Search results for " antibiotic."
showing 10 items of 142 documents
Data from: Conjugation is necessary for a bacterial plasmid to survive under protozoan predation
2016
Horizontal gene transfer by conjugative plasmids plays a critical role in the evolution of antibiotic resistance. Interactions between bacteria and other organisms can affect the persistence and spread of conjugative plasmids. Here we show that protozoan predation increased the persistence and spread of the antibiotic resistance plasmid RP4 in populations of the opportunist bacterial pathogen Serratia marcescens. A conjugation-defective mutant plasmid was unable to survive under predation, suggesting that conjugative transfer is required for plasmid persistence under the realistic condition of predation. These results indicate that multi-trophic interactions can affect the maintenance of co…
Un ecosistema malalt: la lluita contra la resistència a antibiòtics des d’una perspectiva global
2013
La produccio antropogenica d'antibiotics ha provocat una malaltia dels ecosistemes microbians de dimensio planetaria, la repercussio mes immediata de la qual per a l'home es la intractabilitat de les infeccions. La comprensio del fenomen i les possibilitats d'intervencio requereixen nous metodes conceptuals, analitics i tecnologics.
Macrolides May Prevent Severe Acute Respiratory Syndrome Coronavirus 2 Entry into Cells: A Quantitative Structure Activity Relationship Study and Exp…
2021
The global pandemic caused by the emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is threatening the health and economic systems worldwide. Despite the enormous efforts of scientists and clinicians around the world, there is still no drug or vaccine available worldwide for the treatment and prevention of the infection. A rapid strategy for the identification of new treatments is based on repurposing existing clinically approved drugs that show antiviral activity against SARS-CoV-2 infection. In this study, after developing a quantitative structure activity relationship analysis based on molecular topology, several macrolide antibiotics are identified as promising SARS-…
Do we Need a Triple Antibiotic Therapy?
2001
To compare the efficacy and toxicity of triple antibiotic therapy in patients undergoing autologous peripheral blood-stem-cell transplantation (PBSCT) with literature data.
Aspects of excessive antibiotic consumption and environmental influences correlated with the occurrence of resistance to antimicrobial agents
2021
International audience; This article explores the correlation between specific aspects of antibiotic usage, their resistance development, and environmental factors. The indiscriminate use of antibiotics led to environment contamination, selection and spreading of antibiotic-resistant organisms, and alteration of the microbial ecosystems balance. Sociobehavioural environmental factors and changes in the natural environment are major contributors to resistance development. Resistant bacteria strains' isolation in food, water, soil etc. demonstrates the environmental influence on the strains through antibiotics accumulation in the environment. It is difficult to assess the impact of antibiotic…
Clinical and radiographical evaluation of the healing of large periapical lesions using triple antibiotic paste, photo activated disinfection and cal…
2014
Objectives: To evaluate clinically and radio graphically, the healing following nonsurgical treatment of periapical lesions when Photo Activated Disinfection(PAD), triple antibiotic paste and calcium hydroxide was used as root canal disinfectant. Material and Methods: Sixty patients (20 for PAD, 20 for triple antibiotic paste, 20 for calcium hydroxide) with periapical lesions in the maxillary and mandibular anterior region were selected from the outpatient section of the Department of Conservative Dentistry & Endodontics, Govt. Dental College, Kozhikode to participate in this study. The patients were selected with a preoperative score of 4 or 5. There were no significant differences for the…
Antimicrobial therapy in neonatal intensive care unit
2015
Severe infections represent the main cause of neonatal mortality accounting for more than one million neonatal deaths worldwide every year. Antibiotics are the most commonly prescribed medications in neonatal intensive care units (NICUs) and in industrialized countries about 1% of neonates are exposed to antibiotic therapy. Sepsis has often nonspecific signs and symptoms and empiric antimicrobial therapy is promptly initiated in high risk of sepsis or symptomatic infants. However continued use of empiric broad-spectrum antibiotic treatment in the setting of negative cultures especially in preterm infants may not be harmless. The benefits of antibiotic therapy when indicated are clearly enor…
Intracerebral Abscess Caused by Actinomyces israelii
2020
We describe a case of 49-years old female with a medical history of penicillin allergy, who suffered from brain infection caused by Actinomyces israelii. Therefore, the available therapy was metronidazole, ceftriaxone, and chloramphenicol. Due to a deterioration of the general and neurological condition of the patient, it was decided to perform a scratch skin test on penicillin, which was negative. After that, penicillin was administrated parenterally. The patient showed no hypersensitive reaction. Improvement was achieved. The patient underwent three subsequent surgeries due to primary and recurrent brain abscesses. There was a distinct improvement in her clinical status. Two months after …
Appropriateness in Dentistry: A Survey Discovers Improper Procedures in Oral Medicine and Surgery
2018
Objectives. The aim of this study was to assess appropriateness of diagnostic exams, treatments, and procedures among Italian dental practitioners.Materials and Methods. A questionnaire with multiple responses on topics of dentistry and oral medicine was administered to a sample of 198 Italian dental practitioners. Information on characteristics of the respondents was also collected. Descriptive statistics and multiple correspondence analysis (MCA) were applied. Data were analyzed using R software (version 3.3.2).Results. The survey respondents included Doctors of Medicine (MD) (54/198 = 27%) with or without specialty in dentistry (33% versus 67%), Doctors of Dental Surgery (DDS) (144/198 =…
Antibiotic resistance among Shigella serogroups isolated in Tehran, Iran (2002-2004)
2009
Shigellosis, one of the most common bacterial diarrhoeal diseases, is endemic throughout the world. It is one of the major causes of morbidity in children with diarrhoea in Iran [1-4]. Antibiotic therapy is useful and effective for shigellosis. Treatment is critical for persons with severe disease, particularly children and immunosuppressed patients. Use of an appropriate antibiotic therapy can shorten the duration of symptoms, significantly reduce the risk of transmission, and also prevent potentially lethal complications [5-7]. However, high frequencies of resistance in