Search results for " Tradition"
showing 10 items of 360 documents
Natural Products Derived from Traditional Chinese Medicine as Novel Inhibitors of the Epidermal Growth Factor Receptor
2010
The epidermal growth factor receptor (EGFR) has become an important molecular target in cancer therapy. Various small molecules and therapeutic antibodies targeting EGFR family members have been developed during recent years and are established in clinical oncology. However, increasing clinical application of EGFR tyrosine kinase inhibitors has resulted in the development of resistance to EGFR-targeting drugs due to the selection of EGFR-mutated variants. This phenomenon forced the search for novel EGFR inhibitors with activity towards EGFR-mutant tumors. This review describes recent achievements in natural products derived from medicinal plants as novel EGFR inhibitors.
Traditional Chinese medicines (TCMs) for molecular targeted therapies of tumours.
2009
Scientific progress in genetics, cell and molecular biology has greatly ameliorated our comprehensive understanding of the molecular mechanisms of neoplastic transformation and progression. The rapidly advancing identification of molecular targets in human cancers during the last decade has provided an excellent starting point for the development of novel therapeutics. A huge variety of potential molecular targets have been identified, many of which are already in the market for therapeutic purposes. It is now becoming possible to target pathways and/or molecules that are crucial in maintaining the malignant phenotype. Traditional Chinese medicine (TCM) is often considered as alternative or…
Biopiracy versus One-World Medicine-From colonial relicts to global collaborative concepts.
2017
Abstract Background Practices of biopiracy to use genetic resources and indigenous knowledge by Western companies without benefit-sharing of those, who generated the traditional knowledge, can be understood as form of neocolonialism. Hypothesis The One-World Medicine concept attempts to merge the best of traditional medicine from developing countries and conventional Western medicine for the sake of patients around the globe. Study design Based on literature searches in several databases, a concept paper has been written. Legislative initiatives of the United Nations culminated in the Nagoya protocol aim to protect traditional knowledge and regulate benefit-sharing with indigenous communiti…
The Hydraulic space of the Conca d'Oro of Palermo as a paradigm of the Mediterranean water sensitive city.
2016
The orchards TAL on Palermo periurban countryside follows the Arab conception of hydraulic space. The concept of Hydraulic space combines several technologies to achieve the best use of water resources by differentiating agricultural productions in time and space and by connecting different functions (hydraulic, climatic and aesthetic) in a homogeneous system. This conception of space extends to the whole Conca d’Oro across the countryside to the heart of the historical town to the intimate domestic space in the end. During the Norman age the Zisa source used to refresh and embellish the interior of the castle before water slides towards the gardens; on the surface of Fawara-Maredolce lake …
Joseph Conrad-Korzeniowski, czyli polska dusza w literaturze angielskiej
2016
Joseph Conrad wniósł do literatury angielskiej prawdziwie polską duszę i fantazję. Ostatni z polskich romantyków, jak sam siebie nazwał, wprowadził do światowej literatury polskie dylematy, rozterki i wątpliwości, a także tęsknoty i pragnienia. Conrad przeniósł polskie doświadczenie na poziom uniwersalny i takim owo doświadczenie również uczynił. Rozmaite relacje współczesnych ukazują, jak niejednokrotnie trudno było odnaleźć się Polakowi w anglosaskiej rzeczywistości, i z jakimi przeciwnościami musiał się zmierzyć.
Conrad Andrzeja Buszy
2019
The article presents Professor Andrzej Busza, a Conradian researcher, who is connected with the subject of his research, Joseph Conrad, by common experiences of alienation and growing into a different culture, life on the border of different worlds. Busza presents Conrad’s Polish heritage and its later influence on the writer’s work. Busza writes about Conrad ’s deep pessimism, which links the writer with contemporary Poles, as well as about Conrad’s popularity during the war and occupation, when“ fidelity becomes the greatest of virtues, and betrayal - the greatest crime” . Busza also speaks of Conrad’s attitude to Flaubert and Dostoyevsky, which, being fuli of paradoxes and contradictions…
The pharmacology of the genus Sophora (Fabaceae): An updated review.
2019
Abstract Background The genus Sophora (Fabaceae) represents one of the important medicinal plant genera regarding its chemical constituents and outstanding pharmacological activities. Purpose In this review, we surveyed the latest findings on the bioactivities of different Sophora extracts and isolated phytochemicals during the past 8 years (2011–2019) updating the latest review article in 2011. The aim of this review is to focus on the molecular pharmacology of Sophora species to provide the rationale basis for the development of novel drugs. Results Sophora and its bioactive compounds possess outstanding pharmacological properties, especially as anticancer and anti-inflammatory drugs, in …
Corallaria
2021
Prima delle sette commedie composte dall’umanista ferrarese Tito Livio Frulovisi (1400-1463 c.), la Corallaria è caratterizzata da un doppio intreccio, entro il quale si individuano frequenti contaminazioni fra temi di tradizione comica classica e motivi di origine novellistica. Rappresentata a Venezia nel 1432, probabilmente da una compagnia di attori professionisti, la Corallaria si configura come una commedia “stataria”, dal momento che la maggiore parte degli eventi che vi si verificano, piuttosto che direttamente rappresentata, viene raccontata dai personaggi. Il titolo, di stampo evidentemente plautino, deriva dai coralli che il giovane Miles si fa prestare da Faceto e regala alla vec…
Minestre siciliane e un osservato speciale: la minestra di tenerumi
2020
Questo capitolo prende in esame una famiglia di pietanze che ha ampia diffusione in Italia e in Sicilia, quella delle minestre. Il termine minestra, di difficilissima traduzione, raccoglie piatti talvolta molto diversi tra loro fino ad accomunare, nei ricettari meno recenti, tutti i primi piatti italiani. Nel capitolo sarà approfondito il problema della vaghezza semantica del termine e prenderemo in esame una delle minestre siciliane più note: la "minestra di tenerumi", caratterizzata dalla presenza di un ingrediente autoctona, la cucuzza lunga con le sue foglie. La presenza di quest'ingrediente contribuisce a stabilizzare l'identità del piatto, da un lato, e a sancirne la tipicità e, dunqu…
Come si fa una cucina regionale. Semiotica del gusto e gastrosfera siciliana
2020
Questo capitolo affronta il tema della cucina regionale in chiave semiotica e introduce un caso di analisi specifico: la gastronomia siciliana. Dopo una breve ricostruzione degli studi storici, antropologici e sociali che si sono occupati dell'argomento, il capitolo procede alla composizione di un corpus di ricettari siciliani che sarà oggetto di analisi nel resto del volume. In chiave semiotica, il genere testuale del ricettario regionale costituisce uno dei principali veicoli di costruzione e circolazione delle cucine regionali e rappresenta, oltre che un oggetto di analisi complesso e sfidante, anche uno strumento di costruzione politica della regionalità: il ricettario seleziona e filtr…