Search results for " Transformation"

showing 10 items of 1043 documents

Properties of nuclei in the nobelium region studied within the covariant, Skyrme, and Gogny energy density functionals

2015

We calculate properties of the ground and excited states of nuclei in the nobelium region for proton and neutron numbers of 92 <= Z <= 104 and 144 <= N <= 156, respectively. We use three different energy-density-functional (EDF) approaches, based on covariant, Skyrme, and Gogny functionals, each within two different parameter sets. A comparative analysis of the results obtained for odd-even mass staggerings, quasiparticle spectra, and moments of inertia allows us to identify single-particle and shell effects that are characteristic to these different models and to illustrate possible systematic uncertainties related to using the EDF modelling

Nuclear and High Energy Physics[PHYS.NUCL]Physics [physics]/Nuclear Theory [nucl-th]ProtonNuclear TheoryNuclear Theorychemistry.chemical_elementFOS: Physical sciences7. Clean energySpectral lineMoments of inertiaNuclear physicsNuclear Theory (nucl-th)NeutronCovariant transformationHeavy and superheavy nucleiPhysicsta114Odd–even mass staggeringMoment of inertiachemistryExcited stateQuasiparticleNobeliumQuasiparticle excitationsNuclear energy density functionalsNuclear masses
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Experiments on threshold pion electroproduction

2008

Experimental techniques to access the reactions p(e, e′ p)π0 and d(e, e′ d)π0 at low four momentum transfer and close to threshold are presented. For p(e, e′ p)π0 results at Q 2=0.1 GeV2/c 2 are given and compared to chiral perturbation theory. A new experimental program on d(e, e′ d)π0 is presented.

Nuclear physicsRecoil protonPhysicssymbols.namesakeParticle physicsTransfer (group theory)Chiral perturbation theoryPionLorentz transformationsymbolsFour-momentum
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Monotonic solution of heterogeneous anisotropic diffusion problems

2013

Anisotropic problems arise in various areas of science and engineering, for example groundwater transport and petroleum reservoir simulations. The pure diffusive anisotropic time-dependent transport problem is solved on a finite number of nodes, that are selected inside and on the boundary of the given domain, along with possible internal boundaries connecting some of the nodes. An unstructured triangular mesh, that attains the Generalized Anisotropic Delaunay condition for all the triangle sides, is automatically generated by properly connecting all the nodes, starting from an arbitrary initial one. The control volume of each node is the closed polygon given by the union of the midpoint of…

Numerical AnalysisPhysics and Astronomy (miscellaneous)Anisotropic diffusionDelaunay triangulationApplied MathematicsMathematical analysisMonotonic functionGeometryMidpointFinite element methodComputer Science ApplicationsSettore ICAR/01 - IdraulicaComputational MathematicsModeling and SimulationPolygonTriangle meshanisotropic diffusion heterogeneous medium M-matrix Delaunay mesh affine transformation edge swapGalerkin methodComputingMethodologies_COMPUTERGRAPHICSMathematics
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Cultural institutions as agents of urban and community regeneration in the (post-)pandemic city. The case of the «Laboratorio Zen Insieme» in Palermo

2022

Although all cities in the world have been affected by the COVID-19 pandemic, its impacts on the territories, yet to be understood, are unevenly distributed, revealing extremely varied imbalances depending on the places. However, it is clear that the virus and its variants have aggravated pre-existing socio-spatial inequalities, creating new ones and bringing attention back to those implications between space, planning, public health and citizenship that are at the origins of contemporary urbanism. In a reference framework in which the crisis is globalized but unequal and in the absence of a welfare system capable of responding to the urgencies of the most marginalized social contexts and g…

Olsen 2018Settore ICAR/21 - UrbanisticaSettore M-GGR/01 - GeografiaSacco and Blessi 2009). In the current (post-) pandemic context and through the lens of a southern European perspective the purpose of this article is to critically reflect about the role of culture as possible vehicle of urban and community regeneration. In particular we will focus on the activities of the no profit organization «Laboratorio Zen Insieme» in ZEN2 one of the last large popular and peripheral neighborhoods built in Palermo at the end of 80s in order to explore and understand how cultural practices work as agent of urban and social transformation capable of addressing emerging issues especially in the pandemic scenario we are experiencing. Thecasestudy has been conducted through analysis of documents participative observations (Honer and Hitzler 2015) and qualitative in-depth interviews with key actors involved in the conception organization and management of the activities carried out by Laboratorio Zen Insieme with representatives of local institutions and non-formal conversations with participants of the workshops heldin the neighborhood. The experience we narrate finds that cultural practices have re-conceptualized their design and functions as strategies of urban and community regeneration and at the same time have contributed to answer to emergent issues in developing proximity and local based strategies facing up to problems inherent civil rights educationalpoverty socio-spatial justice and have changed the image and identity of urban places they inhabit.In this sense the research provides a framework for development of strategies and legitimization for cultural practices and a point of discussionabouttheirrolein urban development.Although all cities in the world have been affected by the COVID-19 pandemic its impacts on the territories yet to be understood are unevenly distributed revealing extremely varied imbalances depending on the places. However it is clear that the virus and its variants have aggravated pre-existing socio-spatial inequalities creating new ones and bringing attention back to those implications between space planning public health and citizenship that are at the origins of contemporary urbanism. In a reference framework in which the crisis is globalized but unequal and in the absence of a welfare system capable of responding to the urgencies of the most marginalized social contexts and groups a response to the new social and individual needs has been offered by cultural institutions that play a role of territorial agency often independently or in the absence of political institutions. Far from the idea of entertainment and divertissement it is in fact increasingly clear how the practices of cultural innovation experimenting with various forms of action and participation can in some cases play a fundamental role in the processes of social cohesion and community building representing an antidote to the worsening of the phenomena of marginalization and socio-spatial inequalities within cities and territories (Colantonio and Dixon 2011
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Oncogene-Associated Growth Behavior and Oxygenation of Multicellular Spheroids from Rat Embryo Fibroblasts

1994

It is now well documented that naturally occurring and experimentally induced tumors develop by a multistep process involving different stages such as unlimited growth, metastasis, and invasiveness. There is much evidence that malignant transformation involves activation of oncogenes and/or loss of suppressor genes (= anti-oncogenes). The former fundamental class of genes, including the ras and myc families, are associated with cell proliferation and differentiation and may mediate tumor initiation, promotion and progression (for reviews see: Spandidos, 1985; Spandidos and Anderson, 1987, Weinberg, 1989).

OncogeneCell growthEmbryoTumor initiationBiologymedicine.diseaselaw.inventionMetastasisMalignant transformationlawmedicineCancer researchSuppressorGene
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Hypoxia and Aggressive Tumor Phenotype: Implications for Therapy and Prognosis

2008

Abstract Tumor hypoxia, mostly resulting from poor perfusion and anemia, is one of the key factors in inducing the development of cell clones with an aggressive and treatment-resistant phenotype that leads to rapid progression and poor prognosis. Studies in patients with solid tumors suggest that there is a range of hemoglobin (Hb) concentrations that is optimum for tumor oxygenation. When used to achieve an Hb level within this range, erythropoiesis-stimulating agents (ESAs) can be expected to increase tumor oxygenation, and this may favorably influence sensitivity to treatment as well as quality of life. There is no robust evidence that ESAs, when used as indicated, have a negative effect…

OncologyCancer Researchmedicine.medical_specialtyPathologyAnemiaCellHemoglobinsNeoplasmsInternal medicinemedicineHumansErythropoietinCell ProliferationTumor hypoxiabusiness.industryAnemiaCell DifferentiationHypoxia (medical)Tumor OxygenationHypoxia-Inducible Factor 1 alpha Subunitmedicine.diseasePhenotypeCell HypoxiaRecombinant ProteinsOxygenCell Transformation Neoplasticmedicine.anatomical_structureOncologyHematinicsHemoglobinmedicine.symptombusinessPerfusionThe Oncologist
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Tumorigenic and metastatic activity of human thyroid cancer stem cells

2010

Abstract Thyroid carcinoma is the most common endocrine malignancy and the first cause of death among endocrine cancers. We show that the tumorigenic capacity in thyroid cancer is confined in a small subpopulation of stem-like cells with high aldehyde dehydrogenase (ALDHhigh) activity and unlimited replication potential. ALDHhigh cells can be expanded indefinitely in vitro as tumor spheres, which retain the tumorigenic potential upon delivery in immunocompromised mice. Orthotopic injection of minute numbers of thyroid cancer stem cells recapitulates the behavior of the parental tumor, including the aggressive metastatic features of undifferentiated thyroid carcinomas, which are sustained by…

OncologyMaleCancer ResearchLung NeoplasmsPapillaryNudeMessengerThyroid GlandFluorescent Antibody TechniqueTYROSINE KINASEMice SCIDCell TransformationImmunoenzyme TechniquesMiceMice Inbred NODCell MovementAdenocarcinoma FollicularThyroid cancerRADIOACTIVE IODINETumor Stem Cell AssayEPITHELIAL-MESENCHYMAL TRANSITION; ALDEHYDE DEHYDROGENASE-ACTIVITY; ACUTE MYELOID-LEUKEMIA; RADIOACTIVE IODINE; TYROSINE KINASE; LUNG-CANCER; CARCINOMA; RECEPTOR; GROWTH; DIFFERENTIATIONBlottingReverse Transcriptase Polymerase Chain ReactionThyroidMiddle AgedProto-Oncogene Proteins c-metFlow CytometryEPITHELIAL-MESENCHYMAL TRANSITIONmedicine.anatomical_structureCell Transformation NeoplasticDIFFERENTIATIONOncologyNeoplastic Stem CellsAdenocarcinomaGROWTHFemaleStem cellWesternAdultmedicine.medical_specialtyBlotting WesternMice NudeACUTE MYELOID-LEUKEMIABiologyAdenocarcinomaSCIDALDEHYDE DEHYDROGENASE-ACTIVITYThyroid carcinomaYoung AdultLUNG-CANCERAdenocarcinoma Follicular; Adult; Aged; Aldehyde Dehydrogenase; Animals; Blotting Western; Carcinoma; Carcinoma Papillary; Case-Control Studies; Cell Adhesion; Cell Movement; Cell Proliferation; Cell Transformation Neoplastic; Female; Flow Cytometry; Fluorescent Antibody Technique; Humans; Immunoenzyme Techniques; Lung Neoplasms; Male; Mice; Mice Inbred NOD; Mice Nude; Mice SCID; Middle Aged; Neoplasm Invasiveness; Neoplastic Stem Cells; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-met; RNA Messenger; Reverse Transcriptase Polymerase Chain Reaction; Thyroid Gland; Thyroid Neoplasms; Tumor Stem Cell Assay; Xenograft Model Antitumor Assays; Young Adult; Cancer Research; OncologyCancer stem cellSettore MED/04 - PATOLOGIA GENERALEInternal medicinemedicineCell AdhesionAnimalsHumansNeoplasm InvasivenessRNA MessengerThyroid NeoplasmsALDH Human Thyroid Cancer Stem CellsAgedCell ProliferationNeoplasticRECEPTORCarcinomaFollicularTumor Stem Cell AssayCancerAldehyde Dehydrogenasemedicine.diseaseXenograft Model Antitumor AssaysCarcinoma PapillaryCase-Control StudiesInbred NODRNAProto-Oncogene Proteins c-akt
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Expression of cell cycle markers and human papillomavirus infection in oral squamous cell carcinoma: use of fuzzy neural networks.

2005

Our aim was to evaluate in oral squamous cell carcinoma (OSCC) the relationship between some cell cycle markers and HPV infection, conditionally to age, gender and certain habits of patients, and to assess the ability of fuzzy neural networks (FNNs) in building up an adequate predictive model based on logic inference rules. Eighteen cases of OSCC were examined by immunohistochemistry for MIB-1, PCNA and survivin expression; presence of HPV DNA was investigated in exfoliated oral mucosa cells by nested PCR (nPCR, MY09-MY11/GP5-GP6), and HPV genotype was determined by direct DNA sequencing. Data were analyzed by traditional statistics (TS) and FNNs. HPV DNA was found in 9/18 OSCCs (50.0 %) wi…

OncologyMaleCancer ResearchSurvivinmedicine.disease_causeInhibitor of Apoptosis ProteinsRisk FactorsOral mucosaPapillomaviridaeAged 80 and overCell CycleSmokingHPV infectionAge FactorsAnatomical pathologyCell cycleMiddle AgedImmunohistochemistryNeoplasm Proteinsoral squamous cell carcinomamedicine.anatomical_structureCell Transformation NeoplasticOncologyCarcinoma Squamous CellImmunohistochemistryFemaleMouth NeoplasmscarcinogenesisMicrotubule-Associated ProteinsAdultmedicine.medical_specialtyBiologySex FactorsFuzzy LogicInternal medicineSurvivinmedicineHumanshuman papillomaviruAgedfuzzy neural networkGene Expression ProfilingPapillomavirus Infectionsmedicine.diseaseProliferating cell nuclear antigenstomatognathic diseasesImmunologyDNA Viralbiology.proteinNeural Networks ComputerCarcinogenesisInternational journal of cancer
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Vitamin D in cancer chemoprevention

2015

Context: There is increasing evidence that Vitamin D (Vit D) and its metabolites, besides their well-known calcium-related functions, may also exert antiproliferative, pro-differentiating, and immune modulatory effects on tumor cells in vitro and may also delay tumor growth in vivo. Objective: The aim of this review is to provide fresh insight into the most recent advances on the role of Vit D and its analogues as chemopreventive drugs in cancer therapy. Methods: A systematic review of experimental and clinical studies on Vit D and cancer was undertaken by using the major electronic health database including ISI Web of Science, Medline, PubMed, Scopus and Google Scholar. Results and conclus…

OncologyMalemedicine.medical_specialtyColorectal cancerPharmaceutical ScienceAntineoplastic AgentsBreast NeoplasmsPharmacologyChemopreventionMalignant transformationProstate cancerImmune systemBreast cancerInternal medicineNeoplasmsDrug DiscoverymedicineVitamin D and neurologyAnimalsHumansImmunologic FactorsVitamin DPharmacologyClinical Trials as TopicCancer preventionbusiness.industryCancerProstatic NeoplasmsGeneral Medicinemedicine.diseaseCancer cancer prevention calcitriol vitamin D vitamin D analoguesGrowth InhibitorsComplementary and alternative medicineSettore BIO/14 - FarmacologiaMolecular MedicineFemalebusinessColorectal Neoplasms
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Guidelines from the 2017 European Conference on Infections in Leukaemia for management of HHV-6 infection in patients with hematologic malignancies a…

2019

Of the two human herpesvirus 6 (HHV-6) species, human herpesvirus 6B (HHV-6B) encephalitis is an important cause of morbidity and mortality after allogeneic hematopoietic stem cell transplant. Guidelines for the management of HHV-6 infections in patients with hematologic malignancies or post-transplant were prepared a decade ago but there have been no other guidelines since then despite significant advances in the understanding of HHV-6 encephalitis, its therapy, and other aspects of HHV-6 disease in this patient population. Revised guidelines prepared at the 2017 European Conference on Infections in Leukaemia covering diagnosis, preventative strategies and management of HHV-6 disease are n…

Oncologymedicine.medical_specialtyHHV-6 Infectionmedicine.medical_treatmentvirusesHerpesvirus 6 HumanGraft vs Host DiseaseRoseolovirus InfectionsDiseaseHematopoietic stem cell transplantationAntiviral AgentsGuideline ArticleImmunocompromised HostInternal medicinemedicineCombined Modality TherapyHumansIn patientbiologybusiness.industryHematopoietic Stem Cell Transplantationvirus diseasesHematologybiochemical phenomena metabolism and nutritionbiology.organism_classificationmedicine.diseaseCell Transformation ViralCombined Modality TherapyEuropeTreatment OutcomeHematologic NeoplasmsPractice Guidelines as TopicHuman herpesvirus 6Allogeneic hematopoietic stem cell transplantbusinessEncephalitisHaematologica
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