Search results for " Variant"

Spatially variant dimensionality reduction for the visualization of multi/hyperspectral images

2011

International audience; In this paper, we introduce a new approach for color visu- alization of multi/hyperspectral images. Unlike traditional methods, we propose to operate a local analysis instead of considering that all the pixels are part of the same population. It takes a segmentation map as an input and then achieves a dimensionality reduction adaptively inside each class of pixels. Moreover, in order to avoid unappealing discon- tinuities between regions, we propose to make use of a set of distance transform maps to weigh the mapping applied to each pixel with regard to its relative location with classes' centroids. Results on two hyperspec- tral datasets illustrate the efficiency of…

On listening to atonal variants of two Piano Sonatas by Beethoven

2009

International audience; We investigated the contribution of tonal relationships to the perception of musical ideas and to the feelings of "arousal." Two excerpts of piano sonatas by Beethoven and two atonal variants were used as experimental stimuli. This manipulation destroyed the tonal relationships but preserved both the local and global temporal organization (rhythm and formal). Listeners were asked to indicate the onset of musical ideas, to estimate the arousing properties of the music in a continuous response task, and to rate the similarity of the pieces. A drastic change in the pitch structure strongly affected judgments of similarity. However, it had no effect on the segmentation o…

Wzorzec gatunkowy przewodnika turystycznego a realizacja tekstowa na przykładzie publikacji Jurija Nykołyszyna Lwów. Przewodnik

2021

W artykule przedstawiamy wyniki analizy realizacji tekstowej wzorca gatunkowego publikacji Jurija Nykołyszyna Lwów. Przewodnik. W części wstępnej przywołujemy teorię wzorca gatunkowego i jego wariantów kanonicznego, alternacyjnego i adaptacyjnego. Na tym tle pokazujemy przewodnik turystyczny jako gatunek. W kolejnych częściach omawiamy wyznaczniki gatunkowe analizowanego przewodnika: heterogeniczność, użytkowość, waloryzację i relacje nadawczo-odbiorcze. Analiza doprowadza do wniosku, że przewodnik Jurija Nykołyszyna jest wariantem alternacyjnym typowego przewodnika i charakteryzuje się jakościowymi i ilościowymi modyfikacjami kanonu.

Quantitative determination of casein genetic variants in goat milk: Application in Girgentana dairy goat breed

2016

The study was conducted to develop a high-performance liquid chromatographic (HPLC) method to quantify casein genetic variants (αs2-, β-, and κ-casein) in milk of homozygous individuals of Girgentana goat breed. For calibration experiments, pure genetic variants were extracted from individual milk samples of animals with known genotypes. The described HPLC approach was precise, accurate and highly suitable for quantification of goat casein genetic variants of homozygous individuals. The amount of each casein per allele was: αs2-casein A = 2.9 ± 0.8 g/L and F = 1.8 ± 0.4 g/L; β-casein C = 3.0 ± 0.8 g/L and C1 = 2.0 ± 0.7 g/L and κ-casein A = 1.6 ± 0.3 g/L and B = 1.1 ± 0.2 g/L. A good correl…

Catastrophic antiphospholipid syndrome in a patient with V Leiden variant

2012

Neurobiology of performance anxiety:A new approach

2016

The aim of this study is to investigate the neurobiology of stress/emotionality, creating a multidisciplinary assessment model, which can help to provide psychological and physiological responses depending on the genetic background related to sport performances, social closeness and performance anxiety management in team sports. We enrolled 20 female volleyball players aged 13 ± 1 years old played in two different teams during a regional championship final. Saliva collection was carried out before and after the match. In order to evaluate the neuroendocrine effectors involved in stress and performance, we analyzed cortisol and progesterone levels through Elisa standard kit as well as HSP70 …

Purification by affinity chromatography of H1 RNA-Binding Proteins from rat brain

2003

Post-transcriptional regulation of mRNA metabolism is involved in processes as different as cell fate specification in development and cell response to a large variety of environmental cues. Regulation of all steps of RNA metabolism depends on RNA-binding proteins (RBPs). By using a T1 RNase protection assay, we previously identified three H1° RNA-binding factors (p40, p70 and p110), highly expressed in the rat brain. Here we report enrichment of these factors from brain extracts, obtained by affinity chromatography of biotinylated H1° RNA-protein complexes on streptavidin-conjugated paramagnetic particles. The purified proteins maintain RNA-binding ability and preference for histone messag…

VARIANT HISTOLOGIC DIFFERENTIATION IN BLADDER CANCER TREATED WITH RADICAL CYSTECTOMY: INCIDENCE AND LONG TERM SURVIVAL IN A SINGLE INSTITUTION STUDY.

2016

LIMITS OF TRANSURETHRAL RESECTION IN DETECTING UNCOMMON HISTOLOGICAL VARIANTS WITHIN BULKY BLADDER TUMORS IN REAL-LIFE CLINICAL PRACTICE

2017

HER2 Signaling and Breast Cancer Stem Cells: The Bridge behind HER2-Positive Breast Cancer Aggressiveness and Therapy Refractoriness

2021

Simple Summary Breast cancer (BC) is not a single disease, but a group of different tumors, and altered HER2 expression defines a particularly aggressive subtype. Although HER2 pharmacological inhibition has dramatically improved the prognosis of HER2-positive BC patients, there is still an urgent need for improved knowledge of HER2 biology and mechanisms underlying HER2-driven aggressiveness and drug susceptibility. Emerging data suggest that the clinical efficacy of molecularly targeted therapies is related to their ability to target breast cancer stem cells (BCSCs), a population that is not only self-sustaining and able to differentiate into distinct lineages, but also contributes to tum…