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RESEARCH PRODUCT

The pharmacology of the genus Sophora (Fabaceae): An updated review.

Abdel Nasser B. SingabAhmed M. ElissawyShaza H. AlyOmayma A. EldahshanThomas EfferthMohamed A. El-shanawany

subject

Conventional medicineAntifungalSophoramedicine.drug_classPhytochemicalsAnti-Inflammatory AgentsPharmaceutical SciencePharmacologyBiologyAntioxidants03 medical and health sciences0302 clinical medicineAnti-Infective AgentsGenusDrug DiscoverymedicineAnimalsHumans030304 developmental biologyPharmacology0303 health sciencesPlants MedicinalPlant ExtractsMolecular PharmacologyFabaceaebiology.organism_classificationAntineoplastic Agents PhytogenicComplementary and alternative medicineDrug development030220 oncology & carcinogenesisChemical constituentsEthnopharmacologyMolecular MedicineMedicine TraditionalSophora

description

Abstract Background The genus Sophora (Fabaceae) represents one of the important medicinal plant genera regarding its chemical constituents and outstanding pharmacological activities. Purpose In this review, we surveyed the latest findings on the bioactivities of different Sophora extracts and isolated phytochemicals during the past 8 years (2011–2019) updating the latest review article in 2011. The aim of this review is to focus on the molecular pharmacology of Sophora species to provide the rationale basis for the development of novel drugs. Results Sophora and its bioactive compounds possess outstanding pharmacological properties, especially as anticancer and anti-inflammatory drugs, in addition to its antioxidant, antibacterial, antifungal and antiviral properties. Conclusion Based on their use in traditional medicine, Sophora species exert a plethora of cellular and molecular activities, which render them as attractive candidates for rationale drug development. Randomized, placebo-controlled clinical trials are required for further integration of Sophora-based phototherapies into conventional medicine.

yearjournalcountryeditionlanguage
2019-04-28Phytomedicine : international journal of phytotherapy and phytopharmacology
10.1016/j.phymed.2019.153070https://pubmed.ncbi.nlm.nih.gov/31514082