Search results for " UPT"
showing 10 items of 308 documents
VEGF-B-induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart
2014
Abstract Angiogenic growth factors have recently been linked to tissue metabolism. We have used genetic gain‐ and loss‐of function models to elucidate the effects and mechanisms of action of vascular endothelial growth factor‐B (VEGF‐B) in the heart. A cardiomyocyte‐specific VEGF‐B transgene induced an expanded coronary arterial tree and reprogramming of cardiomyocyte metabolism. This was associated with protection against myocardial infarction and preservation of mitochondrial complex I function upon ischemia‐reperfusion. VEGF‐B increased VEGF signals via VEGF receptor‐2 to activate Erk1/2, which resulted in vascular growth. Akt and mTORC1 pathways were upregulated and AMPK downregulated, …
The study of myocardial viability after myocardial infarction: Valve and limitations of magnetic resonance imaging compared with myocardial scintigra…
1997
International audience; Abstract: The aim of this study was to compare myocardial thickness measured by magnetic resonance imaging and quantified fixation of thallium. Twenty-one patients 61.2+/-11 years were investigated after myocardial infarction of the anterior wall in 8 cases, inferior in 10 cases, lateral in 2 cases and apical in one case. The mean angiographic ejection fraction was 46.5 +/- 19 %. Myocardial scintigraphy was performed after an exercise or pharmacological stress test and followed by a study of redistribution. The data was analysed by a quantitative method. Magnetic resonance imaging was performed with Vertical and horizontal long axis views in systole and diastole with…
Glycolytic phenotype and AMP kinase modify the pathologic response of tumor xenografts to VEGF neutralization.
2011
Abstract VEGF antagonists are now widely used cancer therapeutics, but predictive biomarkers of response or toxicity remain unavailable. In this study, we analyzed the effects of anti-VEGF therapy on tumor metabolism and therapeutic response by using an integrated set of imaging techniques, including bioluminescence metabolic imaging, 18-fluorodeoxyglucose positron emission tomography, and MRI imaging and spectroscopy. Our results revealed that anti-VEGF therapy caused a dramatic depletion of glucose and an exhaustion of ATP levels in tumors, although glucose uptake was maintained. These metabolic changes selectively accompanied the presence of large necrotic areas and partial tumor regress…
Vesamicol blocks the recovery, by recycling cholinergic electromotor synaptic vesicles, of the biophysical characteristics of the reserve population.
1993
The effect of vesamicol on the ability of recycling cholinergic synaptic vesicles to recover, during a period of post-stimulation rest, the biophysical properties of the reserve pool was studied in prestimulated perfused blocks of the electric organ of the electric ray, Torpedo marmorata, a tissue rich in cholinergic synapses. The effect of the drug was analysed by high-resolution centrifugal density-gradient fractionation in a zonal rotor of the extracted vesicles. The two vesicle fractions were identified by their ATP and acetylcholine content and the recycled vesicles by their acquisition of [3H]acetylcholine derived from [3H]acetate in the perfusate. Vesamicol (10 microM) blocked the up…
Effects of Plastic Mulching and Basal Nitrogen Application Depth on Nitrogen Use Efficiency and Yield in Maize
2018
The demand for increased grain production to support population and consumption growth has led to increased interest in field management approaches that incorporate plastic mulching and fertilization management. The purpose of this study was to investigate the effects of plastic mulching and basal nitrogen (N)-fertilizer application depth on N balance estimations, N use efficiency (NUE) and maize yield. The experiment was conducted in 2014 and 2015 with six treatments: no N fertilizer and no mulching (CK), traditional broadcast N fertilizer with mulching (T0), basal N-fertilizer application at a depth of 6 cm with no mulching (T1), basal N-fertilizer application at a depth of 6 cm with plas…
Prise en eau par composites carbone/époxy et leur effet sur le comportement mécanique : application aux réparations de structures en composite par co…
2013
Le travail présenté dans ce mémoire avait pour objectif d’étudier le processus de la pénétration d'eau dans les composites en carbone/époxyde dans un premier temps, et dans un deuxième temps, d’étudier l’effet de la prise en eau par ces matériaux sur les performances mécaniques des composites et leur joints collés. L'intégration de ces phénomènes physiques dans la modélisation numérique est d'une grande importance dans la prédiction de la durabilité d’une structure en composite subissant un vieillissement hygrothermique. Par conséquent, ce travail consiste non seulement en des observations expérimentales, mais aussi en des simulations numériques. Des corrélations entre les résultats obtenus…
Cadmium availability at different soil pH to transgenic tobacco overexpressing ferritin
2003
International audience; Knowledge on physiological mechanisms and plant metabolism can be used to enhance metal uptake. The capacity to uptake metals of transgenic tobaccos overexpressing ferritin in plastids (P6) or in cytoplasm (C5) and a control tobacco (A) is assessed in three polluted soils from the same soil series, with a similar Cd content, but displaying pH from 5.8 to 7 (8b2, 8b3, S11). Differences in dry leave weight were not significant between the three tobaccos growing on each soil. Iron concentration in ferritin overexpression either in P6 or in C5 tobaccos increased only on the S11 soil, which had a soil pH 7, in comparison to A tobacco. In both 8b2 and 8b3 soils at pH lower…
Etude de la biodisponibilité d'oligosaccharides éliciteurs dans les tissus foliaires en vue de l'amélioration de leur efficacité contre le mildiou de…
2015
Etude de la biodisponibilité d'oligosaccharides éliciteurs dans les tissus foliaires en vue de l'amélioration de leur efficacité contre le mildiou de la vigne
Phytoextractors of metal(loid)s of the Italian flora: An Outline
Intensive farming, wastewater irrigation, mining, heavy industry, smelting procedures and improper waste disposal are some of the human activities that contribute to heavy metal soil contamination (Sharma et al. 2007; Khan et al. 2008; Yu et al. 2008). As heavy metals cannot be degraded by microorganisms and tend to remain in polluted sites for long periods of time, soil contamination by heavy metals represents a particular environmental concern and a serious threat to human health. Conventional soil remediation techniques, such as soil washing, excavation, in situ vitrification, solidification and stabilization, can be effectively employed in order to achieve remediation of heavy metal con…