Search results for " Transformation"
showing 10 items of 1043 documents
Inhibition of expression of natural UAG suppressor glutamine tRNA in HIV-infected human H9 cells in vitro by Avarol.
1988
HTLV-IIIB-infected H9 cells are shown to contain a high level of the natural UAG suppressor glutamine tRNA(UmUG Gln); this tRNA has been demonstrated to be required for the synthesis of Moloney murine leukemia virus (Mo-MuLV)-encoded protease. After cultivation of HTLV-IIIB-infected H9 cells with Avarol at a concentration (1 microgram/ml), previously found to protect the cells against the cytopathic effects of HTLV-III, an almost complete inhibition of the synthesis of the tRNA(UmUG Gln) was observed. Moreover, we obtained some evidence that the processing of the HTLV-III precursor protein p53 to p24 is inhibited by Avarol in infected cells, suggesting that the compound interferes with the …
Riemann surfaces and Teichmüller theory
2017
Riemannin pinnat ja Teichmüller-teoriaa. Tämän työn päämääränä on määritellä Riemannin pintojen Teichmüller-avaruudet sekä tutkia niiden geometrisia ominaisuuksia. Ensin työssä kehitetään peiteavaruuksien ja toimintojen teoriaa, jota sovelletaan Möbius-kuvauksista koostuviin ryhmiin. Tämän jälkeen kvasikonformaalikuvaukset määritellään Riemannin pinnoille ja niiden yhteyttä yhdesti yhtenäisten Riemannin avaruuksien kvasikonformikuvauksiin tutkitaan. Näitä tietoja sekä yhdesti yhtenäisten Riemannin pintojen uniformisaatiolausetta hyödyntämällä todistetaan yleisten Riemannin pintojen uniformisaatiolause. Tämä tulos liittää pinnat Möbius-kuvauksien toimintoihin yhdesti yhtenäisillä Riemannin p…
Controversial issues in soft tissue solitary fibrous tumors: A pathological and molecular review
2019
The clinical evolution of solitary fibrous tumor (SFT) remains unclear. Although various clinical, morphological and molecular criteria may indicate increased risk of malignancy, some SFT can still progress despite having a clearly benign appearance. Various risk stratification systems have been proposed, but unfortunately they are not sufficient to precisely determine the malignant potential. In this review, we discuss current knowledge on SFT, focusing on the following controversial issues: (i) the diverse morphologic spectrum: 'the great simulator;' (ii) malignant transformation or dedifferentiation; (iii) current risk stratification systems; and (iv) molecular factors associated with cl…
Idées pour uné echoppe simple
2006
L’article propose une réflexion sur certaines questions récurrentes dans les villes européennes. Qui concerne la rénovation et les transformations des types de centres historiques et de leurs tissues, relatives aux nouvelles habitudes et aux nouvelles façons de vivre et d'habiter dans les villes. Les limes thèmes d'études liés à ces questions, concernent surtout des notions comme celles de comptabilité, d'adaptation, de mesure, de cohabitation, d'identité. Afin de trouver une nouvelle identité aux échoppes sans ignorer leur hérédité, la stratégie adoptée pour répondre aux questions du concours, se fonde essentiellement sur deux principes: 1) la reconnaissance et 1'adoption d'un système préc…
Signaling molecules: the pathogenic role of the IL-6/STAT-3 trans signaling pathway in intestinal inflammation and in colonic cancer.
2008
Although the precise etiology of inflammatory bowel diseases (IBD) still remains unclear, considerable progress has been made in the identification of novel signal transduction pathways that elucidate the immunopathogenesis involved in the perpetuation of the inflammatory process. As both ulcerative colitis and Crohn's disease are associated with an increased risk for developing colorectal cancer (CRC) and precancerous dysplastic epithelial changes, further studies have concentrated on finding a common signaling pathway that could serve as a mechanistic link between inflammation and associated colonic cancer in IBD. This review presents the current data concerning the pathogenic role of the…
Socs3 induction by PPARγ restrains cancer-promoting inflammation
2013
The presence of proinflammatory cytokines in the tumor microenvironment can support further growth of established cancers. Docosahexaenoic acid (DHA), a peroxisome proliferator-activated receptor-gamma (PPARγ) ligand, has been shown to suppress inflammation and limit tumor progression in vivo. Are the anticancer properties of DHA relying on its ability to prevent inflammation? If so, what are the molecular links between the anti-inflammatory properties of DHA and its anticancer effects? DHA is an n-3 polyinsaturated fatty acid mainly found in fish oil that was shown to contribute to inflammation resolution by preventing the release of proinflammatory mediators in vivo.1 DHA has also been as…
Salivary inflammatory proteins in patients with oral potentially malignant disorders
2019
Cytokines are a group of small proteins involved in the regulation of infection, immune responses and inflammation. Since altered cytokine responsiveness has been linked to Oral Squamous Cell Carcinoma (OSCC), research to date indicates the possibility of using salivary pro- and anti-inflammatory proteins for screening of oral disorders. OSCC is a multistep neoplasia in which many genetic and epigenetic changes have been correlated to cancerous transformation of oral potentially malignant disorders (OPMD) such as oral leukoplakia, erythroplakia and lichen planus. The goal of the innovative salivary diagnostics is the identification of a single or multiple biomarkers that will serve as a cli…
Invariant Feature Matching for Image Registration Application Based on New Dissimilarity of Spatial Features
2016
An invariant feature matching method is proposed as a spatially invariant feature matching approach. Deformation effects, such as affine and homography, change the local information within the image and can result in ambiguous local information pertaining to image points. New method based on dissimilarity values, which measures the dissimilarity of the features through the path based on Eigenvector properties, is proposed. Evidence shows that existing matching techniques using similarity metrics--such as normalized cross-correlation, squared sum of intensity differences and correlation coefficient--are insufficient for achieving adequate results under different image deformations. Thus, new…
Threshold Neutral Pion Photoproduction on the Proton
2015
The neutral pion photoproduction on the proton near threshold has a very small scattering cross section when compared to the charged channels, which in ChPT is explained by strong cancellations between the lowest order pieces. Therefore it is very sensitive to higher-order corrections of chiral perturbation theory. We perform a fully covariant calculation up to chiral order p^3 and we investigate the effect of the inclusion of the Delta(1232) resonance as an explicit degree of freedom. We show that the convergence improves, leading to a much better agreement with data at a wide range of energies.
Fast narrowing-driven partial evaluation for inductively sequential programs
2005
Narrowing-driven partial evaluation is a powerful technique for the specialization of (first-order) functional and functional logic programs. However, although it gives good results on small programs, it does not scale up well to realistic problems (e.g., interpreter specialization). In this work, we introduce a faster partial evaluation scheme by ensuring the termination of the process offline . For this purpose, we first characterize a class of programs which are quasi-terminating , i.e., the computations performed with needed narrowing—the symbolic computation mechanism of narrowing-driven partial evaluation—only contain finitely many different terms (and, thus, partial evaluation termi…