Search results for " Variation"
showing 10 items of 1712 documents
Quantitative assessment of aortic stenosis by three-dimensional echocardiography
1997
The purpose of this study was to assess the feasibility of three-dimensional echocardiography in aortic stenosis. Planimetric determination of valve area and dynamic volume-rendered display were performed. Three-dimensional echocardiography permits display of any desired plane of the cardiac structure. Thus in the case of aortic stenosis, the plane used for planimetric evaluation can be positioned exactly through the valve orifice. Dynamic volume-rendered display may provide a spatial demonstration of the stenotic valve. In 48 patients aortic valve area was measured by planimetry. The three-dimensional data set was acquired by a workstation in the course of a multiplane transesophageal exam…
Intrasubject repeatability of corneal power, thickness, and wavefront aberrations with a new version of a dual rotating Scheimpflug–Placido system
2014
Purpose To determine the intrasubject repeatability of a recently introduced dual-camera rotating Scheimpflug–Placido imaging system (Galilei G4) in determining corneal thickness, power, and wavefront aberrations in young healthy subjects. Setting University of Valencia, Valencia, Spain. Design Prospective evaluation of diagnostic technology. Methods The study comprised right eyes of 25 subjects aged 20 to 40 years with a spherical equivalent ranging from −4.25 to +1.00 diopters. The central corneal thickness, thinnest point value and location, anterior and posterior surface curvatures, total corneal power, and corneal wavefront aberrations were measured for distance vision using the dual S…
Genetics and Beyond – The Transcriptome of Human Monocytes and Disease Susceptibility
2010
BACKGROUND: Variability of gene expression in human may link gene sequence variability and phenotypes; however, non-genetic variations, alone or in combination with genetics, may also influence expression traits and have a critical role in physiological and disease processes. METHODOLOGY/PRINCIPAL FINDINGS: To get better insight into the overall variability of gene expression, we assessed the transcriptome of circulating monocytes, a key cell involved in immunity-related diseases and atherosclerosis, in 1,490 unrelated individuals and investigated its association with >675,000 SNPs and 10 common cardiovascular risk factors. Out of 12,808 expressed genes, 2,745 expression quantitative trait …
Understanding the effect of window length and overlap for assessing sEMG in dynamic fatiguing contractions: A non-linear dimensionality reduction and…
2020
The Short-Time Fourier transform (STFT) is a helpful tool to identify muscle fatigue with clinical and sports applications. However, the choice of STFT parameters may affect the estimation of myoelectrical manifestations of fatigue. Here, we determine the effect of window length and overlap selections on the frequency slope and the coefficient of variation from EMG spectrum features in fatiguing contractions. We also determine whether STFT parameters affect the relationship between frequency slopes and task failure. Eighty-eight healthy adult men performed one-leg heel-rise until exhaustion. A factorial design with a window length of 50, 100, 250, 500, and 1000 ms with 0, 25, 50, 75, and 90…
The sound of music: differentiating musicians using a fast, musical multi-feature mismatch negativity paradigm.
2011
Abstract Musicians’ skills in auditory processing depend highly on instrument, performance practice, and on level of expertise. Yet, it is not known though whether the style/genre of music might shape auditory processing in the brains of musicians. Here, we aimed at tackling the role of musical style/genre on modulating neural and behavioral responses to changes in musical features. Using a novel, fast and musical sounding multi-feature paradigm, we measured the mismatch negativity (MMN), a pre-attentive brain response, to six types of musical feature change in musicians playing three distinct styles of music (classical, jazz, rock/pop) and in non-musicians. Jazz and classical musicians sco…
Repeatability of whole-cornea measurements using an anterior segment imaging device based on OCT and Placido-disk
2017
Current advances in refractive surgery require high accuracy of corneal measurements. We aim to evaluate the repeatability of topographic measurements using an integrated Placido disk - OCT device.Thirty right eyes of thirty healthy and young subjects were included. The topographic parameters of simulated keratometry, asphericity, minimum pachymetry, white-to-white distance, spherical aberration and corneal elevation were studied. Three measurements were taken by the same observer using the Visante omni device. The coefficient of repeatability (CoR), coefficient of variation (CoV) and intraclass correlation coefficient (ICC) were calculated to assess the repeatability. The Bland-Altman grap…
Precision of a commercial hartmann-shack aberrometer: limits of total wavefront laser vision correction.
2012
Purpose To assess the intrasession and intersession precision of higher-order aberrations (HOAs) measured using a commercial Hartmann-Shack wavefront sensor (Zywave; Bausch & Lomb) in refractive surgery candidates. Design Prospective, experimental study of a device. Methods To analyze intrasession repeatability, 1 experienced examiner measured 30 healthy eyes 5 times successively. To study intersession reproducibility, the same clinician obtained measurements from another 30 eyes in 2 consecutive sessions at the same time of day 1 week apart. Results For intrasession repeatability, excellent intraclass correlation coefficients (ICCs) were obtained for total ocular aberrations, total HOAs, a…
Assessment of the distal anastomosis of coronary artery bypass grafts with a 2D T2-weighted turbo spin echo sequence and correlation to conventional …
2005
Abstract Objective The aim of the study was to evaluate the patensies of the distal anastomoses of coronary artery bypass grafts and to detect graft stenoses and occlusions with a magnetic resonance (MR) spin echo sequence. Patients and methods One hundred and eighty-five patients with 481 distal anastomoses were examined with a 1.5 T MR scanner and coronary angiography. A 2-dimensional T2-weigthed breath-hold half-Fourier acquisition single-shot turbo spin echo sequence (Haste) was performed. All images were evaluated independently by a radiologist and cardiologist and compared to the conventional coronary angiography. The observers were blinded to the coronary angiography findings, but in…
Lithium and GSK3-β promoter gene variants influence white matter microstructure in bipolar disorder
2013
Lithium is the mainstay for the treatment of bipolar disorder (BD) and inhibits glycogen synthase kinase 3-beta (GSK3-beta). The less active GSK3-beta promoter gene variants have been associated with less detrimental clinical features of BD. GSK3-beta gene variants and lithium can influence brain gray matter structure in psychiatric conditions. Diffusion tensor imaging (DTI) measures of white matter (WM) integrity showed widespred disruption of WM structure in BD. In a sample of 70 patients affected by a major depressive episode in course of BD, we investigated the effect of ongoing long-term lithium treatment and GSK3-beta promoter rs334558 polymorphism on WM microstructure, using DTI and …
Determination of Bolton tooth-size ratios by digitization, and comparison with the traditional method.
2005
The Bolton Index is one of the most useful calculations for precise orthodontic diagnosis as it shows if there is a correct ratio between dental proportions. However, at times, this calculation is not applied because it is a long and time-consuming procedure compared with digital methods. A new digital method for measuring tooth sizes and for calculating the Anterior (ABI) and the Overall (OBI) Bolton Index was tested on 100 sets of study dental casts of the permanent dentition in a Spanish sample and compared with the traditional method. The reproducibility of this digital method versus the traditional one was analysed to determine intra- and inter-examiner measurement errors by calculatin…