Search results for " alcohol"
showing 10 items of 578 documents
Novel σ1 antagonists designed for tumor therapy: Structure – activity relationships of aminoethyl substituted cyclohexanes
2021
Abstract Depending on the substitution pattern and stereochemistry, 1,3-dioxanes 1 with an aminoethyl moiety in 4-position represent potent σ1 receptor antagonists. In order to increase the stability, a cyclohexane ring first replaced the acetalic 1, 3-dioxane ring of 1. A large set of aminoethyl substituted cyclohexane derivatives was prepared in a six-step synthesis. All enantiomers and diastereomers were separated by chiral HPLC at the stage of the primary alcohol 7, and their absolute configuration was determined by CD spectroscopy. Neither the relative nor the absolute configuration had a large impact on the σ1 affinity. The highest σ1 affinity was found for cis-configured benzylamines…
Impact of structural features of odorant molecules on their retention/release behaviours in dairy and pectin gels
2014
International audience; Reducing of fat content in food requires a reformulation that may cause a different perception of aroma. Maintaining an adequate level of acceptability of these reformulated products for consumers requires a better understanding of the mechanisms that control the retention of odorant molecules in food matrices. Although pectins are commonly employed as thickeners, their effect on the retention of odorant molecules in nonhomogeneous products has been examined more frequently than their effect on the retention of odorant molecules in simple gels models.The purpose of this study was to explore and compare the respective effects of pectin in simple model systems. The rel…
Determination of hydroxytyrosol and tyrosol by liquid chromatography for the quality control of cosmetic products based on olive extracts
2014
An analytical method for the simultaneous determination of hydroxytyrosol and tyrosol in different types of olive extract raw materials and cosmetic cream samples has been developed. The determination was performed by liquid chromatography with UV spectrophotometric detection. Different chromatographic parameters, such as mobile phase pH and composition, oven temperature and different sample preparation variables were studied. The best chromatographic separation was obtained under the following conditions: C18 column set at 35°C and isocratic elution of a mixture ethanol: 1% acetic acid solution at pH 5 (5:95, v/v) as mobile phase pumped at 1 mL min(-1). The detection wavelength was set at …
Determination of alternative preservatives in cosmetic products by chromophoric derivatization followed by vortex-assisted liquid-liquid semimicroext…
2016
An analytical method for the simultaneous determination of phenethyl alcohol, methylpropanediol, phenylpropanol, caprylyl glycol, and ethylhexylglycerin, which are used as alternative preservatives in cosmetic products, has been developed. The method is based on liquid chromatography with UV spectrophotometric detection after chromophoric derivatization with benzoyl chloride and vortex-assisted liquid-liquid semimicroextraction. Different chromatographic parameters, derivatization conditions, and sample preparation variables were studied. Under optimized conditions, the limits of detection values for the analytes ranged from 0.02 to 0.06µgmL(-1). The method was validated with good recovery …
Frecuencia del consumo de drogas legales: Diferencias de edad en la adolescencia
2007
El consumo de drogas es especialmente relevante por sus efectos negativos sobre la salud psicofísica y el funcionamiento social de los jóvenes. El objetivo de este estudio fue analizar las diferencias de edad respecto a las frecuencias de consumo de alcohol y tabaco en una muestra de 354 escolares (50.85% varones) de 12 a 18 años (M = 14.66; DT = 1.08) que cumplimentaron el Questionnarie about Consume of Alcohol and Tobacco (TNT). Los resultados muestran que el 82.4% de los adolescentes ha consumido bebidas alcohólicas en alguna ocasión y el 25.6% es consumidor actualmente. Respecto al consumo de tabaco, el 40.4% de estudiantes afirma haber fumado en alguna ocasión, siendo consumidores actu…
Thermal, spectroscopic and crystallographic analysis of mannose-derived linear polyols
2018
The major diastereomer formed in the Barbier-type metal-mediated allylation of D-mannose has previously been shown to adopt a perfectly linear conformation, both in solid state and in solution, resulting in the formation of hydrogen-bonded networks and subsequent aggregation from aqueous solution upon stirring. Here, a comprehensive study of the solid state structure of both the allylated D-mannose and its racemic form has been conducted. The binary melting point diagram of the system was determined by differential scanning calorimetry analysis, and the obtained results, along with structure determination by single crystal X-ray diffraction, confirmed that allylated mannose forms a true rac…
Nuovi derivati della Dopamina nell’Addiction da sostanze d’abuso: studi preclinici su modelli sperimentali murini
Evaluation of the Fermentation Dynamics of Commercial Baker’s Yeast in Presence of Pistachio Powder to Produce Lysine-Enriched Breads
2019
The present work was carried out to evaluate the microbiological, physicochemical, and sensory characteristics of fortified pistachio breads. Pistachio powder (5% w/w) was added to flour or semolina and fermented by a commercial baker’s yeast (Saccharomyces cerevisiae). Pistachio powder did not influence the biological leavening of the doughs. The kinetics of pH and total titratable acidity (TTA) during dough fermentation showed that the leavening process occurred similarly for all trials. The concentration of yeasts increased during fermentation and reached levels of 108 CFU/g after 2 h. Pistachio powder decreased the height and softness of the final breads and increased cell density…
Revista española de drogodependencias
2008
Resumen tomado de la publicación La mejor estrategia para prevenir la expansión del VIH-SIDA es la prevención. Son bien conocidas las medidas de prevención, de las que se han realizado una enorme difusión. La transmisión del VIH-SIDA por inaplicación de las medidas de prevención por personas afectadas de modo deliberado y sin comunicación del estado serológico comporta, según diversas sentencias de nuestros Tribunales, sanciones penales o civiles. No obstante, hay que tener en cuenta las circunstancias de las personas en estado de intoxicación por consumo de drogas y alcohol y el consentimiento de la persona que se expone a la transmisión del virus, puesto que podría dar lugar a exoneración…
Estudio del consumo de alcohol y otras drogas en alumnos/as de los cursos de monitores/as de ocio y tiempo libre
2009
Partimos de la idea de que las drogas alteran nuestras emociones, nuestras capacidades y actitudes y nos preguntamos si los/as alumnos/as que realizan los cursos de monitores/ as de ocio y tiempo libre consumen drogas y cómo es dicho consumo, ya que después, van a trabajar con menores y jóvenes, Para averiguarlo, utilizamos el Test de Identifi cación de los Trastornos Debidos al Consumo de Alcohol (AUDIT), para identifi car a las personas con un patrón de consumo perjudicial o de riesgo de alcohol. Y para conocer el resto de sustancias consumidas utilizaremos La Historia Toxicológica, mencionando para cada sustancia; inicio, frecuencia y tiempo de consumo. Como resultados destacamos que un …