Search results for " US"

Relationship Between Cannabis Use and Erectile Dysfunction: A Systematic Review and Meta-Analysis

2019

Globally, there is increasing usage and legalization of cannabis. In addition to its reported therapeutic effects, cannabis has several health risks which are not clearly defined. Erectile dysfunction (ED) is the most common male sexual disorder and there are plausible mechanisms linking cannabis use to ED. No attempt has been made to collate the literature on this topic. The aim of this review was to summarize the prevalence and risk of ED in cannabis users compared to controls. A systematic review of major databases from inception to January 1, 2019, without language restriction, was undertaken to identify studies investigating cannabis use and presence of ED. The analysis compared the p…

MTOR inhibitor-based combination therapies for pancreatic cancer

2018

Background: Although the mechanistic target of rapamycin (MTOR) kinase, included in the mTORC1 and mTORC2 signalling hubs, has been demonstrated to be active in a significant fraction of patients with pancreatic ductal adenocarcinoma (PDAC), the value of the kinase as a therapeutic target needs further clarification. Methods: We used Mtor floxed mice to analyse the function of the kinase in context of the pancreas at the genetic level. Using a dual-recombinase system, which is based on the flippase-FRT (Flp-FRT) and Cre-loxP recombination technologies, we generated a novel cellular model, allowing the genetic analysis of MTOR functions in tumour maintenance. Cross-species validation and pha…

El edificio gremial de los abaixadors o tundidores, en Valencia

2020

In the ?barri del mercat?, in the city of Valencia and very close to its Lonja, there is a building complex which is the object of this study. The research, carried out from the simple field of toponymy, to the constructive analysis, lead us to suppose that it is the building of the Valencian trade union of cloth-shearers. It can be seen how the building now camouflaged by other subsequent interventions, corresponds to a type that cannot be related to those usually built in the city of Valencia. Its origins clearly from the Valencian self-governing period splendor, its dimensions and the finishes used in its construction seem to refer to a medieval workshop. A structure of great importance …

The Recurrent Characteristics of Historic Buildings as a Support to Improve their Energy Performances: The Case Study of Palermo

2017

Abstract The analysis of the recurrent characteristics of the local historic architecture is useful to develop large-scale energy analyses, regulations and financial strategies, but also to support technical guidelines for an energy improvement balanced with conservation. For this purpose, a multi-scale methodology ranging from envelope components to the urban dimension is necessary. In the research here exposed, this approach is investigated by focusing on the historic architecture of Palermo. For this heritage, the collection of thermal and hygrometric data for envelope components is combined with the examination of representative constructions, based on building stock categorization. Int…

High Frequency Data Acquisition System for Modelling the Impact of Visitors on the Thermo-Hygrometric Conditions of Archaeological Sites: A Casa di D…

2018

[EN] The characterization of the microclimatic conditions is fundamental for the preventive conservation of archaeological sites. In this context, the identification of the factors that influence the thermo-hygrometric equilibrium is key to determine the causes of cultural heritage deterioration. In this work, a characterization of the thermo-hygrometric conditions of Casa di Diana (Ostia Antica, Italy) is carried out analyzing the data of temperature and relative humidity recorded by a system of sensors with high monitoring frequency. Sensors are installed in parallel, calibrated and synchronized with a microcontroller. A data set of 793,620 data, arranged in a matrix with 66,135 rows and …

Ocena zagrożeń obszarów Natura 2000 w województwie opolskim na podstawie struktury użytkowania terenu

2017

Dokonano oceny zagrożeń obszarów Natura 2000 ustanowionych na obszarze województwa opolskiego. Analizie poddano struktury użytkowania gruntów i pokrycia terenu 23 znajdujących się tam obszarów. Określono także potencjalny wpływ otoczenia, wyznaczając buforowe strefy oddziaływania, dla których także zbadano strukturę użytkowania i pokrycia terenu. Określono wskaźnik antropogenizacji obszarów uwzględniający podział na formy o charakterze naturalnym i seminaturalnym oraz antropogenicznym. Wskazano główne zagrożenia dla obszarów Natura 2000 województwa opolskiego. Z przeprowadzonych badań wynika, iż tereny te mają charakter w większości naturalny i seminaturalny. Głównym zagrożeniem dla tych ob…

EFL teachers talking about their use of computers at work : a discourse-analytic study

2003

Single-cell analysis of population context advances RNAi screening at multiple levels

2012

Isogenic cells in culture show strong variability, which arises from dynamic adaptations to the microenvironment of individual cells. Here we study the influence of the cell population context, which determines a single cell's microenvironment, in image‐based RNAi screens. We developed a comprehensive computational approach that employs Bayesian and multivariate methods at the single‐cell level. We applied these methods to 45 RNA interference screens of various sizes, including 7 druggable genome and 2 genome‐wide screens, analysing 17 different mammalian virus infections and four related cell physiological processes. Analysing cell‐based screens at this depth reveals widespread RNAi‐induce…

Student teachers and their identity construction and awareness of multilingualism: re-visiting three studies

2019

[EN] This article re-visits three studies that originally focused on beliefs about second language (L2) learning and teaching held by student teachers. The studies have been conducted in the same educational context (that is, at a Finnish university). The participants in the studies are majors or minors in English, Swedish, German, etc., and they range from first-year students to fifth-year students about to graduate as qualified L2 teachers. Data have been collected by a variety of means over the past few years (questionnaires, sentence-completion tasks, drawings), and partly longitudinally. The pools of data (verbal and visual) will be re-analysed from the perspective of identity construc…

Connecting the Language Classroom and the Wild : Re-enactments of Language Use Experiences

2018

AbstractUsing multimodal conversation analysis, this article analyses language learning as an in situ process during a teacher-assigned, experientially based pedagogical activity. The activity involved a three-part pedagogical structure, where learners first prepared for and then participated in real-life service encounters, and later reflected on their experiences back in the classroom. The analysis details how the co-constructed telling sequences through which novice second language users re-enact their experiences create an occasion for language-focused activity. We argue that the actions through which the participants display and sustain an orientation to an interactional practice as an…