Search results for " adolescent"
showing 10 items of 621 documents
Anabolic steroid abuse and dependence: psychiatric effects in adolescents and young adults
2009
Safety profile of the interleukin-1 inhibitors anakinra and canakinumab in real life clinical practice: a nationwide multicenter retrospective observ…
2018
A few studies have reported the safety profile of interleukin (IL)-1 blockers from real life. The aim of this study is to describe anakinra (ANA) and canakinumab (CAN) safety profile in children and adults, based on data from a real-life setting. Demographic, clinical, and therapeutic data from patients treated with ANA and CAN were retrospectively collected and analyzed. Four hundred and seventy five patients were enrolled; ANA and CAN were prescribed in 421 and 105 treatment courses, respectively. During a mean follow-up of 24.39 ± 27.04 months, 89 adverse events (AE) were recorded; 13 (14.61%) were classified as serious AE (sAE). The overall estimated rate of AE and sAE was 8.4 per 100 p…
Missense mutations in the fas gene resulting in autoimmune lymphoproliferative syndrome: A molecular and immunological analysis
1997
AbstractProgrammed cell death (or apoptosis) is a physiological process essential to the normal development and homeostatic maintenance of the immune system. The Fas/Apo-1 receptor plays a crucial role in the regulation of apoptosis, as demonstrated by lymphoproliferation in MRL-lpr/lpr mice and by the recently described autoimmune lymphoproliferative syndrome (ALPS) in humans, both of which are due to mutations in the Fas gene. We describe a novel family with ALPS in which three affected siblings carry two distinct missense mutations on both the Fas gene alleles and show lack of Fas-induced apoptosis. The children share common clinical features including splenomegaly and lymphadenopathy, b…
El aprendizaje a distancia y los adolescentes en el momento de la pandemia: espacialidad e interacciones
2021
Il capitolo esplora alcune modalità attraverso cui gli studenti adolescenti hanno vissuto e stanno vivendo lunghi periodi di apprendimento a distanza a causa delle misure anti-pandemia. Lo studio qui proposto si basa su una ricerca che ho condotto nel 2021 con un approccio geografico e semiotico in una scuola secondaria di Palermo. I destinatari sono sette studenti dello stesso anno scolastico, di età compresa tra i 16 e i 17 anni, a cui è stato chiesto di elaborare un breve testo che descrive come avevano affrontato in tutto o in parte i periodi di formazione a distanza. El objetivo de este trabajo es explorar algunas de las formas en que los estudiantes adolescentes han vivido y están exp…
TP53 codon 72 polymorphism and cervical cancer
2009
Background Cervical cancer is caused primarily by human papillomaviruses (HPV). The polymorphism rs1042522 at codon 72 of the TP53 tumour-suppressor gene has been investigated as a genetic cofactor. More than 80 studies were done between 1998 and 2006, after it was initially reported that women who are homozygous for the arginine allele had a risk for cervical cancer seven times higher than women who were heterozygous for the allele. However, results have been inconsistent. Here we analyse pooled data from 49 studies to determine whether there is an association between TP53 codon 72 polymorphism and cervical cancer.Methods Individual data on 7946 cases and 7888 controls from 49 different st…
Risk factors for being a victim of online grooming in adolescents
2020
The risk of child grooming has spread exponentially with the massive access of adolescents to social networks and the internet. The aim of the study was to examine the personal factors (body self-esteem and disinhibition) and erotic-sexual factors (sexual initiation strategies and erotic-pornographic sexting) that predict grooming. METHOD: The sample was comprised of 1,200 adolescents aged between 12 and 16 years (M = 14.54, SD = 1.17; 50.83% girls). A cross-sectional design with self-report data was used and structural equation modeling (SEM) with mediation analysis was performed. RESULTS: The results indicated two paths explaining child grooming: 1) physical attractiveness and disinhibiti…
Jumtukaay. Ressources de formation pour un centre du Jour
2022
Ce volume compile le matériel pédagogique créé par l'équipe du projet Chaire Unesco - 2021 de l'Universitat de València, pour être utilisé au Centre de Jour de Bambey (Sénégal), dans les di érents programmes qui y sont développés. Este libro es el resultado del Proyecto Càtedra, “Elaboración de materiales Pedagógicos para el Centro de Día de Bambey (Senegal)@ y contiene recursos educativos diversos que trabajan el tema empoderamiento de la mujer, migraciones, desarrollo evolutivo-afectivo del niño 0-6 años, informática para adolescentes, Juegos y actividades de Cooperación, Juegos predeportivos, Actividades para rehabilitación de deficiencia auditiva y conocimientos útiles para migrantes. T…
Aperos. Recursos de formación para educadores
2022
Este libro es el resultado del Proyecto Càtedra, “Elaboración de materiales Pedagógicos para el Centro de Día de Bambey (Senegal)@ y contiene recursos educativos diversos que trabajan el tema empoderamiento de la mujer, migraciones, desarrollo evolutivo-afectivo del niño 0-6 años, informática para adolescentes, Juegos y actividades de Cooperación, Juegos predeportivos, Actividades para rehabilitación de deficiencia auditiva y conocimientos útiles para migrantes. This book is the result of the Càtedra Project, "Elaboration of Pedagogical materials for the Day Centre of Bambey (Senegal)@ and contains diverse educational resources that work on women's empowerment, migrations, evolutionary-affe…
When Adolescents with High Self-Concept Lose their Engagement in School // Cuando se pierde la motivación escolar de los adolescentes con mejor autoc…
2015
Engagement in school and self-concept are two main constructs to explain the school adjustment. To understand how engagement might change during adolescence, we analyzed early and middle adolescents’ engagement in school (cognitive, affective, behavioural, and personal agency) as a function of their level of self-concept. Participants were 685 adolescents, 296 males (43.2%) and 389 females between 11-17 years old. Among early adolescents, students with high self-concept always reported more cognitive, affective, behavioural, and personal agency engagement than students with low self-concept. However, among middle adolescents, students with high self-concept reported only higher affective an…
“The Linosa Study”: Epidemiological and heritability data of the metabolic syndrome in a Caucasian genetic isolate
2009
Abstract Background and aims Growing evidence suggests that the metabolic syndrome (MetS) has both a genetic and environmental basis. To evaluate the possibility of a further genetic analysis, we estimated prevalence rates and heritabilities for the MetS and its individual traits in the adult population of Linosa, a small and isolated Italian Island in the southern-central part of the Mediterranean Sea. Methods and results The Linosa Study (LiS) group consisted of 293 Caucasian native subjects from 51 families (123 parents; 170 offsprings). The MetS was defined according to NCEP/ATP III criteria and the following prevalence rates were calculated: hyperglycaemia 20.3%; central obesity 34.9%;…