Search results for " assembly"

On the thermo-mechanical behaviour of the IFMIF target assembly under steady state and transient operative scenarios

Analysis of the thermo-mechanical behaviour of IFMIF target assembly integrated with its support framework

2014

On the computational assessment of the IFMIF-EVEDA Target Assembly thermal behaviour

2011

ISWI Regulates Higher-Order Chromatin Structure and Histone H1 Assembly In Vivo

2007

Imitation SWI (ISWI) and other ATP-dependent chromatin-remodeling factors play key roles in transcription and other processes by altering the structure and positioning of nucleosomes. Recent studies have also implicated ISWI in the regulation of higher-order chromatin structure, but its role in this process remains poorly understood. To clarify the role of ISWI in vivo, we examined defects in chromosome structure and gene expression resulting from the loss of Iswi function in Drosophila. Consistent with a broad role in transcriptional regulation, the expression of a large number of genes is altered in Iswi mutant larvae. The expression of a dominant-negative form of ISWI leads to dramatic a…

Analysis and design of sequencing rules for car sequencing

2009

Abstract This paper presents novel approaches for generating sequencing rules for the car sequencing (CS) problem in cases of two and multiple processing times per station. The CS problem decides on the succession of different car models launched down a mixed-model assembly line. It aims to avoid work overloads at the stations of the line by applying so-called sequencing rules, which restrict the maximum occurrence of labor-intensive options in a subsequence of a certain length. Thus to successfully avoid work overloads, suitable sequencing rules are essential. The paper shows that the only existing rule generation approach leads to sequencing rules which misclassify feasible sequences. We …

Il perimetro variabile dell’insindacabilità dei Consiglieri regionali: la vis politica delle decisioni “strategiche” per l’economia regionale. Nota a…

2022

La sentenza n. 90 del 2022 della Corte costituzionale risolve un conflitto di attribuzioni fra Stato e Regione Valle d’Aosta originato dalla sentenza della sezione giurisdizionale III centrale della Corte dei conti (la nr. 350 del 2021) di condanna per responsabilità da danno erariale nei confronti di diversi Consiglieri della Regione per aver deliberato un atto amministrativo concernente un’operazione di rifinanziamento del Casinò di Saint-Vincent. A differenza dei criteri precedentemente seguiti per definire l’ambito di applicazione dell’insindacabilità dei Consiglieri regionali nell’ipotesi di deliberazioni consiliari relative ad atti non legislativi (cfr. spec. Corte cost. nn. 69 e 70 d…

Processing of procollagen III by meprins: new players in extracellular matrix assembly?

2010

Meprins α and β, a subgroup of zinc metalloproteinases belonging to the astacin family, are known to cleave components of the extracellular matrix, either during physiological remodeling or in pathological situations. In this study we present a new role for meprins in matrix assembly, namely the proteolytic processing of procollagens. Both meprins α and β release the N- and C-propeptides from procollagen III, with such processing events being critical steps in collagen fibril formation. In addition, both meprins cleave procollagen III at exactly the same site as the procollagen C-proteinases, including bone morphogenetic protein-1 (BMP-1) and other members of the tolloid proteinase family. …

Synthesis and cation-exchange properties of a bis-zwitterionic lamellar hybrid material

2008

The synthesis of a bis-zwitterionic lamellar hybrid material containing ammonium carboxylate groups is described. Cation-exchange properties of this material towards transition metal and lanthanide ions were studied as well as the regeneration and reuse of the material.

Expression inactivation of SMARCA4 by microRNAs in lung tumors

2014

SMARCA4 is the catalytic subunit of the SWI/SNF chromatin-remodeling complex, which alters the interactions between DNA and histones and modifies the availability of the DNA for transcription. The latest deep sequencing of tumor genomes has reinforced the important and ubiquitous tumor suppressor role of the SWI/SNF complex in cancer. However, although SWI/SNF complex plays a key role in gene expression, the regulation of this complex itself is poorly understood. Significantly, an understanding of the regulation of SMARCA4 expression has gained in importance due to recent proposals incorporating it in therapeutic strategies that use synthetic lethal interactions between SMARCA4-MAX and SMAR…

Supramolecular assembly of functional peptide-polymer conjugates.

2019

The following review gives an overview about synthetic peptide-polymer conjugates as macromolecular building blocks and their self-assembly into a variety of supramolecular architectures, from supramolecular polymer chains, to anisotropic 1D arrays, 2D layers, and more complex 3D networks. A selection of recent literature examples using linear, coiled-coil and cyclic peptide motifs is provided. The reversible nature of the unimer-to-supramolecular polymer transition provides unique opportunities to investigate mechanistic aspects of the supramolecular assembly, with respect to the thermodynamic or kinetic parameters and furthermore provides exciting opportunities for non-equilibrium assembl…