Search results for " activity"

Synthesis and anti-HIV activity of 2,3-diaryl-1,3-thiazolidin-4-(thi)one derivatives.

2002

Several 2,3-diaryl-1,3-thiazolidine-4-thione derivatives and 2,3-diaryl-1,3-thiazolidin-4-ones bearing a methyl group at C-5 position have been synthesized and tested as anti-HIV agents. The results of the in vitro tests showed that some of them proved to be effective inhibitors of HIV-1 replication.

2-cinnamamido, 2-(3-phenylpropiolamido) and 2-(3-phenylpropanamido)benzamides: synthesis, antiproliferative activity and mechanism of action

2013

Several new 2-cinnamamido, 2-(3-phenylpropiolamido) and 2-(3-phenylpropanamido)benzamides were synthesized by stirring in pyridine the opportune acid chlorides with the appropriate anthranilamide derivatives. Some of the synthesized compounds were evaluated for their in vitro antiproliferative activity against a panel of 5 human cell lines (K562 human chronic myelogenous leukemia cells, MCF-7 breast cancer cells, HTC-116 and HT26 colon cancer cells and NCI H460 non-small cell lung cancer cells).

Synthesis and biological evaluation of some new 2-cinnamidobenzamides as potential antagonist of the HDM2-p53 protein-protein interactions

2008

Television in the bedroom and increased body weight: potential explanations for their relationship among European schoolchildren

2012

Summary Aims: A television in the bedroom is associated with measures of adiposity. We aimed to test if this association is mediated by any of (i) time spent watching television, (ii) sleep duration, (iii) physical activity level or (iv) consumption of soft drinks. Method: Data were from 7234 boys and girls aged 10–12 years in European countries involved in the EuropeaN Energy balance Research to prevent excessive weight Gain among Youth project (Belgium, Greece, Hungary, the Netherlands, Norway, Slovenia and Spain). Waist circumference, height and weight were measured. The presence of a bedroom television, television viewing time, sleep duration, physical activity time and soft drink consu…

Culture Conditions Affect Antioxidant Production, Metabolism and Related Biomarkers of the Microalgae Phaeodactylum tricornutum

2022

Phaeodactylum tricornutum (Bacillariophyta) is a worldwide-distributed diatom with the ability to adapt and survive in different environmental habitats and nutrient-limited conditions. In this research, we investigated the growth performance, the total lipids productivity, the major categories of fatty acids, and the antioxidant content in P. tricornutum subjected for 15 days to nitrogen deprivation (N−) compared to standard culture conditions (N+). Furthermore, genes and pathways related to lipid biosynthesis (i.e., glucose-6-phosphate dehydrogenase, acetyl-coenzyme A carboxylase, citrate synthase, and isocitrate dehydrogenase) and photosynthetic activity (i.e., ribulose-1,5-bisphosp…

Dual Careers of Athletes During COVID-19 Lockdown

2021

This study aimed to investigate the student-athletes' capability to face the academic, sport, and social challenges during the coronavirus disease 2019 (COVID-19) lockdown and to disclose novel aspects of dual careers. A 32-item online survey encompassing demographic characteristics, sport and university engagement, support and dual-career benefits, physical activity, sitting time, and the time deemed necessary to recover the previous level of performance was developed. Four hundred sixty-seven student-athletes (males: 57%, females: 43%) from 11 countries, competing in 49 different sports (individual: 63.4%, team: 36.6%) at regional (17.5%), national (43.3%), and international (39.2%) level…

Experimental analysis of the potential validity of Lorenzini’s hypothesis to treat COVID-19 patients

2021

The present research was aimed at testing the potential validity of Lorenzini’s hypothesis against Covid-19, based on the use of far UV-C rays directly on the patient’s ill lungs, so to significantly reduce the virus presence and with it the interstitial pneumonia, the cause of most deaths. Not having had the chance to experiment directly on the SARS-CoV-2, we shifted to a plant virus called TSWV, which has some common characteristics with SARS-CoV-2, so making our tests significant. The virus was suitably utilized so to affect an opportune range of pepper plants, after a treatment with 2 UV-C lamps, of which just one spreading far UV-C rays. Results showed that the effect of a quick exposi…

COVID-19 Confinement and Health Risk Behaviors in Spain

2021

The World Health Organization (WHO) has declared a world pandemic due to COVID-19. In response, most affected countries have enacted measures involving compulsory confinement and restrictions on free movement, which likely influence citizens' lifestyles. This study investigates changes in health risk behaviors (HRBs) with duration of confinement. An online cross-sectional survey served to collect data about the Spanish adult population regarding health behaviors during the first 3 weeks of confinement. A large sample of participants (

Paediatric Emergencies During the COVID-19 Pandemic

2021

The state of alarm decreed by the Spanish Government, due to the Coronavirus Disease-19 (COVID-19) pandemic, has demanded the lockdown of children and has conditioned a new organization of the Emergency Departments (ED). A pre-triage station and 2 independent circuits were established: suspected COVID-19 and not suspected COVID-19. The ED visits decreased 84,5% from pre-alarm with no increase in the level of urgencies. During the alarm state, 40.97% of the children were classified as suspected COVID-19. Fever and respiratory symptoms, used as discriminators, generated 2 groups of patients with different characteristics. Although the interruption of sports activities and isolation of childr…

Prevalence and Correlates of Physical activity in a sample of UK adults observing social distancing during the COVID-19 pandemic

2020

ObjectiveTo investigate the levels and correlates of physical activity during COVID-19 social distancing in a sample of the UK public.MethodsThis paper presents analyses of data from a cross-sectional study. Levels of physical activity during COVID-19 social distancing were self-reported. Participants also reported on sociodemographic and clinical data. The association between several factors and physical activity was studied using regression models.ResultsNine hundred and eleven adults were included (64.0% were women and 50.4% of the participants were aged 35–64 years). 75.0% of the participants met the physical activity guidelines during social distancing. Meeting these guidelines during …