Search results for " aging"

Changes in tear film metrics and ocular signs induced by different types of refractive correction in an aging population

2018

La integridad de la superficie ocular, en otras palabras, su capacidad para responder adecuadamente a los desafíos ambientales, depende de la integración adecuada de la información desde la superficie ocular, la transmisión de la señal creada hacia el cerebro y la generación de una respuesta, que modulará la función secretora así como la inmunidad local de la superficie ocular. Es fácilmente comprensible que cualquier alteración de uno de los tres pasos de este ciclo cerrado pueda desencadenar una respuesta inapropiada y desequilibrar aún más los mecanismos compensatorios que tienen lugar en la superficie ocular. La unidad funcional de la lágrima se puede definir como un conjunto de estruct…

Associacionisme al procés de jubilació del professorat de la UV: perfil psico-social

2012

La comprensió dels efectes de la transició a la jubilació per a la salut i el benestar psicològic s'ha convertit en un camp d'investigació cada cop més reivindicat (Neuman, 2008), tant per la conjuntura polític-econòmica actual, com per les noves característiques i necessitats de la població major (Pérez, 2006). Donades les característiques particulars i la pràctica inexistència de literatura, l'estudi del col'lectiu dels professors universitaris cobra especial abast en aquesta situació. Així doncs, el present treball té com a objectiu avaluar la satisfacció amb la jubilació i el benestar, de forma extensa i detallada, d'una mostra de 22 professors universitaris jubilats de la Universitat d…

SENILE ANOREXIA IN ACUTE WARD AND REHABILITATION SETTINGS

2008

AORTIC STIFFNESS IS INCREASED IN NORMOTENSIVE PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS Abstracts from the 17th National Congress of the Italian Soc…

2019

Introduction: Patients with systemic lupus erythematosus (SLE) have an increased risk of developing cardiovascular (CV) events. A marker of early vascular aging (EVA) is aortic pulse wave velocity (aPWV) which is a measure of arterial stiffness. Aim: To evaluate aPWV and the prevalence of EVA in a group of normotensive patients with SLE and to compare these values with those obtained in age- and gender-matched control subjects. Method: Aortic PWV was measured by a validated oscillometric device (Arteriograph). EVA was identified when the age-adjusted z-score of aPWV exceeded ? 1.96 (EVA1). The aPWV z-score was calculated using the ratio ‘‘Observed PWV–Predicted PWV/SD Predicted’’ and we obt…

The effects of water absorption and salt fog exposure on agglomerated cork compressive response

2022

The replacement of synthetic foams with agglomerated cork in sandwich composites can meet the increasing environmental concerns. Its peculiar morphology and chemical composition lead to outstanding dimensional recovery that endorsed a broad investigation of its compressive behavior. The knowledge of neat material response is fundamental to obtain a reliable design dataset, but it is necessary to consider all the environmental factors (water, moisture and sunlight) that significantly modify material mechanical properties. In view of this, the present work investigates the effect of distilled and seawater absorption and salt fog exposure on the compressive behavior of two agglomerated corks w…

FREE RADICAL THEORY OF FRAILTY: MOLECULAR MECHANISMS OF FRAILTY RESULTING FROM OXIDATIVE STRESS

2018

The free radical theory of ageing provided an intellectual framework for many laboratories working on ageing. However, experimental and clinical evidence showing that high doses of antioxidants did not have an effect on ageing or on age-associated diseases, cast doubts on the validity of this theory. Data from our own laboratory showed that oxidative stress does not correlate with age, especially in the geriatric population, but rather with the frailty state. This has led us to postulate the free radical theory of frailty in which frailty is associated with oxidative stress, but age itself is not. Superoxide dismutase deficient mice are more frail than controls. But more importantly, we obs…

3D in Suspension versus 2D in Adhesion: molecular profiles in stemness and mesenchymal differentiation of Spheroids from Adipose-derived Stem Cells

2021

Purpose: Adipose stem cells (ASCs) represent a reliable source of stem cells with a widely demonstrated potential in regenerative medicine and tissue engineering applications. New recent insights suggest that three-dimensional (3D) models may closely mimic the native tissue properties; spheroids from adipose derived stem cells (S-ASCs) exhibit enhanced regenerative abilities compared with those of 2D models. Stem cell therapy success is determined by “cell-quality”; for this reason, microRNA profiles, the involvement of stress signals and cellular aging need to be further investigated. Material and Methods: Adipose tissue was collected from healthy individuals, 44 females and 17 males, afte…

A Successful Aging Model Based on Personal Resources, Self-Care, and Life Satisfaction

2021

The most internationally studied models of successful aging defend that there are several pillars for a good aging: absence of disease, good cognitive and physical function, a high commitment and social activity, social capital, personal resources, life satisfaction, and spirituality. This study examines the relationships between personal resources, perceived social support, hope, spirituality, self-care and subjective well-being variables, as bases for a successful aging. One thousand and sixteen community-dwelling Spanish adults, aged 55-92 years, participated in the study. Information on variables assessed was collected using self-reported questionnaires. Confirmatory Factor Analyses and…

B cell immunosenescence: different features of naive and memory B cells in elderly.

2011

Elderly people show a reduced protection against new infections and a decreased response to vaccines as a consequence of impairment of both cellular and humoral immunity. In this paper we have studied memory/naive B cells in the elderly, evaluating surface immunoglobulin expression, production of the pro- and anti-inflammatory cytokines, tumor necrosis factor (TNF)-α and interleukin (IL)-10, and presence of somatic hypermutation, focusing on the IgG(+)IgD(-)CD27(-) double negative (DN) B cells that are expanded in the elderly. Our results show that naive B cells from young donors need a sufficiently strong stimulus to be activated "in vitro", while naive B cells from old subjects are able t…

The role of adolescent lifestyle habits in biological aging: A prospective twin study

2022

Adolescence is a stage of fast growth and development. Exposures during puberty can have long-term effects on health in later life. This study aims to investigate the role of adolescent lifestyle in biological aging.The study participants originated from the longitudinal FinnTwin12 study (n = 5114). Adolescent lifestyle-related factors, including body mass index (BMI), leisure-time physical activity, smoking, and alcohol use, were based on self-reports and measured at ages 12, 14, and 17 years. For a subsample, blood-based DNA methylation (DNAm) was used to assess biological aging with six epigenetic aging measures in young adulthood (21-25 years, n = 824). A latent class analysis was condu…