Search results for " Variation"
showing 10 items of 1712 documents
Diabetes: Genetic variation underpins metformin response.
2016
Metformin is the first-line antidiabetic drug with over 100 million users worldwide, yet its mechanism of action remains unclear1. Here the Metformin Genetics (MetGen) Consortium reports a three-stage genome-wide association study (GWAS), consisting of 13,123 participants of different ancestries. The C allele of rs8192675 in the intron of SLC2A2, which encodes the facilitated glucose transporter GLUT2, was associated with a 0.17% (p=6.6×10−14) greater metformin-induced in haemoglobin A1c (HbA1c) in 10,577 participants of European ancestry. rs8192675 is the top cis expression quantitative trait locus (cis-eQTL) for SLC2A2 in 1,226 human liver samples, suggesting a key role for hepatic GLUT2 …
Intra-individual variability in TSH levels of healthy women during the first half of pregnancy
2017
TSH is the parameter most widely accepted to assess thyroid function, especially in pregnant women. The aim of this current study was to analyze intra-individual changes in TSH during the first half of pregnancy in women with TSH levels higher than 2.5mIU/L in early pregnancy.An observational, prospective study was conducted on 243 healthy pregnant women in the first trimester of pregnancy. Thyroid function was assessed by testing TSH and free T4 levels. A subgroup of women with TSH levels2.5mIU/L underwent additional tests (TSH, free T4, peroxidase antibodies). Information on dietary iodine intake and/or iodine supplements was also recorded.Mean TSH level was 1.89mIU/L (range 0.024-6.48mIU…
A Diffractive Reading
2023
AbstractTowards the end of the editing process, we started to see the book as something more than a collection of chapters around a theme: as an assemblage, which included, of course, the community of authors. When we put out the first call for contributions in May 2018, most authors volunteered a contribution rather quickly, others joined a bit later, and some dropped out for different reasons, underlining the dynamic nature of our assemblage. In pre-pandemic times, we met on and off campus, introduced some of our ideas at conferences, and had a workshop day to brainstorm, plan chapters, and reflect on the process and the purpose of the book. We were connected by common meals, jokes, writi…
Development of an individualized familiarization method for vertical jumps
2013
OBJETIVO: Propor um método de familiarização individualizado para saltos verticais e verificar o seu efeito na variabilidade intrassujeito. MÉTODOS: Cinquenta e três homes (média ± DP; idade 23,5 ± 3,3 anos; estatura 1,76 ± 0,08 m; massa 72,8 ± 8,6 kg; percentual de gordura 12,9 ± 5,2%) realizaram sucessivos saltos até atingir o nível de estabilidade proposto. Após 48 h este processo era repetido e a estabilidade entre dias era verificada, se necessário, mais sessões eram realizadas. O nível de estabilidade foi determinado por um teste z, com intervalo de confiança de 95%. Após o processo de familiarização, duas sessões experimentais adicionais foram realizadas para determinar a confiabilid…
A posteriori error identities for nonlinear variational problems
2015
A posteriori error estimation methods are usually developed in the context of upper and lower bounds of errors. In this paper, we are concerned with a posteriori analysis in terms of identities, i.e., we deduce error relations, which holds as equalities. We discuss a general form of error identities for a wide class of convex variational problems. The left hand sides of these identities can be considered as certain measures of errors (expressed in terms of primal/dual solutions and respective approximations) while the right hand sides contain only known approximations. Finally, we consider several examples and show that in some simple cases these identities lead to generalized forms of the …
FLUMO: FLexible Underwater MOdem
2019
The last years have seen a growing interest in underwater acoustic communications because of its applications in marine research, oceanography, marine commercial operations, the offshore oil industry and defense. High-speed communication in the underwater acoustic channel has been challenging because of limited bandwidth, extended multipath, refractive properties of the medium, severe fading, rapid time variation and large Doppler shifts. In this paper, we show an implementation of a flexible Software-Defined Acoustic (SDA) underwater modem, where modulation parameters are completely tunable to optimize performance. In particular, we develop the system architecture following two key ideas. …
Tras la pista del VIH: los estudios evolutivos y la comprensión del sida.
2013
El VIH o virus de la inmunodeficiencia humana tiene un gran impacto sanitario, social y económico; las terapias actuales permiten controlar la infección pero no se ha encontrado tratamiento curativo ni vacuna efectiva. Para conseguir estos objetivos, debe tenerse en cuenta la gran variabilidad genética y rápida evolución del VIH, asociadas, por ejemplo, a la aparición de variantes de resistencia a fármacos o de cambios antigénicos.
From Caristi’s Theorem to Ekeland’s Variational Principle in ${0}_{\sigma }$ -Complete Metric-Like Spaces
2014
We discuss the extension of some fundamental results in nonlinear analysis to the setting of ${0}_{\sigma }$ -complete metric-like spaces. Then, we show that these extensions can be obtained via the corresponding results in standard metric spaces.
Interindividual variability of food memory performance
2008
International audience; To investigate consumer's memory performance for a regularly product, 95 usual consumers of a precise soft-drink were invited to took part in a memory task, during which they were offered a series of samples, consisting in some samples identical to their favourite drink (target samples), and some samples slightly varying in sweetness, sourness of flavour intensity (distractor samples). (...)
Molecular phylogeny and ultrastructure of the lichen microalga Asterochloris mediterranea sp. nov. from Mediterranean and Canary Islands ecosystems
2015
The microalgae of the genus Asterochloris are the preferential phycobionts in Cladonia, Lepraria and Stereocaulon lichens. Recent studies have highlighted the hidden diversity of the genus, even though phycobionts hosting Cladonia spp. in Mediterranean and Canarian ecosystems have been poorly explored. Phylogenetic analyses were made by concatenation of the sequences obtained with a plastid -LSU rDNA- and two nuclear -ITS rDNA and actin- molecular markers of the phycobionts living in several populations of Cladonia convoluta-C. foliacea complex, C. rangiformis and C. cervicornis species widely distributed in these areas in a great variety of substrata and habitats. A new strongly supported …