Search results for " apnea"

showing 10 items of 261 documents

Gelatinases and their tissue inhibitors in a group of subjects with obstructive sleep apnea syndrome.

2016

Obstructive sleep apnea syndrome (OSAS) is associated with an elevated risk of cardiovascular events and stroke. Matrix metalloproteinases (MMPs) are endopeptidases involved in extracellular matrix degradation and then in the development and progression of cardiovascular diseases. Our aim was to evaluate plasma levels of gelatinases (MMP-2 and MMP-9) and their tissue inhibitors (TIMP-1 and TIMP-2) in a group of subjects with OSAS. We enrolled 48 subjects (36 men and 12 women; mean age 49.7 ± 14.68 yrs) with OSAS diagnosed with a 1-night cardiorespiratory study and then we subdivided these subjects into two subgroups according to the apnea/hypopnea index (AHI): Low (L = 21 subjects with AHI …

Malemedicine.medical_specialtyGelatinasesSettore MED/09 - Medicina InternaPhysiologyMMP-2; MMP-9; obstructive sleep apnea; TIMP-1; TIMP-2; Disease Progression; Female; Gelatinases; Humans; Male; Middle Aged; Sleep Apnea Obstructive; Tissue Inhibitor of Metalloproteinase-1; Physiology; Hematology; Cardiology and Cardiovascular Medicine; Physiology (medical)030204 cardiovascular system & hematologyMatrix metalloproteinaseGastroenterologyTIMP-203 medical and health sciencesTIMP-10302 clinical medicinePhysiology (medical)Internal medicinemedicineHumansStrokeobstructive sleep apneaOxygen saturation (medicine)Sleep Apnea ObstructiveTissue Inhibitor of Metalloproteinase-1MMP-2business.industryApneaCardiorespiratory fitnessHematologyMiddle Agedmedicine.diseasenervous system diseasesrespiratory tract diseasesObstructive sleep apneaEndocrinology030228 respiratory systemGelatinaseGelatinasesDisease ProgressionFemalemedicine.symptomMMP-9Settore MED/36 - Diagnostica Per Immagini E RadioterapiaCardiology and Cardiovascular MedicinebusinessHypopneaHumanClinical hemorheology and microcirculation
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Erythrocyte deformability, plasma lipid peroxidation and plasma protein oxidation in a group of OSAS subjects

2016

Considering that obstructive sleep apnea syndrome (OSAS) is usually associated with endothelial dysfunction, atherosclerosis and cardiovascular disorders, our aim was to examine the erythrocyte deformability and the oxidative status in a group of OSAS subjects. We consecutively enrolled 48 subjects with OSAS defined after a 1-night cardiorespiratory sleep study, subsequently subdivided according to the apnea/hypopnea index (AHI) value in two subgroups: Low (L = 21 subjects with AHI30) and High (H = 27 subjects with AHI30). We evaluated the erythrocyte deformability, expressed as elongation index (EI) and the parameters of the oxidative status, such as lipid peroxidation (expressed as thioba…

Malemedicine.medical_specialtyPhysiologyLipid peroxidation030204 cardiovascular system & hematologymedicine.disease_causeProtein oxidationBioinformaticsLipid peroxidation03 medical and health scienceschemistry.chemical_compound0302 clinical medicineBlood Proteinstomatognathic systemErythrocyte DeformabilityPhysiology (medical)Internal medicineErythrocyte deformability; Lipid peroxidation; OSAS; Protein oxidation; Blood Proteins; Erythrocyte Deformability; Female; Humans; Lipid Peroxidation; Male; Middle Aged; Oxidation-Reduction; Oxidative Stress; Sleep Apnea Obstructive; Physiology; Hematology; Cardiology and Cardiovascular Medicine; Physiology (medical)medicineTBARSHumansErythrocyte deformabilitySleep Apnea Obstructivebusiness.industryErythrocyte fragilityOSASOxidative StreBlood ProteinsHematologyMiddle Agedmedicine.diseaseBlood proteinsnervous system diseasesrespiratory tract diseasesOxidative StressEndocrinology030228 respiratory systemchemistryFemaleCardiology and Cardiovascular MedicinebusinessProtein oxidationOxidation-ReductionHypopneaOxidative stressHumanClinical Hemorheology and Microcirculation
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Lipid peroxidation and nitric oxide metabolites in a group of subjects with obstructive sleep apnea syndrome.

2015

It is known that in OSAS the plasma lipid peroxidation has an opposite behavior in comparison with nitric oxide metabolites. In the re-examination of our survey of OSAS subjects we calculated the ratio between thiobarbituric acid reactive substances (TBARS) and nitric oxide metabolites (NOx) in relation to OSAS severity. The study has regarded 48 OSAS subjects subdivided in two subgroups according to the apnea/hypopnea index - AHI- (Low = 21 subjects with AHI30 and High = 27 subjects with AHI30). From the obtained data it is evident that the TBARS/NOx ratio is significantly higher in the H subgroup compared to L subgroup as well as this ratio is reduced in L subgroup in comparison with the …

Malemedicine.medical_specialtyPhysiologyThiobarbituric acidobstructive sleep apnea syndrome030204 cardiovascular system & hematologyNitric OxideNitric oxideLipid peroxidation03 medical and health scienceschemistry.chemical_compound0302 clinical medicinestomatognathic systemnitric oxide metabolitePhysiology (medical)Internal medicineTBARSLipid peroxidation; nitric oxide metabolites; obstructive sleep apnea syndrome; Female; Humans; Lipid Peroxidation; Male; Middle Aged; Nitric Oxide; Sleep Apnea Obstructive; Physiology; Hematology; Cardiology and Cardiovascular Medicine; Physiology (medical)MedicineHumansNOxSleep Apnea Obstructivebusiness.industryApneaHematologyMiddle Agedmedicine.diseasenervous system diseasesrespiratory tract diseasesObstructive sleep apneaEndocrinology030228 respiratory systemchemistryFemaleLipid Peroxidationmedicine.symptomCardiology and Cardiovascular MedicinebusinessHypopneaHumanClinical hemorheology and microcirculation
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Metabolic Syndrome and Vitamin D Levels in Patients with Obstructive Sleep Apnea Syndrome

2018

Numerous studies have indicated that obstructive sleep apnea syndrome (OSAS), may contribute to the development of metabolic syndrome (MetS) and diabetes. Moreover, OSAS has been associated with lowered vitamin D (Vit D) levels, but reports are inconclusive. Aim of the study was to compare Vit D levels according to the presence of MetS and its components in OSAS patients.The presence of MetS was evaluated and serum 25-hydroxy vitamin D [25(OH)D] levels were measured in consecutive newly diagnosed, by polysomnography, subjects with OSAS.A total of 107 subjects (88 men) with OSAS were included in the study. Patients were divided into group A (OSAS with MetS group: 55 subjects) and group B (OS…

Malemedicine.medical_specialtyPolysomnographyEndocrinology Diabetes and MetabolismBlood Pressure030209 endocrinology & metabolismPolysomnographySeverity of Illness IndexGastroenterologyGroup BBody Mass Index03 medical and health sciences0302 clinical medicineDiabetes mellitusInternal medicineInternal MedicineVitamin D and neurologyHumansMedicineVitamin DAgedMetabolic SyndromeSleep Apnea ObstructiveAnthropometrymedicine.diagnostic_testbusiness.industryEpworth Sleepiness ScaleVitaminsMiddle AgedVitamin D Deficiencymedicine.diseasenervous system diseasesrespiratory tract diseasesObstructive sleep apneaFemaleMetabolic syndromebusinessBody mass index030217 neurology & neurosurgeryMetabolic Syndrome and Related Disorders
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A survey around the Italian pediatric units on current clinical practice for Sleep Disordered Breathing (SDB)

2019

Background During recent years, interest on Sleep Disordered Breathing (SDB) in pediatric age has increased, due to the impact on quality of life, psycho-physical attitude and other serious morbidities if undiagnosed and untreated. Methods Italian Pediatric Respiratory Diseases Society (SIMRI) SDB-Working Group carried out an exploratory survey in Italy, from January to December 2016, to assess the diagnostic and therapeutic pathways, perception and relevance of SDB in Italian Hospitals. Results A questionnaire was sent to 180 Pediatric Units (PUs) distributed throughout the Italy; 102 Pediatric Units (PUs; 56.6%) answered and among them 57% dealt with SDB, and 94% recognized SDB as a major…

Malemedicine.medical_specialtyPractice PatternsPolysomnographyChildren; Italy; Pediatric units; Sleep disordered breathing; Survey; Child; Female; Humans; Italy; Male; Practice Patterns Physicians'; Sleep Apnea Syndromes; Surveys and QuestionnairesChildren; Italy; Pediatric units; Sleep disordered breathing; Survey03 medical and health sciencesExploratory surveySleep Apnea Syndromes0302 clinical medicineQuality of lifeSurveys and Questionnaires030225 pediatricsmental disordersmedicineHumanscardiovascular diseases030212 general & internal medicinePractice Patterns Physicians'ChildPediatric unitsSurveyChildrenPhysicians'medicine.diagnostic_testSleep disordered breathingPediatric respiratory diseasesbusiness.industryResearchlcsh:RJ1-570lcsh:PediatricsPediatric agenervous system diseasesrespiratory tract diseasesNorthern italyClinical PracticeItalyEmergency medicineSleep disordered breathingFemalebusinessItalian Journal of Pediatrics
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Efficacy of mandibular advancement device in the treatment of obstructive sleep apnea syndrome: A randomized controlled crossover clinical trial

2015

Background Evaluation of the efficacy and safety of a mandibular advancement device (MAD) (KlearwayTM) in the treatment of mild-to-moderate obstructive sleep apnea and chronic roncopathy. Material and Methods A randomized, placebo-controlled, double blinded, and crossover clinical trial was conducted. Placebo device (PD) defined as a splint in the centric occlusion that did not induce a mandibular advancement served as a control. The mandible was advanced to the maximum tolerable distance or to a minimum of 65% of the maximum protrusion. After each sequence of treatment, patients were assessed by questionnaires, conventional polysomnography, and objective measurement of snoring at the patie…

Malemedicine.medical_specialtyanimal structuresOdontologíaPolysomnographyPlaceboSeverity of Illness Indexlaw.inventionRandomized controlled trialstomatognathic systemDouble-Blind MethodlawSeverity of illnessmedicineHumansGeneral DentistrySleep Apnea ObstructiveCross-Over Studiesmedicine.diagnostic_testbusiness.industryResearchSleep apneaMiddle Agedmedicine.disease:CIENCIAS MÉDICAS [UNESCO]Medically compromised patients in DentistryCrossover studyCiencias de la saludSurgeryrespiratory tract diseasesClinical trialObstructive sleep apneaTreatment OutcomeOtorhinolaryngologyAnesthesiaUNESCO::CIENCIAS MÉDICASSurgeryFemalebusinessMandibular AdvancementMedicina Oral, Patología Oral y Cirugía Bucal
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Obstructive sleep apnoea independently predicts lipid levels: Data from the European Sleep Apnea Database

2018

Background and objective: Obstructive sleep apnoea (OSA) and dyslipidaemia are independent risk factors for cardiovascular disease. This study investigates the association between OSA and plasma lipid concentrations in patients enrolled in the European Sleep Apnea Database (ESADA) cohort. Methods: The cross-sectional analysis included 8592 patients without physician-diagnosed hyperlipidaemia or reported intake of a lipid-lowering drug (age 50.1 ± 12.7 years, 69.1% male, BMI: 30.8 ± 6.6 kg/m2, mean apnoea–hypopnoea index (AHI): 25.7 ± 25.9 events/h). The independent relationship between measures of OSA (AHI, oxygen desaturation index (ODI), mean and lowest oxygen saturation) and lipid profil…

MaleobesityDatabases Factualcholesterol dyslipidemia hypoxia obesity sleep apnoeaGastroenterologyCohort Studieschemistry.chemical_compound0302 clinical medicineRisk FactorsHypolipidemic AgentsOxygen saturation (medicine)Sleep Apnea Obstructivemedicine.diagnostic_testSleep apneaMiddle AgedEuropeQuartileCardiovascular DiseasesCohortFemalelipids (amino acids peptides and proteins)AdultPulmonary and Respiratory Medicinemedicine.medical_specialtySettore MED/10 - Malattie Dell'Apparato Respiratorio03 medical and health sciencesInternal medicinemedicineHumansTriglyceridesDyslipidemiashypoxiaCholesterolbusiness.industryCholesterol HDLdyslipidemiacholesterolCholesterol LDLta3121medicine.diseaseObesitynervous system diseasesrespiratory tract diseasesCross-Sectional Studies030228 respiratory systemchemistryLipid profilebusinesssleep apnoea030217 neurology & neurosurgeryDyslipidemiaRespirology
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Cancer prevalence is increased in females with sleep apnoea: data from the ESADA study

2019

[No abstract available]

MaleobesityLetterDatabases FactualDownload[SDV]Life Sciences [q-bio]cigarette smokingPolysomnographycancer riskdisease burdenapnea hypopnea indexsleep disordered breathingstudy design0302 clinical medicinepolysomnographyRisk FactorsNothingcancer diagnosisNeoplasmsmiddle agedgenderPrevalence030212 general & internal medicineSleep studyobstructive sleep apneaSleep Apnea Obstructiveeducation.field_of_studyanthropometryquantitative analysismedicine.diagnostic_testadultrisk assessmentclinical trialcohort analysisprostate cancerpulse oximetry[SDV] Life Sciences [q-bio]Europenot availablecomorbidityagedfemalewaist hip ratiocolon cancerpriority journalrisk factorfactual databasedisease severitycerebrovascular accidentPulmonary and Respiratory Medicinemedicine.medical_specialtyalcohol consumptionintermittent hypoxiaPopulationMEDLINElymphomaSettore MED/10 - Malattie Dell'Apparato Respiratoriomalignant neoplasmcancer growth03 medical and health sciencesmelanomamedicinecancercross-sectional studyHumanscontrolled studyhumaneducationCancer prevalencehypoxiabusiness.industrystatistical modelConflict of interestpredictionmajor clinical studybody massoxygen saturationlung cancermulticenter studyCross-Sectional StudiesLogistic Modelsage030228 respiratory systemdisease severity assessmentFamily medicineoxygen desaturation indexhead and neck cancerHuman medicinebusinessneoplasmEuropean Respiratory Journal
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Effects of mandibular setback surgery on upper airway dimensions and their influence on obstructive sleep apnoea - a systematic review.

2015

Abstract Background Mandibular setback used to be the traditional treatment of choice for correcting mandibular prognathism. Nowadays, bimaxillary surgery is preferred. Several authors have asserted that mandibular setback causes a relative narrowing of the upper airway (UA) that could trigger obstructive sleep apnoea (OSA); however, its potential role in OSA development is still much debated. Another controversial subject is whether changes in airway space caused by the procedure are permanent. Objectives To ascertain the consequences for UA size and shape of mandibular setback surgery in comparison with bimaxillary surgery (maxillary advancement with Le Fort I and mandibular setback), and…

Mandibular setback surgerymedicine.medical_treatmentOrthognathic surgeryMEDLINEMandibular OsteotomyDentistryOropharynxstomatognathic systemNasopharynxmedicineMaxillaHumansOsteotomy Le FortOximetryOrthodonticsSleep Apnea Obstructivebusiness.industryClinical trialHypopharynxSystematic reviewMandibular prognathismOtorhinolaryngologyCohortPharynxSurgeryOral SurgerybusinessAirwayJournal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
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Perioperative Adverse Events in Obstructive Sleep Apnea and Use of Noninvasive Mechanical Ventilation: Key Topics and Clinical Implications

2016

Obstructive sleep apnea (OSA) is a common public health care problem and, yet, the perioperative management of OSA remains inadequate. Patients affected by this condition are prone to early postoperative complications, in part due to the negative effects of sedative, analgesic, and anesthetic agents on pharyngeal tone and arousal responses to hypoxia, hypercapnia, and obstruction. The use of opioids may also contribute to late adverse events, mainly by suppressing the rapid eye movement phase of sleep. As a result, preoperative screening of patients at high risk of OSA, as well as the implementation of a perioperative strategy to reduce the risk of complications, should lead to early periop…

Mechanical ventilationmedicine.medical_specialtymedicine.drug_classbusiness.industrymedicine.medical_treatmentPerioperativeHypoxia (medical)medicine.diseaserespiratory tract diseasesObstructive sleep apneaSedativeObstructive sleep apnea Perioperative complications Noninvasive ventilation Noninvasive positive pressure ventilation Continuous positive airway pressuremedicineContinuous positive airway pressuremedicine.symptomIntensive care medicineAdverse effectbusinessHypercapnia
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