Search results for " Transformation"

FinTech in Latvia: Status Quo, Current Developments, and Challenges Ahead

2021

FinTech has been in the focus of discussion for quite some time. However, the market share of FinTech companies is still relatively small compared to that of more traditional financial services. The purpose of this paper is to analyse the status quo, current developments, and challenges ahead for the Latvian FinTech sector. We combine three analyses: a political and legal, economic, social, and technological environment (PEST) analysis

Standard classes on the blow-up of $\mathbb{P}^n$ at points in very general position

2012

Hypoxia-inducible factor 1 alpha expression increases during colorectal carcinogenesis and tumor progression

2008

Abstract Background Hypoxia-inducible factor 1 alpha (HIF-1α) is involved in processes promoting carcinogenesis of many tumors. However, its role in the development of colorectal cancer is unknown. To investigate the significance of HIF-1α during colorectal carcinogenesis and progression we examined its expression in precursor lesions constituting the conventional and serrated pathways, as well as in non-metastatic and metastatic adenocarcinomas. Methods Immunohistochemistry and Western blot is used to analyse HIF-1α expression in normal colonic mucosa, hyperplastic polyps (HPP), sessile serrated adenomas (SSA), low-grade (TA-LGD) and high-grade (TA-HGD) traditional adenomas as well as in n…

Transformation of primary human hepatocytes in hepatocellular carcinoma

2015

Hepatocellular carcinoma (HCC) is the most common primary liver cancer. Currently, there is limited knowledge of neoplastic transformation of hepatocytes in HCC. In clinical practice, the high rate of HCC local recurrence suggests the presence of different hepatocyte populations within the liver and particularly in the tumor proximity. The present study investigated primary human hepatocyte cultures obtained from liver specimens of patients affected by cirrhosis and HCC, their proliferation and transformation. Liver samples were obtained from seven HCC cirrhotic patients and from three patients with normal liver (NL). Immediately after surgery, cell outgrowth and primary cultures were obtai…

Stability of hydrodynamical relativistic planar jets : II. Long-term nonlinear evolution

2004

In this paper we continue our study of the Kelvin-Helmholtz (KH) instability in relativistic planar jets following the long-term evolution of the numerical simulations which were introduced in Paper I. The models have been classified into four classes (I to IV) with regard to their evolution in the nonlinear phase, characterized by the process of jet/ambient mixing and momentum transfer. Models undergoing qualitatively different non-linear evolution are clearly grouped in well-separated regions in a jet Lorentz factor/jet-to-ambient enthalpy diagram. Jets with a low Lorentz factor and small enthalpy ratio are disrupted by a strong shock after saturation. Those with a large Lorentz factor an…

Minkowski-Lorentz Spaces Applications: Resolution of Apollonius and Dupin Problems

2019

International audience

An Ester-Substituted Iridium Complex for Efficient Vacuum-Processed Organic Light-Emitting Diodes

2009

An orange-red-emitting iridium complex (N958) was prepared, and its photophysical and device-based characteristics were investigated. Despite N958 displaying quite poor photophysical properties in solution (acetonitrile), organic light-emitting diode (OLED) devices based on the complex exhibit an efficiency close to 10%.

Transcription factor NRF2 regulates miR-1 and miR-206 to drive tumorigenesis

2013

The mechanisms by which deregulated nuclear factor erythroid-2–related factor 2 (NRF2) and kelch-like ECH-associated protein 1 (KEAP1) signaling promote cellular proliferation and tumorigenesis are poorly understood. Using an integrated genomics and 13C-based targeted tracer fate association (TTFA) study, we found that NRF2 regulates miR-1 and miR-206 to direct carbon flux toward the pentose phosphate pathway (PPP) and the tricarboxylic acid (TCA) cycle, reprogramming glucose metabolism. Sustained activation of NRF2 signaling in cancer cells attenuated miR-1 and miR-206 expression, leading to enhanced expression of PPP genes. Conversely, overexpression of miR-1 and miR-206 decreased the exp…

pp32/PHAPI determines the apoptosis response of non-small-cell lung cancer

2007

During malignant transformation, cancer cells have to evade cell-intrinsic tumor suppressor mechanisms including apoptosis, thus acquiring a phenotype that is relatively resistant to clinically applied anticancer therapies. Molecular characterization of apoptotic signal transduction defects may help to identify prognostic markers and to develop novel therapeutic strategies. To this end we have undertaken functional analyses of drug-induced apoptosis in human non-small cell-lung cancer (NSCLC) cells. We found that primary drug resistance correlated with defects in apoptosome-dependent caspase activation in vitro. While cytochrome c-induced apoptosome formation was maintained, the subsequent …

Structure of equilibrium states on self-affine sets and strict monotonicity of affinity dimension

2017

A fundamental problem in the dimension theory of self-affine sets is the construction of high- dimensional measures which yield sharp lower bounds for the Hausdorff dimension of the set. A natural strategy for the construction of such high-dimensional measures is to investigate measures of maximal Lyapunov dimension; these measures can be alternatively interpreted as equilibrium states of the singular value function introduced by Falconer. Whilst the existence of these equilibrium states has been well-known for some years their structure has remained elusive, particularly in dimensions higher than two. In this article we give a complete description of the equilibrium states of the singular …