a high-resolution dataset whether extinctions and survivals were phylogenetically clustered among early Pliensbachian (Early Jurassic) ammonites; (iii) exploring the phylogene…
Exercise respiratory cycle time components in patients with emphysema
2012
Background: We have recently demonstrated that in patients with COPD the severity of emphysema (E) measured by high resolution computed tomography (HRCT) correlated with: ratio VTpeak/FEV1; VE/VCO2 slope and PETCO2 values at peak exercise. The aim of this study was to further investigate if exercise respiratory cycle time components correlated with % of E measured by HRCT. Method: Twelve patients (age = 65±8 yrs; FEV1 = 55±17%pred) with moderate to severe E (quantified by lung HRCT as % voxels 50% and <50%), we observed that patients with higher % of E had longer TeM (TeM: 1,72±0,26sec vs 1,34±0,27sec, p = 0,005) and TeM-end. A good linear correlation has been observed also between TeM and …
Joint route planning under varying market conditions
2007
PurposeTo provide empirical evidence on the level of savings that can be attained by joint route planning and how these savings depend on specific market characteristics.Design/methodology/approachJoint route planning is a measure that companies can take to decrease the costs of their distribution activities. Essentially, this can either be achieved through horizontal cooperation or through outsourcing distribution to a logistics service provider. The synergy value is defined as the difference between distribution costs in the original situation where all entities perform their orders individually, and the costs of a system where all orders are collected and route schemes are set up simulta…
David Malcolm Raup (1933-2015) at the starting point of a new paradigm for Palaeontology
2020
This is a tribute to the late David Malcolm Raup, one of the major palaeontologists of the second half of the 20 th century. In addition, it is a critical review of his outstanding contributions, mainly in the field of theoretical palaeontology: quantitative modelling, the introduction of probabilistic methods in palaeontology, as well as his great imagination to use techniques from other fields, such as insurance actuary. After a general outline of his youth, I present a general depiction of the main topics of his research as a palaeobiologist: morphology, the structure of the fossil record, evolution, and extinction. He covered areas ranging from the theoretical morphology of coiled shell…