Search results for " Transformation"
showing 10 items of 1043 documents
Risk of pancreatic malignancy and mortality in branch-duct IPMNs undergoing surveillance: A systematic review and meta-analysis
2016
Abstract Background Safety of non-operative management for low-risk branch-duct intraductal papillary mucinous neoplasms (BD-IPMNs) is debated. Aim To perform a systematic review/meta-analysis to determine their risk of developing pancreatic malignancy and of pancreatic malignancy-related deaths. Methods A MEDLINE search was performed and methodology was based on PRISMA statement. Incidence rates of overall pancreatic malignancy, malignant BD-IPMN, IPMN-distinct PDAC, and of pancreatic malignancy-related death rates were calculated by dividing the total number of events by the total number of person-years (pyrs) of follow-up. Heterogeneity was determined by I2 statistic. Results 20 studies …
Early diagnosis, clinical management, and follow-up of cardiovascular events with ponatinib
2020
Chronic myeloid leukemia (CML) is a myeloproliferative disorder characterized by neoplastic transformation of pluripotent cells due to a typical cytogenetic and molecular mutation known as Philadelphia (Ph) chromosome. In 2001, the introduction of the tyrosine kinasis inhibitor (TKI) imatinib as a therapeutic strategy for CML with PH chromosome mutation represented an important step towards treatment of these patients, and nowadays, this drug represents the gold therapeutic standard in this clinical setting. A second generation of TKIs (dasatinib, nilotinib, and bosutinib) showed an effective action in all patients with mutations resistant to imatinib. Ponatinib is a third-generation TKI an…
MicroRNAs and their role in the malignant transformation of oral leukoplakia: a scoping review
2021
Background MiRNAs are small non-coding RNAs that regulate gene expression at the post-transcriptional level and have been associated with malignant transformation of oral epithelial precursor lesions such as oral leukoplakia. The aim was to perform a scoping review of the contemporary literature about the different roles of miRNAs during the malignant transformation of oral leukoplakia. Material and Methods We conducted a systematic search with the following MeSH terms: ‘oral leukoplakia’, ‘carcinoma in situ’, ‘microRNAs’, ‘mouth neoplasms’ and ‘epithelial–mesenchymal transition’ in PubMed/MEDLINE, EMBASE and SpringerLink. Results Fifteen articles were included for analysis, among which in …
Preventing technostress through positive technology
2018
Over the past decade, the workplace has experienced significant changes as a result of Information and Communication Technologies (ICTs) and the subsequent digital transformation (Mcafee, 2006; Matt et al., 2015). Such technological, cultural, and organizational changes have redefined business models and competition. As evidenced by the shift from the Enterprise 1.0 to the Enterprise 2.0 business models, ICTs offer companies increased productivity and efficiency (Bilbao-Osorio et al., 2013). At the same time, introduction of ICTs can pose a threat to both a company and its employees through misuse, abuse, and overuse, resulting in technostress (Gaudioso et al., 2017). This emerging risk see…
Las influencias históricas y circunstancias sociales y sociológicas en la creación de estructuras sociales informales de naturaleza criminal: estudio…
2018
Essential elements cementing every community are the factors: ontological, structural, fixed mechanisms of conduct including moral, religious, legal, or traditional tradition, or tradition, which is the carrier of continuity of this community. Lack of social stabilization, which in the old days was caused, among other things, by often changing rulers, the lack of justice that would equally affect all social groups, or the grossly unfair distribution of goods between the various social groups, led to the emergence of informal organizations, These often replaced the official law or administration, in the area inhabited by some community
Deriguitque malis (Ov. Met. 6, 303). Litomorfosi e antropomorfosi nell'epos ovidiano
2003
Una lettura di stampo post-strutturalista degli episodi di trasformazione di uomini in pietra, e del loro inverso, nelle Metamorfosi ovidiane A post-structuralist reading of the episodes of Ovid's Metamorphoses where men are turned into stone, and vice versa.
The landscape of strongholds
2016
La difesa dei territori ha offerto risultati straordinari alla formazione e alla trasformazione del territorio e del paesaggio, a volte con tratti spettacolari e dimensioni incredibili. La celebrazione del centenario dell’inizio della Prima guerra mondiale ha offerto lo spunto per una riflessione sulle ricadute indotte sul paesaggio dagli eventi bellici, e più in generale dalla realizzazione di strutture difensive e del loro rapporto con il paesaggio circostante. Territorial defence led to extraordinary results in terms of forming and transforming the territory and landscape, at times with spectacular sights and incredible sizes. The one hundred year anniversary since the beginning of the F…
Virtual Synchronous Generator: An application to Microgrid Stability
2022
The objective of this paper is to illustrate an alternative control algorithm for power converters which have the task of introducing the energy generated by systems based on the use of renewable sources such as photovoltaic or wind power, into small-sized networks, microgrids. Virtual Synchronous Generator can operate both in parallel to the main network as well as in isolated and autonomous conditions (islanding-mode). The contribute of this work is to drive a consolidated approach, made in the time domain, in a more flexible and less time-consuming approach based on Park transformation
Test of Lorentz and CPT violation with short baseline neutrino oscillation excesses
2011
The sidereal time dependence of MiniBooNE ν[subscript e] and ν[over-bar][subscript e] appearance data is analyzed to search for evidence of Lorentz and CPT violation. An unbinned Kolmogorov–Smirnov (K–S) test shows both the ν[subscript e] and ν[over-bar][subscript e] appearance data are compatible with the null sidereal variation hypothesis to more than 5%. Using an unbinned likelihood fit with a Lorentz-violating oscillation model derived from the Standard Model Extension (SME) to describe any excess events over background, we find that the ν[subscript e] appearance data prefer a sidereal time-independent solution, and the ν[over-bar][subscript e] appearance data slightly prefer a sidereal…
A study of the Lorentz structure in tau decays
2000
This paper describes a measurement of the Michel parameters, \eta, \rho, \xi, \xi\delta, and the average \nu_{\tau} helicity, h_{\nu_{\tau}}, in tau lepton decays together with the first measurement of the tensor coupling in the weak charged current. The tau+tau- pairs were produced at the LEP e+e- collider at CERN from 1992 through 1995 in the DELPHI detector. Assuming lepton universality in the decays of the tau the measured values of the parameters were: \eta = -0.005 +/- 0.036 +/- 0.037, \rho = 0.775 +/- 0.023 +/- 0.020, \xi = 0.929 +/- 0.070 +/- 0.030, \xi\delta = 0.779 +/- 0.070 +/- 0.028, h_{\nu_{\tau}} = -0.997 +/- 0.027 +/- 0.011. The strength of the tensor coupling was measured to…