Search results for " Transformation"

Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor development.

2007

Pancreatic cancer is a disease with an extremely poor prognosis. Tumor protein 53-induced nuclear protein 1 ( TP53INP1 ) is a proapoptotic stress-induced p53 target gene. In this article, we show by immunohistochemical analysis that TP53INP1 expression is dramatically reduced in pancreatic ductal adenocarcinoma (PDAC) and this decrease occurs early during pancreatic cancer development. TP53INP1 reexpression in the pancreatic cancer-derived cell line MiaPaCa2 strongly reduced its capacity to form s.c., i.p., and intrapancreatic tumors in nude mice. This anti-tumoral capacity is, at least in part, due to the induction of caspase 3-mediated apoptosis. In addition, TP53INP1 −/− mouse embryonic…

HSP-MOLECULAR CHAPERONES IN CANCER BIOGENESIS AND TUMOR THERAPY: AN OVERVIEW

2012

Molecular chaperones, many of which are heat-shock proteins (HSPs), are an important class of molecules with various functions. Pathological conditions in which chaperones become etiological and/or pathogenic factors are called chaperonopathies, and are classified into by defect, by excess, and by "mistake". In the latter case, the chaperone is structurally and functionally normal but paqrtecipates in pathwais that favor diseases, aòlthough in some cases the chaperone may have post-translational modifications that may lead it to change its location and function and, thus, to become pathogenic. For example, HSP-chaperones are involved in acrcinogenesis in various ways, so that some forms of …

SHAKESPEARE AND THE ITALIAN RENAISSANCE: Appropriation, Transformation, Opposition.

2014

Pikosekunžu precizitātes laika intervālu mērīšanas un analīzes skaitlisko metožu izstrāde satelītu lāzerlokācijā pielietojumam

2002

Lāzerlokācijas metožu izmantošana zinātniskās programmās, kuras saistītas ar globālās ģeocentrisko koordinātu sistēmas definēšanu, Zemes rotācijas tekošo parametru noteikšanu, Zemes polu kustības mērījumiem, kontinentu dreifa noteikšanu, iespējamo zemestrīču prognozēšanu, prasa ļoti augstas precizitātes (0.5-2 cm) satelītu attālumu mērījumu rezultātus. Eksistējošie lāzeru tālmēri, daudzos gadījumos, nepilnīgi atbilst šīm prasībām, dodot precizitāti ap 4 cm. Risinot minētos lokācijas uzdevumus, liela loma ir laika intervālu analizatoru augstai izšķiršanas spējai. Satelītu lokācijā laika intervāla atsevišķa mērījuma vidējā kvadrātiskā kļūda nedrīkst pārsniegt dažus desmitus pikosekunžu, pie i…

Computing the Arrangement of Circles on a Sphere, with Applications in Structural Biology

2009

International audience; Balls and spheres are the simplest modeling primitives after affine ones, which accounts for their ubiquitousness in Computer Science and Applied Mathematics. Amongst the many applications, we may cite their prevalence when it comes to modeling our ambient 3D space, or to handle molecular shapes using Van der Waals models. If most of the applications developed so far are based upon simple geometric tests between balls, in particular the intersection test, a number of applications would obviously benefit from finer pieces of information. Consider a sphere $S_0$ and a list of circles on it, each such circle stemming from the intersection between $S_0$ and another spher…

Leaders’ Style, Self-Sacrifice, and Team Identification

2013

Leadership is a group feature that directly impacts on team identification. Effective leaders are especially capable of fostering group cohesiveness and promoting efficacy in goal attainment. We assessed the relationship between transactional and transformational leadership style, team identification, and leader self-sacrifice. Participants were 186 call center employees who were headed by a leader who operated with either a transactional or a transformational leadership style. The employees reported their level of team identification and leader self-sacrifice. Results show how, in either the transactional or transformational leadership condition, levels of leadership and self-sacrifice wer…

‘Landscape of exception’: Power inequalities and ethical planning challenges in the landscape transformation of south-eastern Sicily

2021

In some marginal contexts of Southern Italy, in light of specific economic, political and social conditions, certain relationships between ‘strong powers’ and ‘weak powers’ produce a suspension of norms/rights that is, paradoxically, ‘normalised’. This creates a particular spatial variation of Agamben’s (2005) state of exception concept: the ‘landscape of exception’. With respect to the possible conditions of ‘exception’, this article describes the ‘landscape of exception’ of the greenhouse system in South-Eastern Sicily. This ‘landscape of exception’ is generated by the greenhouses, in particular those dedicated to vegetable production, through an effective mechanism of spatial manipulati…

Leadership in virtual teams: a comparison of transformational and transactional leaders

2009

The effects of transactional and transformational leadership on groups in which people interact in a virtual manner were analyzed and specifically the level of satisfaction and perception of the style adopted were evaluated. Results indicated that a transformational style is more satisfying than a transactional style, and that a transformational leader is judged to be better than a transactional leader.

El lenguaje jurídico con perspectiva de género. Algunas reflexiones para la reforma constitucional

2019

Language shows culture and describes reality, but also the language allows you to retain and preserve the existing values, to maintain and perpetuate male values, which are patriarchal because society is patriarchal. Thus the language has served to contribute to the construction of that patriarchal culture. If the language has the power to create, it has the power to transform, therefore language can serve to build another type of relations and culture based on equality and consequently other more fair society. The construction of a more fair society depends in part on the use of another kind of language, language with gender perspective, and the overcoming of sexist and androcentric langua…

The public sector's roles in the sharing economy and the implications for public values

2019

Abstract Motivated by the growing significance of the sharing economy, we discuss the roles the public sector may play within the sharing economy and the corresponding implications for public values. The sharing economy represents a transformative agent for the public sector within the current landscape of digital transformation. While the public sector has so far acted mainly as a regulatory body in the sharing economy, we here discuss implications for other roles the public sector may take on, including the roles of customer, service provider, and platform provider. Framed within the context of the public value ideals (professional, efficiency, service, and engagement), we examine the opp…