Search results for " attachment"
showing 10 items of 207 documents
Parenting style and peer attachment as predictors of emotional instability in children
2017
We analyzed the roles of parenting style and peer attachment in predicting emotional instability in late childhood and early adolescence. Effects were analyzed separately by gender. Children's personal variables analyzed were empathy, anger, and the mechanisms used to cope with anger (externalization and self-control). Participants were 316 girls and 294 boys (N = 610) aged from 9 to 12 years who were students at schools in Valencia, Spain. Main gender differences for each variable were examined using one-way ANOVAs. Results of 2 multiple linear regression analyses (1 for boys and 1 for girls) explained 50.9% and 35.5%, respectively, of variance in the students' emotional instability. Consi…
Empirically-derived subgroups of Facebook users and their association with personality characteristics: a Latent Class Analysis
2018
Abstract In recent years, considerable research effort has been directed at the identification of relationships between psychological variables and Facebook usage indicators. However, the identification of homogeneous subgroups of individuals based on similar Facebook usage characteristics still presents a challenge. This study aims: (1) to empirically determine homogeneous groups of Facebook users based on variables regarding their personal experience on Facebook, by using a Latent Class Analysis; and (2) to examine the association between an individual's personality and interpersonal characteristics and the empirically-derived profiles of Facebook usage. Eight hundred and eleven Facebook …
Towards realistic artificial benchmark for community detection algorithms evaluation
2013
Many algorithms have been proposed for revealing the community structure in complex networks. Tests under a wide range of realistic conditions must be performed in order to select the most appropriate for a particular application. Artificially generated networks are often used for this purpose. The most realistic generative method to date has been proposed by Lancichinetti, Fortunato and Radicchi (LFR). However, it does not produce networks with some typical features of real-world networks. To overcome this drawback, we investigate two alternative modifications of this algorithm. Experimental results show that in both cases, centralisation and degree correlation values of generated networks…
The shared image guiding the treatment process. A precondition for integration of the treatment of schizophrenia.
1994
The aim of the study reported here was to develop psychotherapeutic in-patient treatment for acute schizophrenia, following the principles of a need-adapted approach. To improve the integration of experiences which hospital staff have with acutely psychotic patients and their families, systematic supervision sessions were organised. In these sessions, it was possible to achieve shared psychological images through which the whole staff could integrate patients' behaviour and symptoms, both symbolic and non-symbolic. Such an image was called ‘the shared image guiding the treatment process’ (SIGTP). The process of achieving the SIGTP was interpreted through Peircean semiotics, especially the c…
A pilot study to evaluate the effectiveness of adjunctive use of two antimicrobial topical gels in chronic gingivitis
2021
Background Gingivitis is one of the most prevalent oral disease in humans. The most important etiological factor of gingivitis is dental plaque. Plaque control procedures comprises of several mechanical and chemical methods. Many studies have advocated that chemical plaque control methods can be used successfully as an adjunct to mechanical plaque control procedures. Thus, the aim of this pilot study is to evaluate the effectiveness of two topical antimicrobial gels as an adjunct to mechanical plaque control over a period of 2 weeks in treatment of chronic gingivitis patients. Material and methods This is a single blind, two arm parallel design pilot clinical study including 60 systemically…
Ascl1 Coordinately Regulates Gene Expression and the Chromatin Landscape during Neurogenesis
2015
Summary The proneural transcription factor Ascl1 coordinates gene expression in both proliferating and differentiating progenitors along the neuronal lineage. Here, we used a cellular model of neurogenesis to investigate how Ascl1 interacts with the chromatin landscape to regulate gene expression when promoting neuronal differentiation. We find that Ascl1 binding occurs mostly at distal enhancers and is associated with activation of gene transcription. Surprisingly, the accessibility of Ascl1 to its binding sites in neural stem/progenitor cells remains largely unchanged throughout their differentiation, as Ascl1 targets regions of both readily accessible and closed chromatin in proliferatin…
Squaric Acid Mediated Synthesis and Biological Activity of a Library of Linear and Hyperbranched Poly(Glycerol)-Protein Conjugates
2012
Polymer-protein conjugates generated from side chain functional synthetic polymers are attractive because they can be easily further modified with, for example, labeling groups or targeting ligands. The residue specific modification of proteins with side chain functional synthetic polymers using the traditional coupling strategies may be compromised due to the nonorthogonality of the side-chain and chain-end functional groups of the synthetic polymer, which may lead to side reactions. This study explores the feasibility of the squaric acid diethyl ester mediated coupling as an amine selective, hydroxyl tolerant, and hydrolysis insensitive route for the preparation of side-chain functional, …
Concise and modular synthesis of regioisomeric haptens for the production of high-affinity and stereoselective antibodies to the strobilurin azoxystr…
2011
The immune response to regioisomeric haptens of azoxystrobin with varied derivatization sites was studied. Based on the Sonogashira and Suzuki-Miyaura couplings and following a straightforward modular design, we have synthesized four haptens with the same linker anchored through C-C bonds and located at different sites of the molecule. The most stereoselective antibodies were produced from immunogens with the spacer arm at a distal position from the β-methoxyacrylate moiety characteristic of strobilurins. Moreover, we observed that assay cross-reactivity was reliant on the functionalization site of the competitor derivative. Finally, the antibody binding site was explored using synthetic ch…
Nothing matters: the significance of the unidentifiable, the superficial and nonsense
2019
ABSTRACT Purpose: The aim of this study is to explore the ways in which “small things” may be of importance for people with mental health difficulties. Method: Empirical material from three different studies was reanalysed through a phenomenological, dialogical, approach. Results: We discovered some paradoxical aspects of small things: i.e., they could be about “something” that was difficult or even impossible to identify. The unidentifiable could be about bodily, sensual experiences that are superficial (i.e., belonging to the surface). The interaction with others highlighted as significant could be about doing something fun, talking nonsense or kidding around, and hence not at all about m…
Polyethylenimine is a strong inhibitor of human papillomavirus and cytomegalovirus infection.
2012
ABSTRACT Polyethylenimines are cationic polymers with potential as delivery vectors in gene therapy and with proven antimicrobial activity. However, the antiviral activity of polyethylenimines has not been addressed in detail thus far. We have studied the inhibitory effects of a linear 25-kDa polyethylenimine on infections with human papillomaviruses and human cytomegaloviruses. Preincubation of cells with polyethylenimine blocked primary attachment of both viruses to cells, resulting in a significant reduction of infection. In addition, the dissemination of human cytomegalovirus in culture cells was efficiently reduced by recurrent administration of polyethylenimine. Polyethylenimine conce…