Search results for " VAS"

Smeh Gogolâ v povesti "Zapiski sumasšedšego"

1998

Ženskie obrazy N. V. Gogolâ i F. M. Dostoevskogo

1998

The roles of the state and social licence to operate? Lessons from nuclear waste management in Finland, France, and Sweden

2019

The concept of social licence to operate (SLO) is an increasingly popular tool for companies to manage their relations with the local communities. SLO is very seldom used in the nuclear sector, which has nevertheless applied similar approaches, under notions such as partnership and participatory governance. This article explores the specific challenges that the application of SLO faces in the nuclear waste management (NWM) sector, by applying an often-used SLO framework of Boutilier and Thomson to illustrative case studies concerning nuclear waste repository projects in Finland, France and Sweden. Among the specificities of this sector, the article focuses on the central roles of the state …

Results of heart retransplantation: subanalysis of the Spanish Heart Transplant Registry

2021

Heart retransplantation (ReHT) is controversial in the current era. The aim of this study was to describe and analyze the results of ReHT in Spain. Methods We performed a retrospective cohort analysis from the Spanish Heart Transplant Registry from 1984 to 2018. Data were collected on donors, recipients, surgical procedure characteristics, immunosuppression, and survival. The main outcome was posttransplant all-cause mortality or need for ReHT. We studied differences in survival according to indication for ReHT, the time interval between transplants and era of ReHT. Results A total of 7592 heart transplants (HT) and 173 (2.3%) ReHT were studied (median age, 52.0 and 55.0 years, respectively…

MicroRNAs in solid organ and vascularized composite allotransplantation: Potential biomarkers for diagnosis and therapeutic use

2020

Abstract Nowadays, solid organ transplantation (SOT) is an established treatment for patients with end-organ dysfunction, which dramatically improves the quality-of-life. Vascularized composite allotransplants (VCAs) including hand and face have been reported worldwide over the last 20 years. However, VCAs, differently to SOT, are life-enhancing instead of life-saving and are not routinely performed due to the risk of immune rejection and the adverse effects of immunosuppression. Over the past decade, although considerable improvements in short-term outcomes after allotransplantation have been registered, these results have not been translated into major progress in long-term allograft acce…

Cytosolic Ca2+ and Phosphoinositide Hydrolysis Linked to Constitutively Active α1d-Adrenoceptors in Vascular Smooth Muscle

2003

In the present study, we analyzed changes in intracellular Ca2+ levels and inositol phosphate accumulation related to a population of alpha 1d-adrenoceptors in rat aorta resembling constitutively active receptors. Following intracellular Ca2+ store depletion by noradrenaline in Ca2+-free medium and removal of the agonist, restoration of extracellular Ca2+ induced four signals: a biphasic (transient and sustained) increase in [Ca2+]i, inositol phosphate accumulation, and a contractile response in the aorta. The transient increase in Ca2+, the inositol phosphate accumulation, and the contractile response were not observed in aortae incubated with prazosin or BMY 7378 [8-[2-[4-(2-methoxyphenyl…

The gut microbiota - a modulator of endothelial cell function and a contributing environmental factor to arterial thrombosis.

2019

Introduction: There is emerging evidence linking the commensal gut microbiota with the development of cardiovascular disease and arterial thrombosis. In immunothrombosis, the host clotting system protects against the dissemination of invading microbes, not considering the huge number of microbes that interact with host physiology in a mutualistic fashion. Areas covered: Interestingly, recent research revealed that colonizing gut microbes profoundly influence host innate immune pathways that support arterial thrombus growth. The gut microbiota promotes arterial thrombus formation by enhancing the pro-adhesive capacity of the vascular endothelium, triggering hepatic von Willebrand factor synt…

Das Krankheitsbild des doppelseitigen Carotisverschlusses

1974

An Hand von 10 eigenen Fallen wird das Krankheitsbild des doppelseitigen Carotisverschlusses dargestellt. Typische Verlaufsformen werden beschrieben. Am haufigsten sind: kontralaterale Hemiparese bei stummem einseitigem Verschlus, akute doppelseitige Symptomatik und langsam progrediente Hemisymptomatik. Die relativ geringe Bedeutung unblutiger Untersuchungsverfahren wird besprochen, nur die Angiographie kann die Diagnose sichern. Im klinischen Bild sollten auch diskrete beidseitige Symptome, ungewohnlich ausgepragte psychische Ausfalle oder auch eine verzogerte Ruckbildung der Ausfalle nach einem Insult an die Diagnose denken lassen. Die verschiedenen therapeutischen Konsequenzen werden bes…

P29.02: Assessment of placental vascularization by three-dimensional power Doppler to evaluate effect of mifepristone vs. placebo in early pregnancy

2007

Reperfusionsschock nach okklusion der A. mesenterica superior und akkumulation von leukozyten innerhalb der d�nndarmwand

1996

Der Epithelschaden und die Leukozytenakkumulation in der Wand des Ileums nach Ischamie und Reperfusion wurden experimentell am Schwein untersucht. Die A. mesenterica superior wurde fur 1 h (Gruppe 2; n=9), 2 h (Gruppe 3; n=6) und 3 h (Gruppe 4; n=7) abgeklemmt und 2 h reperfundiert. Die histologische Beurteilung erfolgte an Hamatoxylin-Eosin- und NaphtolAS-D-Chlorazetatesterase-gefarbten Praparaten. Es entwickelte sich ein Reperfusionsschock in Abhangigkeit von der Ischamiedauer. Nach lstundiger Ischamie stabilisierte sich der Blutdruck mit erniedrigten Werten sowie einer Normalisierung des Serumlaktatspiegels und des intramuralen pHi des Dunndarms. Eine Verlangerung der Ischamie auf 2 h (G…