Search results for " Trigger"

Interleukin-22 and interleukin-22-producing NKp44+ natural killer cells in subclinical gut inflammation in ankylosing spondylitis

2012

Objective The intestinal inflammation observed in patients with ankylosing spondylitis (AS) is characterized by an overexpression of interleukin-23 (IL-23). IL-23 is known to regulate IL-22 production through lamina propria NKp44+ natural killer (NK) cells, which are thought to be involved in protective mucosal mechanisms. This study was undertaken to evaluate the frequency of NKp44+ NK cells and the expression of IL-22 in the ileum of AS patients. Methods Tissue NKp44+ NK cells, NKp46+ NK cells, and IL-22–producing cells were analyzed by flow cytometry. Quantitative gene expression analysis of IL-22, IL-23, IL-17, STAT-3, and mucin 1 (MUC-1) was performed by reverse transcriptase–polymeras…

Effect of Soft Tissue Techniques on Headache Impact, Disability, and Quality of Life in Migraine Sufferers: A Pilot Study

2018

To determine the efficacy of suboccipital inhibitory techniques in people with migraine compared with a control treatment based on myofascial trigger point (MTrP) therapy and stretching.A randomized, double-blind controlled pilot trial was conducted.University research laboratory.Forty-six adults diagnosed with migraine with over 6 months duration.Participants were randomized to receive either combined MTrP therapy and stretching (control group) or the control treatment plus suboccipital soft tissue inhibition (experimental group). Treatment was applied on four occasions over 8 weeks (one every 15 days), with a duration of 30 minutes per session in the experimental group and 20 min in the c…

Changes in a patient with neck pain after application of ischemic compression as a trigger point therapy

2010

Objective To describe the immediate effects of ischemic compression (IC) as a trigger point therapy in a case of a patient with neck pain. The application of IC is a safe and effective method to successfully treat elicited myofascial trigger points. The purpose of this method is to deliberate the blockage of blood in a trigger point area in order to increase local blood flow. This washes away waste products, supplies necessary oxygen and helps the affected tissue to heal. In this case study, we treated a 27-year-old female patient with a medical report of neck pain for at least four months. The physical examination revealed a neck pain and stiffness at the left side and pain increases when …

ALICE forward rapidity upgrades

2017

Two forward rapidity upgrades of the ALICE apparatus at the LHC are presented: the Muon Forward Tracker (MFT) and the Fast Interaction Trigger (FIT). Their designs are driven by physics performance studies, which have been done using MC simulations. Several prototypes have been tested. Currently the detector design phase has ended. The final layouts, geometries and expected performance figures are presented. The latest developments from the test of the prototypes are discussed. The MFT will improve the performance of the ALICE Muon Spectrometer by adding vertexing capabilities to the system. The elementary component of the MFT is a Monolithic Active Pixel Sensor (MAPS), using the TowerJazz …

Event-Triggered Robust Control of an Integrated Motor-Gearbox Powertrain System for a Connected Vehicle under CAN and DOS-Induced Delays

2020

Inhibition of the NKp30 activating receptor by pp65 of human cytomegalovirus.

2005

Human cytomegalovirus, a chief pathogen in immunocompromised people, can persist in a healthy immunocompetent host throughout life without being eliminated by the immune system. Here we show that pp65, the main tegument protein of human cytomegalovirus, inhibited natural killer cell cytotoxicity by an interaction with the activating receptor NKp30. This interaction was direct and specific, leading to dissociation of the linked CD3zeta from NKp30 and, consequently, to reduced killing. Thus, pp65 is a ligand for the NKp30 receptor and demonstrates a unique mechanism by which an intracellular viral protein causes general suppression of natural killer cell cytotoxicity by specific interaction w…

Human NK cells selective targeting of colon cancer-initiating cells: a role for natural cytotoxicity receptors and MHC class I molecules

2013

Abstract Tumor cell populations have been recently proposed to be composed of two compartments: tumor-initiating cells characterized by a slow and asymmetrical growth, and the “differentiated” cancer cells with a fast and symmetrical growth. Cancer stem cells or cancer-initiating cells (CICs) play a crucial role in tumor recurrence. The resistance of CICs to drugs and irradiation often allows them to survive traditional therapy. NK cells are potent cytotoxic lymphocytes that can recognize tumor cells. In this study, we have analyzed the NK cell recognition of tumor target cells derived from the two cancer cell compartments of colon adenocarcinoma lesions. Our data demonstrate that freshly p…

Design of the online PC farm for the high level trigger of the NA62 experiment at CERN

2012

We present a highly efficient data processing framework optimized for software based triggers of fixed-target HEP experiments with continuous data collection during burst time alternating with longer out-of-burst periods.

Conceptual design of the TRACE detector readout using a compact, dead time-less analog memory ASIC

2015

[EN] The new TRacking Array for light Charged particle Ejectiles (TRACE) detector system requires monitorization and sampling of all pulses in a large number of channels with very strict space and power consumption restrictions for the front-end electronics and cabling. Its readout system is to be based on analog memory ASICs with 64 channels each that sample a View the MathML source window of the waveform of any valid pulses at 200 MHz while discarding any other signals and are read out at 50 MHz with external ADC digitization. For this purpose, a new, compact analog memory architecture is described that allows pulse capture with zero dead time in any channel while vastly reducing the tota…

Inducing efficient conditional cooperation patterns in public goods games, an experimental investigation

2010

This study analyses the behavior in a repeated public goods game when subjects know about the possibility of existence of strict conditional cooperators. We employed a baseline treatment and a threat treatment in which subjects are informed about the possibility of being in a group together with automata playing a grim trigger strategy. We conjecture the resulting game allows for almost fully efficient outcomes. Contributions in the threat treatment increase by 40% before a surprise restart, and by 50% after the surprise restart. In line with the grim trigger strategy subjects contribute either all or nothing in the threat treatment.