Search results for " adenoma"
showing 10 items of 131 documents
Hsp27 and Hsp60 in human submandibular salivary gland: Quantitative patterns in healthy and cancerous tissues with potential implications for differe…
2021
Tumors of the submandibular salivary gland (SMG) are uncommon but sufficiently frequent for the physician to consider them in routine examinations and for the pathologist to be prepared to differentiate them from other tissue abnormalities. However, scarcity of specimens makes training difficult, a situation compounded by the lack of accepted universal diagnostic guidelines. Furthermore, there is little information on the chaperone system (CS) of the gland, despite the increasing evidence of its participation in carcinogenesis as a biomarker for diagnosis and patient follow up, and in the mechanisms by which the tumor cells thrive. We are investigating this aspect of various tumors, and her…
ANP differentiates between primary Submandibular Gland Squamous Cell Carcinoma and Oral Squamous Cell Carcinoma: Preliminary data
2021
The natriuretic peptide system consists of three ligands, Atrial Natriuretic Peptide (ANP), Brain Natriuretic peptide (BNP) and C-type Natriuretic peptide (CNP), and three natriuretic peptide receptors (NPR’s), NPRA, NPRB and NPRC. We investigated the expression levels of NPPA (encoding ANP) and NPR1 (encoding NPRA, the main receptor for ANP) in primary benign (pleomorphic adenoma) and malignant (squamous cell carcinoma, SCC) submandibular salivary gland (SMG) tumors, as well as in primary oral squamous cell carcinoma (OSCC). We found that the NPPA and NPR1 expression levels were significantly different in SMG SCC versus OSCC, exhibiting a significant increase in NPPA and absence of NPR1 ex…
Benign liver lesions 2022: Guideline for clinical practice of Associazione Italiana Studio del Fegato (AISF), Società Italiana di Radiologia Medica e…
2022
Benign liver lesions are increasingly diagnosed in daily clinical practice due to the growing use of imaging techniques for the study of the abdomen in patients who have non-specific symptoms and do not have an increased risk of hepatic malignancy. They include simple or parasitic cysts and solid benign tumors which differ widely in terms of prevalence, clinical relevance, symptoms and natural history and often lead to significant clinical problems relating to diagnosis and clinical management. Following the need to have updated guidelines on the management of benign focal liver lesions, the Scientific Societies mainly involved in their management have promoted the drafting of a new dedicat…
A two miRNA classifier differentiates follicular thyroid carcinomas from follicular thyroid adenomas.
2015
The inherent diagnostic limitations of thyroid fine needle aspiration (FNA), especially in the "indeterminate" category, can be partially overcome by molecular analyses. We aimed at the identification of miRNAs that could be used to improve the discrimination of indeterminate FNAs. miRNA expression profiling was performed for 17 follicular carcinomas (FTCs) and 8 follicular adenomas (FAs). The microarray results underwent cross-comparison using three additional microarray data sets. Candidate miRNAs were validated by qPCR in an independent set of 32 FTCs and 46 FAs. Sixty-eight differentially expressed miRNAs were identified. Thirteen miRNAs could be confirmed by cross comparison. A two-miR…
Transkriptoma analīze akromegālijas pacientiem ar un bez medikamentozās terapijas
2019
Darba mērķis bija veikt somatotrofas hipofīzes adenomas audu transkriptoma analīzi pacientiem, kuri ir vai nav lietojuši medikamentozo terapiju pirms operācijas, analizējot SST/DA analogu izraisītās izmaiņas transkriptomā. Lai to realizētu tika izdalīts totālais RNS no pacientu somatotrofās hipofīzes adenomas audiem un sagatavotas transkriptoma bibliotēkas. Pēc tam iegūtie dati tika analizēti, izmantojot Galaxy platformu un programmu R un R Studio. Pēc datu analīzes tika iegūti 22 statistiski būtiski DEGs un no tiem viens būtiski iesaistīts signālceļš, kā arī intensitātes grafikā tika novērotas divas izteiktas gēnu grupas, kas iedalijās starp pacientiem atkarībā no medikamentozās terapijas.
Hsp60 in embryonic and adult submandibular salivary gland: quantitative distribution patterns in normal tissue and comparison with benign and maligna…
2019
Introduction: Heat Shock Protein 60 (Hsp60) is a member of the chaperoning system that assists protein folding inside mitochondria and plays other roles beyond these organelles. It is implicated in the carcinogenic processes in various types of cancer. In human salivary glands, Hsp60 has not yet been measured or mapped in detail and its role in gland development and functioning is virtually unknown. Consequently, its potential as biomarker for gland diseases, including malignancies cannot be assessed. The S-100 protein, a known marker for schwannomas, has been found also in myoepithelial-cell carcinomas of the salivary glands. Here, we present our initial findings on the anatomic-histologic…
Centrālās nervu sistēmas ietekme uz adenohipofīzes adenomu attīstību
2015
Adenohipofīzes adenomas ir labdabīgi intrakraniāli endokrīnie audzēji ar potenciāli augstu prevalenci populācijā. To rašanās rezultātā pacientiem var attīstīties plaša spektra veselības problēmas. Bakalaura darbā veikta adenohipofīzes adenomu šūnu izpēte, analizējot to proliferāciju un saistību ar CNS. Darba gaitā tika konstatētas dažādas CNS cilmes šūnām raksturīgās īpašības adenomu paraugos.
Long-term evolution of hepatocellular adenomas at MRI follow-up
2021
Background Hepatocellular adenomas (HCAs) are rare benign liver tumors. Guidelines recommend continued surveillance of patients diagnosed with HCAs, but these guidelines are mainly based on small studies or expert opinion. Purpose To analyze the long-term evolution of HCAs, including solitary and multiple lesions, and to identify predictive features of progression with MRI. Materials and Methods In a retrospective study, patients diagnosed with pathologically proven solitary or multiple HCAs between January 2004 and December 2015 were included; β-catenin-mutated HCAs and HCAs with foci of malignancy were considered to be at risk for progression. MRI examinations were analyzed, and tumor evo…
Radiogrāfera kompetence abdominālajā datortomogrāfijā virsnieru adenomas gadījumā
2016
Darbs “Radiogrāfera kompetence abdominālajā datortomogrāfijā virsnieru adenomas gadījumā” sniedz izpratni par radiogrāfera zināšanu un prasmju ietekmi uz izmeklējuma gaitu un rezultātu. Analizējot literatūru, tika vērsta uzmanība uz datortomogrāfijas izmeklējumu ietekmējošajiem faktoriem, kuri ir būtiski rdiogrāfera darbā. Darbā aprakstīta virsnieru normālā anatomija, fizioloģija, kā arī virsnieru adenomu īpatnības un datortomogrāfijas metodes iespējas to diagnostikā. Pētījumā tiek secināts, ka radiogrāferi, kuri strādā konkrētajā veselības aprūpes iestādē, ietekmē izmeklējuma gaitu, pielāgojot datortomogrāfijas protokolu konkrētajam pacientam, jo ne visiem pacientiem izmeklējums tiek veikt…
Malignancy course of pituitary adenoma in MEN1 syndrome: Clinical-Neuroradiological signs
2020
Pituitary carcinomas (PCa) are extremely rare, indistinguishable from pituitary adenomas on histopathological grounds and have a poor prognosis. Most PCa start as PRL or ACTH secreting tumors in males, with relapsing invasive behaviour, refractoriness to medical and radiotherapy and increasing hormonal levels. The presence of distant metastases is still required for the diagnosis of PCa. The association with genetic endocrine diseases must be taken into account, since it adds further risk of evolution towards malignancy. Intradural spinal metastases have also been reported, so a complete craniospinal MR evaluation is recommended, when clinically indicated. We report a case of PCa, associate…