Search results for " Vascular"
showing 10 items of 945 documents
Caracterización del efecto de los medicamentos biológicos sobre las fases iniciales de la formación de un trombo en pacientes con psoriasis
2022
La psoriasis es una enfermedad inflamatoria crónica inmunomediada, considerada una de las pocas enfermedades no transmisibles que la OMS ha identificado como un importante problema de salud. En los últimos años se ha evidenciado la existencia de una relación entre la psoriasis moderada-grave y el riesgo aumentado de sufrir enfermedades cardiovasculares (CV), considerándola en la mayoría de estudios como un factor de riesgo CV independiente de los factores tradicionales. Los mecanismos subyacentes detrás del aumento del riesgo CV no están claros, pero la alta prevalencia de aterosclerosis en estos pacientes, son consistentes con una condición inflamatoria que podría ser el inicio del puente …
NG-monomethyl-L-arginine and NG-nitro-L-arginine inhibit endothelium-dependent relaxations in human isolated omental arteries.
1991
Abstract The L-arginine analogues NG-monomethyl-l-arginine (l-NMMA, 10−4 m) and NG-nitro-L-arginine methyl ester (l-NAME, 10−4 m), which specifically inhibit the synthesis of nitric oxide from l-arginine, significantly reduced acetylcholine-induced endothelium-dependent relaxations in rings of human omental arteries. The inhibitory potency of l-NMMA and l-NAME was similar. Addition of l-NMMA or l-NAME to the organ bath did not induce any significant changes in the resting tension of the tissues. The effects of l-NMMA were reversed by l-arginine (3 × 10−4 m). The l-NMMA enantiomer, d-NMMA (10−4 m), did not influence either the basal tone of the preparation or the relaxing effects of acet…
Pathophysiology of vascular dementia.
2009
The concept of Vascular Dementia (VaD) has been recognized for over a century, but its definition and diagnostic criteria remain unclear.Conventional definitions identify the patients too late, miss subjects with cognitive impairment short of dementia, and emphasize consequences rather than causes, the true bases for treatment and prevention. We should throw out current diagnostic categories and describe cognitive impairment clinically and according to commonly agreed instruments that document the demographic data in a standardized manner and undertake a systematic effort to identify the underlying aetiology in each case.Increased effort should be targeted towards the concept of and criteri…
Significado pronóstico de la expresión del factor de crecimiento endotelial vascular (VEGF) y de genes implicados en las vías de señalización del VEG…
2022
El estudio de las características de la leucemia aguda mieloblástica (LMA) al diagnóstico es fundamental porque clasifica a los pacientes en grupos pronósticos para adaptar el tratamiento al riesgo de recaída y reducir la toxicidad. Sin embargo, existe un grupo de pacientes en los que no se detectan alteraciones citogenéticas o moleculares y cuya evolución es muy heterogénea. Diversos estudios han demostrado un aumento de la angiogénesis en la médula ósea de los pacientes con LMA así como de citoquinas proangiogénicas como el factor de crecimiento endotelial vascular (VEGF). Las células leucémicas inducen la angiogénesis a través del VEGF, que regula la proliferación, supervivencia, angiogé…
Mediterranean diet impact on cardiovascular diseases: a narrative review
2017
Cardiovascular disease (CVD) accounts for more than 17 million deaths per year worldwide. It has been estimated that the influence of lifestyle on CVD mortality amounts to 13.7% for smoking, 13.2% for poor diet, and 12% for inactive lifestyle. These results deeply impact both the healthy status of individuals and their skills in working. The impact of CVD on productivity loss accounts for the 24% in total costs for CVD management. Mediterranean diet (MedD) can positively impact on natural history of CVD. It is characterized by a relatively high consumption of inexpensive and genuine food such as cereals, vegetables, legumes, nuts, fish, fresh fruits, and olive oil as the principal source of…
The significance of low-density lipoproteins size in vascular diseases
2006
Low density lipoproteins (LDL) comprise in humans two different main fractions: large, buoyant and small, dense particles. Small, dense LDL particles correlate negatively with plasma HDL levels and positively with plasma triglyceride concentrations and are associated with the metabolic syndrome and increased risk for cardiovascular disease. LDL size seems to be an important predictor of cardiovascular events and progression of coronary heart disease (CHD). In addition, several studies have suggested that therapeutic modulation of specific LDL subclasses may be of great benefit in reducing the atherosclerotic risk. Therefore, LDL size measurement may be of potential value in the clinical ass…
Aplicación de la Termografía Infrarroja en Pediatría: Análisis de las alteraciones de la microcirculación cutánea
2020
Desde los inicios de la medicina, se conoce la relación entre enfermedad y las variaciones de temperatura corporal, lo que ha llevado al estudio y desarrollo de técnicas de termometría, que permitiesen cuantificar dichos cambios de temperatura. Entre ellas, destaca la Termografía Infrarroja, que es una técnica de imagen inocua, ya que se basa en captar la emisión de radiación del infrarrojo que emite el cuerpo, es rápida de realizar y accesible, pues se puede realizar cerca del paciente, sin necesidad de desplazamientos ni sedación. Todas estas características hacen que sea una técnica recomendable para utilizar en la población pediátrica que, por su corta edad, es más vulnerable a las radi…
A Novel Bio-Inspired Approach for High-Performance Management in Service-Oriented Networks
2021
Service-continuity in distributed computing can be enhanced by designing self-organized systems, with a non-fixed structure, able to modify their structure and organization, as well as adaptively react to internal and external environment changes. In this paper, an architecture exploiting a bio-inspired management approach, i.e., the functioning of cell metabolism, for specialized computing environments in Service-Oriented Networks (SONs) is proposed. Similar to the processes acting in metabolic networks, the nodes communicate to each other by means of stimulation or suppression chains giving rise to emergent behaviors to defend against foreign invaders, attacks, and malfunctioning. The mai…
Synthesis and biological evaluation of sphingosine kinase 2 inhibitors with anti-inflammatory activity.
2019
The synthesis of inhibitors of SphK2 with novel structural scaffolds is reported. These compounds were designed from a molecular modeling study, in which the molecular interactions stabilizing the different complexes were taken into account. Particularly interesting is that 7‐bromo‐2‐(2‐phenylethyl)‐2,3,4,5‐tetrahydro‐1,4‐epoxynaphtho[1,2‐b]azepine, which is a selective inhibitor of SphK2, does not exert any cytotoxic effects and has a potent anti‐inflammatory effect. It was found to inhibit mononuclear cell adhesion to the dysfunctional endothelium with minimal impact on neutrophil–endothelial cell interactions. The information obtained from our theoretical and experimental study can be us…
Comparison of the contractile effects of endothelin-1 and sarafotoxin S6b in goat isolated cerebral arteries
1992
1. The effects of endothelium-derived endothelin-1 and snake venom-derived sarafotoxin S6b, peptides with striking structural and functional similarities, were examined and compared in isolated middle cerebral arteries of goats. 2. Endothelin-1 and sarafotoxin S6b contracted cerebral arteries in a concentration-dependent manner. The potency of endothelin-1 (EC50 = 4.9 (3.9-6.2) x 10(-10) M) was about ten times higher than that of sarafotoxin S6b (EC50 = 5.5 (4.4-6.9) x 10(-9) M). The tension returned to basal values after repeated washings and contraction with endothelin-1 could be reproduced. Endothelin-1 and sarafotoxin S6b induced further contraction in arteries precontracted with prosta…