Search results for " Transformation"
showing 10 items of 1043 documents
Mitochondrial localization and temporal expression of the Drosophila melanogaster DnaJ homologous tumor suppressor Tid50
1998
The Drosophila melanogaster tumor suppressor gene lethal(2)tumorous imaginal discs (tid) was identified as a homolog of all dnaJ-like genes known to date which have been well preserved in evolution. Homozygous D. melanogaster l(2)tid mutants l(2)tid1, l(2)tid2 and l(2)tid3 are characterized by neoplastic transformation of the adult integumental primordia, the imaginal discs, and the death at the time of puparium formation. The first part of this study is concerned with the identification and subcellular localization of the l(2)tid-encoded protein, Tid50. The second part examines its tissue specific expression during wild-type development and in tumorous imaginal discs. To specify the functi…
A temperature-sensitive brain tumor suppressor mutation of Drosophila melanogaster: Developmental studies and molecular localization of the gene
1993
The recessive-lethal, temperature-sensitive (ts) mutation of the tumor suppressor gene lethal(3)malignant brain tumor (l(3)mbt) causes in a single step the malignant transformation of the adult optic neuroblasts and ganglion mother cells in the larval brain at the restrictive temperature of 29 degrees C. The transformed cells are differentiation-incompetent and grow autonomously in a lethal and invasive fashion in situ in the brain as well as after transplantation in vivo into wild-type adult hosts. The imaginal discs show epithelial overgrowth. At the permissive temperature of 22 degrees C development is completely normal. The ts-period of gene activity responsible for 100% brain tumor sup…
Overexpression of the truncated form of high mobility group a proteins (HMGA2) in human myometrial cells induces leiomyoma-like tissue formation
2014
The pathogenesis of uterine leiomyomas, the most common benign tumor in women, is still unknown. This lack of basic knowledge limits the development of novel non-invasive therapies. Our group has previously demonstrated that leiomyoma side population (SP) cells are present in tumor lesions and act like putative tumor-initiating stemcells in human leiomyoma. Moreover, accumulated evidence demonstrates that these benign tumors of mesenchymal origin are characterized by rearrangements of the High Mobility Group A proteins (HMGA). In this work, we tested the hypothesis that leiomyoma development may be due to overexpression of HMGA2 (encoding high mobility group AT-hook2) in myometrial stem cel…
Management of Distribution Risks and Digital Transformation of Insurance Distribution—A Regulatory Gap in the IDD
2021
The Insurance Distribution Directive (IDD) aims to regulate insurance distribution in the EU regardless of distribution channels and means. Although new technologies affect insurance distribution, the IDD does not explicitly regulate this digital transformation. Insurers and intermediaries must comply with detailed business conduct rules that aim to counteract distribution risks. However, the IDD exempts ancillary insurance intermediaries from its scope when they meet certain conditions. The article highlights the regulatory framework on insurance, requiring insurers and intermediaries to address distribution risks, and analyses how this exemption affects the management of distribution risk…
Review of sustainable solar hydrogen production using photon fuel on artificial leaf
2017
Abstract Energy conversion from the renewable energy sources with suitable energy storage plays a vital role in the sustainable development. Sustainable hydrogen production from the solar energy is well suited for energy storage applications because of inherent high mass energy density of hydrogen. This manuscript reviewing the techniques required for the sustainable solar hydrogen production using photon fuel on artificial leaf, i.e. solar cell. The designing and assembling of artificial solar leaf, which is the replica of natural leaf and capable of harnessing full solar spectrum, are deliberated. This technology for sustainable solar hydrogen production will overlay a viable way for more…
Conservative swept volume boundary approximation
2010
We present a novel technique for approximating the boundary of a swept volume. The generator given by an input triangle mesh is rendered under all rigid transformations of a discrete trajectory. We use a special shader program that creates offset geometry of each triangle on the fly, thus guaranteeing a conservative rasterization and correct depth values. Utilizing rasterization mechanisms and the depth buffer we then get a conservative voxelization of the swept volume (SV) and can extract a triangle mesh from its surface. This mesh is simplified maintaining conservativeness as well as an error bound measured in terms of the one-sided Hausdorff distance. For this we introduce a new techniqu…
Broken rotor bars detection via Park's vector approach based on ANFIS
2014
Many attempts have been made on fault diagnosis of induction motors based on frequency and time domain analysis of stator current. In this paper, first the Park's vector transformation and frequency analysis for fault detection of induction motors are introduced. Then a smart approach using Adaptive Neuro Fuzzy Inference System (ANFIS) is proposed. This approach uses the time domain features derived from the Park's vector transformation of stator current. By the proposed method, a partial break including 5 mm crack on a bar, one broken bar and two broken bars using experimental data are investigated. It will be shown that features derived from Park's vector compared to features obtained fro…
On the Efficacy of PCM to Shave Peak Temperature of Crystalline Photovoltaic Panels: An FDM Model and Field Validation
2013
The exploitation of renewable energy sources and specifically photovoltaic (PV) devices have been showing significant growth; however, for a more effective development of this technology it is essential to have higher energy conversion performances. PV producers often declare a higher efficiency respect to real conditions and this deviation is mainly due to the difference between nominal and real temperature conditions of the PV. In order to improve the solar cell energy conversion efficiency many authors have proposed a methodology to keep the temperature of a PV system lower: a modified crystalline PV system built with a normal PV panel coupled with a Phase Change Material (PCM) heat stor…
Analytical Investigation and Control System Set-up of Medium Scale PV Plants for Power Flow Management
2012
In the field of photovoltaic (PV) plants and energy conversion from renewable sources, a large part of the technical literature is more devoted to practical aspects (new solar cells, electrically driven PV panels, safety, reduction of parasitic currents, etc.) than to theoretical investigations. Despite this tendency, this paper presents a mathematical analysis of a medium scale photovoltaic power generation system connected to the distribution network and of its control system. In such a system, the conversion stage is unique due to the absence of a boost chopper. The conducted analysis leads to the interesting conclusion that the inverter used in the plant presents two degrees of freedom,…
A multiphysics approach to the design of a seawave energy conversion system
2008
This paper presents a multiphysics approach to the design of a seawave energy conversion system which consists of a both a permanent magnet linear generator directly coupled to sea waves and the related power electronics conversion system. The thermal, electromagnetic and circuital aspects are included in the proposed approach. In order to maximize energy extraction, the stochastic features of the energy source is considered in the mathematical model of the whole system. An optimization procedures which includes the stochastic features of the model is presented and a machine built on the basis of the results of this procedure is shown.