Search results for " Variation"
showing 10 items of 1712 documents
tbg - a new file format for genomic data
2021
AbstractMotivationThe question of determining whether a Single-Nucleotide Polymorphism (SNP) or a variant in general leads to a change in the amino acid sequence of a protein coding gene is often a laborious and time-consuming challenge. Here, we introduce the tbg file format for storing genomic data and tbg-tools, a user-friendly toolbox for the faster analysis of SNPs. The file format stores information for each nucleotide in each gene, allowing to predict which change in the amino acid sequence will be caused by a variant in the nucleotide sequence. Our new tool therefore has the potential to make biological sense of the unprecedented amount of genome-wide genetic variation that research…
Total Variation Regularization in Digital Breast Tomosynthesis
2013
We developed an iterative algebraic algorithm for the reconstruction of 3D volumes from limited-angle breast projection images. Algebraic reconstruction is accelerated using the graphics processing unit. We varied a total variation (TV)-norm parameter in order to verify the influence of TV regularization on the representation of small structures in the reconstructions. The Barzilai-Borwein algorithm is used to solve the inverse reconstruction problem. The quality of our reconstructions was evaluated with the Quart Mam/Digi Phantom, which features so-called Landolt ring structures to verify perceptibility limits. The evaluation of the reconstructions was done with an automatic LR detection a…
Design of composite measure schemes for comparative severity assessment in animal-based neuroscience research: A case study focussed on rat epilepsy …
2020
PLOS ONE 15(5), e0230141 (2020). doi:10.1371/journal.pone.0230141
Concordance Analysis
2011
Background In this article, we describe qualitative and quantitative methods for assessing the degree of agreement (concordance) between two measuring or rating techniques. An assessment of concordance is particularly important when a new measuring technique is introduced.
Identificación de Urgencias por Asma y Enfermedad Pulmonar Obstructiva Crónica en el Servicio de Urgencias de un Hospital. Estudio de Concordancia
1999
ResumenObjetivoAnalizar la concordancia de los resultados obtenidos en la identificación de los casos de asma y enfermedad pulmonar obstructiva crónica (EPOC) diagnosticados en las historias clínicas de urgencias del Hospital Clínico Universitario de Valencia.MétodosEn el contexto de un estudio más amplio sobre la relación entre urgencias por asma y EPOC y determinados factores de riesgo ambientales, se revisaron todas las historias clínicas de urgencias médicas de mayores de 14 años del Hospital Clínico Universitario de Valencia correspondientes a los años 1993 y 1994. Los observadores fueron dos diplomados en enfermería, previamente entrenados en el procedimiento de identificación de caso…
What is the frequency of anatomical variations and pathological findings in maxillary sinuses among patients subjected to maxillofacial cone beam com…
2016
Background When considering dental implant rehabilitation in atrophic posterior sectors, the maxillary sinuses must be evaluated in detail. Knowledge of the anatomical variations and of the potential lesions found in these structures conditions the outcome of sinus lift procedures and therefore of the dental implants. A systematic review is made to determine the frequency of anatomical variations and pathological findings in maxillary sinuses among patients subjected to cone beam computed tomography (CBCT). Material and Methods A PubMed (MEDLINE) literature search was made of articles published up until 20 December 2015. The systematic review was conducted based on the Preferred Reporting I…
Interobserver and intraobserver variability in the radiological assessment of sialolithiasis using cone beam computed tomography
2021
Background Data regarding the inter- and intraobserver variability in the radiological assessment of sialolithiasis using cone beam computed tomography are missing in the current literature. This study assessed the inter- and intraobserver variability in the radiological assessment of sialolithiasis using cone beam computed tomography (CBCT). Material and Methods In 107 patients, 130 salivary glands (65 parotid and 65 submandibular) with clinical signs of obstruction were assessed by four independent observers; 2 residents OMFS and 2 experienced OMFS. The observers analyzed the CBCT images and determined the absence or presence of one or more salivary stones in the affected gland. This proc…
Conservation genetics of highly isolated populations of the xerothermic beetleCrioceris quatuordecimpunctata(Chrysomelidae)
2012
Xerothermic species are rare and threatened in central and eastern Europe. In light of the continuing loss of steppe-like habitats due to anthropogenic fragmentation and degradation, the evaluation of genetic variation in populations inhabiting them is of immediate importance if appropriate conservation measures are to be undertaken. Here we report on the genetic diversity of the rare leaf beetle Crioceris quatuordecimpunctata, whose populations in central and eastern Europe inhabit highly geographically isolated areas. All of the studied populations (in Poland, Ukraine, and Slovakia) were differentiated at the mitochondrial marker COI. However, with respect to the nuclear marker ITS1, Poli…
Conservation genetics of an endemic from the Mediterranean Basin: high genetic differentiation but no genetic diversity loss from the last population…
2013
The Mediterranean Basin is a biodiversity hotspot, housing > 11.000 narrowly endemic plant species, many of which are declining due to mass tourism and agricultural intensification. To investigate the genetic resource impacts of ongoing habitat loss and degradation, we characterized the genetic variation in the last known populations of Leopoldia gussonei, a self-compatible endangered Sicilian Grape Hyacinth numbering less than 3,000 remaining individuals, using AFLP. Results demonstrated significant genome-wide genetic differentiation among all extant populations (I broken vertical bar(ST) = 0.05-0.56), and genetic clustering according to geographic location. Gene diversity was fairly c…
Patterns of genetic and phenotypic variation in Iris haynei and I. atrofusca (Iris sect. Oncocyclus = the royal irises) along an ecogeographical grad…
2002
Iris haynei and I. atrofusca are two closely related narrow endemics distributed vicariously along an ecogeographical north-south gradient in Israel and the West Bank. To obtain baseline information of the taxonomic status, conservation and population history of these taxa, we investigated patterns of phenotypic variation and the partitioning of genetic variation within and among populations using dominant random amplified polymorphic DNA (RAPD) markers. Multivariate (principal components analysis) and taxonomic distance analyses based on morphometric traits from eight populations revealed no unambiguous separation into two distinct groups. Results of genetic analyses for nine populations d…