Search results for " Variation"
showing 10 items of 1712 documents
Interaction risk with proton pump inhibitors in general practice: significant disagreement between different drug-related information sources.
2006
Aims To compare information on drug–drug interactions (DDIs) reported on two standard drug-related information sources (Summary of Product Characteristics and Drugdex system by Micromedex), by assessing the prevalence and predictors of potential DDI with proton pump inhibitors (PPIs) in general practice. Methods From the ‘Caserta-1’ Local Health-Service database, 156 general practitioners (GPs) were recruited. From more than 180 000 individuals registered on their lists, we selected patients receiving co-prescription of PPI and medications at interaction risk, according to the Italian Summary of Product Characteristics (SPC) of PPI and Drugdex information, during the year 2003. Thereafter, …
Hepatocytes--the choice to investigate drug metabolism and toxicity in man: in vitro variability as a reflection of in vivo.
2007
The pharmaceutical industry is committed to marketing safer drugs with fewer side effects, predictable pharmacokinetic properties and quantifiable drug-drug interactions. Drug metabolism is a major determinant of drug clearance and interindividual pharmacokinetic differences, and an indirect determinant of the clinical efficacy and toxicity of drugs. Progressive advances in the knowledge of metabolic routes and enzymes responsible for drug biotransformation have contributed to understanding the great metabolic variations existing in human beings. Phenotypic as well genotypic differences in the expression of the enzymes involved in drug metabolism are the main causes of this variability. How…
Data from: Sequential infection can decrease virulence in a fish-bacterium-fluke interaction: implications for aquaculture disease management
2019
Hosts are typically infected with multiple strains or genotypes of one or several parasite species. These infections can take place simultaneously, but also at different times, i.e. sequentially, when one of the parasites establishes first. Sequential parasite dynamics are common in nature, but also in intensive farming units such as aquaculture. However, knowledge of effects of previous exposures on virulence of current infections in intensive farming is very limited. This is critical as consecutive epidemics and infection history of a host could underlie failures in management practises and medical intervention of diseases. Here, we explored effects of timing of multiple infection on viru…
In-Depth Analysis of Pricing Problem Relaxations for the Capacitated Arc-Routing Problem
2015
Recently, Bode and Irnich [Bode C, Irnich S (2012) Cut-first branch-and-price-second for the capacitated arc-routing problem. Oper. Res. 60(5):1167–1182] presented a cut-first branch-and-price-second algorithm for solving the capacitated arc-routing problem (CARP). The fundamental difference to other approaches for exactly solving the CARP is that the entire algorithm works directly on the typically sparse underlying graph representing the street network. This enables the use of highly efficient dynamic programming-based pricing algorithms to solve the column-generation subproblem also known as the pricing problem. The contribution of this paper is the in-depth analysis of the CARP pricing…
Influence of the Madden-Julian Oscillation on Southern African summer rainfall
2007
Rain-causing mechanisms over Southern Africa (south of 15˚S) involve both tropical and temperate dynamics. Most studies focused on the synoptical timescale, while the intraseasonal (20-120 days) variability has more been neglected to date. This study aims at determining whether the dominant mode of intraseasonal variability in the Tropics, namely the Madden-Julian Oscillation (MJO), has a significant impact on Southern African rainfall and associated atmospheric dynamics. The examination of outgoing longwave radiation (OLR) over Southern Africa shows indeed significant intraseasonal fluctuations at the 30-60 day timescale, i.e. in the pe- riods that are typically reminiscent of the MJO. In ord…
DIURNAL RAINFALL VARIATION IN MALAYA1
1968
ABSTRACT In low latitudes, where seasonal differences of climate are small and usually limited to factors such as winds and precipitation, the weather is largely controlled by diurnal processes. The diurnal variation of rainfall is the most important result of these processes and it is a characteristic part of the climate. In Malaya, diurnal rainfall regimes show seasonal variations, which are closely related to the system of the southeast Asian monsoons. The seasonal variations differ according to location, and three regional types can be recognized, which are found, respectively, at the west coast, the east coast, and at inland stations. Singapore, because of its extreme location at the s…
Increasing growth temperature alters the within-host competition of viral strains and influences virus genetic variation
2020
AbstractThe emergence of viral diseases in plant crops hamper the sustainability of food production, and this may be boosted by global warming. Concurrently, mixed viral infections are becoming common in plants, of which epidemiology are unpredictable due to within-host virus-virus interactions. However, the extent in which the combined effect of variations in the abiotic components of the plant ecological niche (e.g., temperature) and the prevalence of mixed infections (i.e., within-host interactions among viruses) affect the evolutionary dynamics of viral populations is not well understood. Here, we explore the interplay between ecological and evolutionary factors during viral infections,…
Genetic variability of the blue and red shrimp Aristeus antennatus in the Western Mediterranean Sea inferred by DNA microsatellite loci
2011
Genetic variation at eight microsatellite loci was studied in nine populations of the blue and red shrimp Aristeus antennatus to investigate whether distinct stocks are present in the Western Mediterranean Sea. A high level of gene flow and no evidence of genetic partitioning were discovered. No significant variation was found (FST = 0.00673, P-value = 0.067) even when shrimps from exploited and those from deep-water unexploited grounds were compared. No evidence of reduction or expansion of population size in the recent past was found, as indicated by the bottleneck and interlocus g-tests. Our results are consistent with previous studies using mitochondrial gene methods and allozymes, indi…
Diel vertical movements of zooplankton in lake La Cruz (Cuenca, Spain)
2000
The study of diel vertical movements of zooplankton in a small meromictic karstic lake (lake La Cruz), presenting highly stratified waters, was performed using two different methodologies: (i) samples were taken along the vertical profile and were compared at different hours in a diel cycle; (ii) some plankton traps were located at different depths, covering different periods of time, to catch organisms going upwards and downwards. The main subject of this study has been the vertical movements affecting rotifers since they were dominant in the zooplankton of this lake, but we have also included the results obtained for other zooplankton groups. The results indicate an almost general movemen…
Decomposing changes in the conditional variance of GDP over time
2017
A well established fact in the growth empirics literature is the increasing (unconditional) variation in output per capita across countries. We propose a nonparametric decomposition of the conditional variation of output per capita across countries to capture different channels over which the variation might be increasing. We find that OECD countries have experienced diminishing conditional variation while other regions have experienced increasing conditional variation. Our decomposition suggests that most of these changes in the conditional variance of output are due to unobserved factors not accounted for by the traditional growth determinants. In addition to this we show that these facto…