Search results for " array"

Clostridium difficile toxin A induces expression of the stress-induced early gene product RhoB.

2004

Clostridium difficile toxin A monoglucosylates the Rho family GTPases Rho, Rac, and Cdc42. Glucosylation leads to the functional inactivation of Rho GTPases and causes disruption of the actin cytoskeleton. A cDNA microarray revealed the immediate early gene rhoB as the gene that was predominantly up-regulated in colonic CaCo-2 cells after treatment with toxin A. This toxin A effect was also detectable in epithelial cells such as HT29 and Madin-Darby canine kidney cells, as well as NIH 3T3 fibroblasts. The expression of RhoB was time-dependent and correlated with the morphological changes of cells. The up-regulation of RhoB was approximately 15-fold and was based on the de novo synthesis of …

Implementation of Universal Digital Architecture using 3D-NoC for Mobile Terminal

2014

International Conference on Control, Decision and Information Technologies (CoDIT), Ecole Natl Ingenieurs Metz, Metz, FRANCE, NOV 03-05, 2014; International audience; The need to integrate multiple wireless communication protocols into a single low-cost flexible hardware platform is prompted by the increasing number of emerging communication protocols and applications in modern embedded systems. So the current challenge is to design of new digital architectures, in addition to its ability to take over of many functions. In this paper we have identified similarities between the despreader units in Rake receiver and the processor element in FFT-SDF (Fast Fourier Transform-Single path Delay Fe…

Chaotic Properties of Dilute Two and Three Dimensional Random Lorentz Gases II: Open Systems

2000

We calculate the spectrum of Lyapunov exponents for a point particle moving in a random array of fixed hard disk or hard sphere scatterers, i.e. the disordered Lorentz gas, in a generic nonequilibrium situation. In a large system which is finite in at least some directions, and with absorbing boundary conditions, the moving particle escapes the system with probability one. However, there is a set of zero Lebesgue measure of initial phase points for the moving particle, such that escape never occurs. Typically, this set of points forms a fractal repeller, and the Lyapunov spectrum is calculated here for trajectories on this repeller. For this calculation, we need the solution of the recently…

Generation of Hardware/Software systems based on CAL dataflow description

2011

International audience; This paper presents a new development of rapid prototyping tools for system design based on data-flow specifications. In this context, the efficiency of tools for the automatic translation from the data-flow programs to C and/or HDL are assessed by means of two design cases. The paper also introduces the new concept of the automatic synthesis of interfaces. Such generic interfaces are implemented by using an embedded microprocessor, which can support a large variety of interfaces already available as native IP libraries in the case of FPGA. The two design cases described here have been developed, tested and validated on different implementation platforms. The results…

Rapid prototyping platform for stream-oriented reconfigurable computing applications

2010

In this paper we present a methodology and tool for rapid prototyping of real time image processing applications. We describe our design flow of multiprocessor system on chip (MPSoC) architectures based on hardware/software components. This methodology provides automated methods to specify, generate the hardware, software, and the architectural interfaces between them. Our methodology starts from system level specification of the application with parallel processes described in C-code. The processes communicate through an abstract channel called streams. We describe also the solution that we proposed to synthesize a custom bus architecture for the reconfigurable computing applications, whic…

Innovative systems based on optical nanoantennas for energy harvesting application

The purpose of this study is to outline the main guidelines for the design of arrays of optical rectennas aiming to harvest energy and for the optimization of the power transfer to an external load. In particular, the novelty of this study consists in introducing the concept of the integrated design between the array of optical rectennas and the harvesting circuit able to exploit the available energy. The design of the array represents the crucial point in order to optimize the power transfer between the antenna and the load and can influence the rectenna design. On the other hand, the maximum power transfer to the load has to be obtained under matching conditions between the array and the …

Transcription- and apoptosis-dependent long-range distribution of tight DNA-protein complexes in the chicken alpha-globin gene.

2008

The proteins tightly bound to DNA (TBP) are a group of proteins that remain attached to DNA with covalent or noncovalent bonds after its deproteinization, and have been hypothesized to be involved in regulation of gene expression. To investigate this question further, oligonucleotide DNA arrays were used to determine the distribution of tightly bound proteins along a 100-kb DNA fragment surrounding the chicken alpha-globin gene domain in DNA from chicken erythrocytes, liver, and AEV-transformed HD3 (erythroblast) cells in different physiological conditions. DNA was fractionated into TBP-free (F) and TBP-enriched (R) fractions by separation on nitrocellulose, and these fractions were used as…

Genomic response programs of Candida albicans following protoplasting and regeneration

2005

Transcription profiling of Candida albicans cells responding to the elimination of the wall (protoplasts) and posterior regeneration was explored. DNA microarrays were used to measure changes in the expression of 6039 genes, and the upregulated genes during regeneration at 28 degrees C were assigned to fourteen categories. A total of 407 genes were upregulated during the process, of which 144 reached a maximum after 1 h. MKC1, a gene encoding a member of the regulatory pathway involved in cell wall integrity was overexpressed. Time-dependent expression divided the genes into 40 clusters. Clusters 1-19 were highly expressed initially (time 0) and downregulated following incubation, whereas t…

Reliability and Retention Study of Nanocrystal Cell Array

2002

We have studied nanocrystal memory arrays with 2.56 × 105 cells (256kb) in which Si nanocrystals have been obtained by CVD deposition on a 4nm tunnel oxide. The cells in the array are programmed and erased by electron tunneling through the SiO2 dielectric. We find that the threshold voltage distribution has little spread. In addition the arrays are also very robust with respect to drain stress and show good retention.

Metabolomic changes in the rat retina after optic nerve crush.

2013

Purpose To identify metabolic pathways and metabolites affected by optic nerve crush that can act as predictors of the disease or therapeutic targets. Methods The left optic nerve of adult rats was intraorbitally crushed and retinas were dissected 24 hours or 14 days after the lesion (n = 10 per group). Metabolic profiling analysis was carried out by Metabolon, Inc. A total of 195 metabolites were unambiguously detected. Data were normalized and the regulated metabolites were identified after comparing the different conditions. Metabolite concentration changes were analyzed using single and multivariate statistical analysis to detect discriminatory metabolites. Functional clustering and met…