Search results for " array"
showing 10 items of 895 documents
Using coded excitation to maintain signal to noise for FMC+TFM on attenuating materials
2019
Ultrasonic Non-Destructive Evaluation using Full Matrix Capture (FMC) and Total Focusing Method (TFM) is used for high resolution imaging as every pixel is in optimal focus. FMC excites one element in turn, so operates with lower transmitted energy compared to phased array beamforming. The energy at a reflector is further reduced by the broad directivity pattern of the single element. The large number of Tx/Rx A-scans that contribute to each pixel recover the Signal-to-Noise Ratio (SNR) in the final TFM image. Maintaining this in the presence of attenuating materials is a challenge because relevant information in each A-scan signal is buried in the thermal noise, and the TFM process assumes…
Analysis of a microwave time delay line based on a perturbed uniform fiber Bragg grating operating at constant wavelength
2000
This paper presents the modeling of a new microwave time delay line based on a uniform fiber Bragg grating (FBG) with a section which period has been perturbed. The time delay can be modified by changing the position of the perturbation along the grating. Theoretical results are presented for a 5-cm long uniform grating and optical signal is modulated up to 18 GHz. Experimental setup used magnetic fields to change the period locally along the grating and a 330 ps maximum time delay is shown. Comparison between calculations and measurements show a perfect agreement. Such a delay line offers many advantages for beamforming applications in phased array antennas where the operation at a fixed w…
Real-time Sound Source Localization on an Embedded GPU Using a Spherical Microphone Array
2015
Abstract Spherical microphone arrays are becoming increasingly important in acoustic signal processing systems for their applications in sound field analysis, beamforming, spatial audio, etc. The positioning of target and interfering sound sources is a crucial step in many of the above applications. Therefore, 3D sound source localization is a highly relevant topic in the acoustic signal processing field. However, spherical microphone arrays are usually composed of many microphones and running signal processing localization methods in real time is an important issue. Some works have already shown the potential of Graphic Processing Units (GPUs) for developing high-end real-time signal proce…
Multi-aperture beamforming for automated large structure inspection using ultrasonic phased arrays
2019
Increasing the inspection quality and speed is essential in manufacturing applications, especially for large structures (e.g. modern aircrafts). Traditional ultrasonic manual scanning can be comprehensive, but lacks repeatability and is time-consuming. Several robotic non-destructive testing systems have been developed in recent years. Although high inspection rates have been achieved by the use of robotic arms, there is the need to furtherly increase the inspection speeds, to cope with the current industrial demands. For systems delivering robotic ultrasonic inspection through phased array probes, the current bottleneck is given by the time required to electrically fire all elements of the…
Hybrid, multiplexed, functional DNA nanotechnology for bioanalysis
2015
We herein aim to report on the fabrication of DNA nano-heterostructures usable as a robust multi-functional analytical system to obtain multiple and complex data in parallel format from a single sample with unprecedented analytical performances. The ability of chemical information contained in the sequences of programmed DNA structures to organize matter made DNA become a unique material in “the nanoworld”. Such carefully designed DNA nanostructures can then be functionalized/templated with different biomolecules/nanomaterials as different as nanoparticles, nanowires, organic molecules, peptides, and proteins with controlled spacing on the nanometer scale (<10 nm). In this way, it is possib…
Sparse Manifold Clustering and Embedding to discriminate gene expression profiles of glioblastoma and meningioma tumors.
2013
Sparse Manifold Clustering and Embedding (SMCE) algorithm has been recently proposed for simultaneous clustering and dimensionality reduction of data on nonlinear manifolds using sparse representation techniques. In this work, SMCE algorithm is applied to the differential discrimination of Glioblastoma and Meningioma Tumors by means of their Gene Expression Profiles. Our purpose was to evaluate the robustness of this nonlinear manifold to classify gene expression profiles, characterized by the high-dimensionality of their representations and the low discrimination power of most of the genes. For this objective, we used SMCE to reduce the dimensionality of a preprocessed dataset of 35 single…
Array CGH defined interstitial deletion on chromosome 14: a new case
2009
Interstitial deletions of the long arm of chromosome 14 are relatively rare. We report a 8.5-year-old girl with dysmorphic facial features and mental retardation associated with a de novo interstitial deletion of chromosome 14. The comparison between our patient and all published patients is reviewed. The genetic investigations have allowed us to define the critical chromosomal region and to start an accurate follow-up.
Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas
2007
AbstractIntegrative genomic and gene-expression analyses have identified amplified oncogenes in B-cell non-Hodgkin lymphoma (B-NHL), but the capability of such technologies to localize tumor suppressor genes within homozygous deletions remains unexplored. Array-based comparative genomic hybridization (CGH) and gene-expression microarray analysis of 48 cell lines derived from patients with different B-NHLs delineated 20 homozygous deletions at 7 chromosome areas, all of which contained tumor suppressor gene targets. Further investigation revealed that only a fraction of primary biopsies presented inactivation of these genes by point mutation or intragenic deletion, but instead some of them w…
Functional Genomics of 5-to 8-Cell Stage Human Embryos by Blastomere Single-Cell cDNA Analysis
2010
Blastomere fate and embryonic genome activation (EGA) during human embryonic development are unsolved areas of high scientific and clinical interest. Forty-nine blastomeres from 5- to 8-cell human embryos have been investigated following an efficient single-cell cDNA amplification protocol to provide a template for high-density microarray analysis. The previously described markers, characteristic of Inner Cell Mass (ICM) (n = 120), stemness (n = 190) and Trophectoderm (TE) (n = 45), were analyzed, and a housekeeping pattern of 46 genes was established. All the human blastomeres from the 5- to 8-cell stage embryo displayed a common gene expression pattern corresponding to ICM markers (e.g., …
Human stem cells from single blastomeres reveal pathways of embryonic or trophoblast fate specification.
2015
Mechanisms of initial cell fate decisions differ among species. To gain insights into lineage allocation in humans, we derived ten human embryonic stem cell lines (designated UCSFB1-10) from single blastomeres of four 8-cell embryos and one 12-cell embryo from a single couple. Compared with numerous conventional lines from blastocysts, they had unique gene expression and DNA methylation patterns that were, in part, indicative of trophoblast competence. At a transcriptional level, UCSFB lines from different embryos were often more closely related than those from the same embryo. As predicted by the transcriptomic data, immunolocalization of EOMES, T brachyury, GDF15 and active β-catenin reve…