Search results for " Twin"
showing 10 items of 210 documents
Influence of long-term postmenopausal hormone-replacement therapy on estimated structural bone strength: A study in discordant monozygotic twins
2010
Although postmenopausal hormone-replacement therapy (HRT) is known to prevent fractures, knowledge on the influence of long-term HRT on bone strength and its determinants other than areal bone mineral density is scarce. This study used a genetically controlled design with 24 monozygotic female twin pairs aged 54 to 72 years in which one cotwin was using HRT (mean duration 8 years) and the other had never used HRT. Estimated bone strength, cross-sectional area, volumetric bone mineral density, bone mineral mass, and cross-sectional density and mass distributions were assessed in the tibial shaft, distal tibia, and distal radius with peripheral computed tomography (pQCT). In the tibial shaft,…
The world of twins: an update
2010
In last years, owing to the widespread availability of assisted-reproduction technology, multiple pregnancy rates in Western countries have increased. In twin pregnancies, an increased rate of gestational complications, intrauterine growth restriction (IUGR), preterm birth and severe perinatal conditions is present. These complications are more frequent in monozygotic twins compared to dizygotic twins as well as an increased relative risk of chromosomal abnormalities and congenital malformation. Monochorionic twins are at higher risk for complications, since they share a common placenta where an imbalance in unidirectional arteriovenous anastomoses can lead to twin#x2013;twin transfusion sy…
Hormone Replacement Therapy Associated White Blood Cell DNA Methylation and Gene Expression are Associated With Within-Pair Differences of Body Adipo…
2015
The loss of estrogen during menopause causes changes in the female body, with wide-ranging effects on health. Estrogen-containing hormone replacement therapy (HRT) leads to a relief of typical menopausal symptoms, benefits bone and muscle health, and is associated with tissue-specific gene expression profiles. As gene expression is controlled by epigenetic factors (including DNA methylation), many of which are environmentally sensitive, it is plausible that at least part of the HRT-associated gene expression is due to changes in DNA methylation profile. We investigated genome-wide DNA methylation and gene expression patterns of white blood cells (WBCs) and their associations with body compo…
EMAS position statement: Predictors of premature and early natural menopause.
2019
Simoncini, Tommaso/0000-0002-2971-0079; Chung, Hsin-Fang/0000-0003-3261-5942; Mishra, Gita/0000-0001-9610-5904 WOS:000468709100014 PubMed ID: 31027683 Introduction: While the associations of genetic, reproductive and environmental factors with the timing of natural menopause have been extensively investigated, few epidemiological studies have specifically examined their association with premature (< 40 years) or early natural menopause (40-45 years). Aim: The aim of this position statement is to provide evidence on the predictors of premature and early natural menopause, as well as recommendations for the management of premature and early menopause and future research. Materials and methods…
Theatrum niezwykłości w "Kronice wszytkiego świata" Marcina Bielskiego
2016
Praca dotyczy fenomenu niezwykłości w dawnych wiekach. Przedmiotem analizy stała się XVl-wieczna Kronika wszystkiego świata Marcina Bielskiego, która obfituje w bogaty materiał najrozmaitszych dziwów i cudowności. Struktura Kroniki Bielskiego współtworzy rodzaj theatrum, tj. kręgu wiedzy (gr. enkyklios paideia), gdzie realnie istniejące uporządkowane w przestrzeni rzeczy zostały nic tylko zinterpretowane i sklasyfikowane, ale też podporządkowane kategoriom zarówno systemu moralnego, jak i teologicznego. Wyłania się więc z encyklopedycznego dzieła Bielskiego świat pełen ładu, harmonii oraz sensu, taki, w którym swoje miejsce i znaczenie zyskuje każda nawet najbardziej nietypowa i dziwaczna r…
Twin-singleton differences among ESL students : a study of affective and cognitive factors at the age of 12
2001
Flooding in the Digital Twin Earth: The Case Study of the Enza River Levee Breach in December 2017
2023
The accurate delineation of flood hazard maps is a key element of flood risk management policy. Flood inundation models are fundamental for reproducing the boundaries of flood-prone areas, but their calibration is limited to the information available on the areas affected by inundation during observed flood events (typically fragmentary photo, video or partial surveys). In recent years, Earth Observation data have supported flood monitoring and emergency response (e.g., the Copernicus Emergency Service) thanks to the proliferation of available satellite sensors, also at high spatial resolution. Under this umbrella, the study investigates a levee breach that occurred in December 2017 along t…
Statistical analysis of the relation between metallic microstructures and mechanical properties
2020
This thesis aims at the development of physical relations between the intricate 3D features of metallic microstructures and the mechanical properties of the material. For understanding which are the microstructural determinants of the resultingmechanical behaviour of metals, a deep quantitative characterisation of the microstructure is needed. The main steps of quantitative characterisation of the microstructures are: identification of the phases distribution and their chemical composition, study of the microstructure morphology (geometrical arrangement of grains, grain boundaries, grain orientations, grain size and grain shape). An accurate description of the microstructure features enrich…
Cognitive Mimetics and Human Digital Twins : Towards Holistic AI Design
2023
AI is replacing and supporting people in many intelligence-requiring tasks. Therefore, it is essential to consider the conceptual grounds of designing future technical artefacts and technologies for practical use. We are developing two new practical design tools: cognitive mimetics and human digital twins for AI designers. Cognitive mimetics analyses human information processing to be mimicked by intelligent technologies. Human digital twins provide a tool for modelling what people do based on the results of cognitive mimetics. Together they provide a new way of designing intelligent technology in individual tasks and industrial contexts. nonPeerReviewed
Lesioni cutanee stellate e simmetriche in un gemello “rimasto solo”
2021
The incidence of multiple pregnancy has increased, particularly because of the advances in assisted reproductive technologies. Multiple gestations are high risk pregnancies, especially the monochorionic ones. Two/thirds of initially twin pregnancies result in singles at birth, a condition defined as vanishing twin syndrome. The intrauterine death of one of the twins can cause direct fetal damage to the surviving one on several levels. The paper describes the case of a child born from twin pregnancy that was interrupted for one of the co-twins at early second trimester of gestation who presented with aplasia cutis congenita.